Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic syndrome in C57BL/6J mice fed with high-fat diet

Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling

(2018) Shuhao Su et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antitussive and expectorant properties of growing and fallen leaves of loquat ( Eriobotrya japonica )

(2018) Yue-xian Wu et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Antitussive and expectorant properties of growing and fallen leaves of loquat ( Eriobotrya japonica )

(2018) Yue-xian Wu et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

(2016) Carlos Huerta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

(2016) Kimberly O. Cameron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors

(2015) Ke Zheng et al.   ACS Medicinal Chemistry Letters

Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity

(2015) Joo-Man Park et al.   Scientific Reports

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

(2012) Stephen J. Mills et al.   ACS Chemical Biology

Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats

(2012) Gopalsamy Rajiv Gandhi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma

(2012) Seung-Hyung Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish

(2012) JAE-YONG KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)

(2012) James S. Scott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of Green Tea Polyphenol (−)-Epigallocatechin-3-gallate on Newly Developed High-Fat/Western-Style Diet-Induced Obesity and Metabolic Syndrome in Mice

(2011) Yu-Kuo Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biaryl substituted hydantoin compounds as TACE inhibitors

(2010) Wensheng Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

The 11- -Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

(2010) J. Rosenstock et al.   DIABETES CARE

Hexose-6-Phosphate Dehydrogenase Contributes to Skeletal Muscle Homeostasis Independent of 11β-Hydroxysteroid Dehydrogenase Type 1

(2010) Nina M. Semjonous et al.   ENDOCRINOLOGY

Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high-fat-fed mice

(2010) Chun-Ching Shih et al.   PHYTOTHERAPY RESEARCH

Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium Eriobotryae

(2009) H. Lü et al.   JOURNAL OF ETHNOPHARMACOLOGY

Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

(2009) Brenton Flatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of corosolic acid on gluconeogenesis in rat liver

(2008) Kotaro Yamada et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors

(2008) Sijiu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY