Metabolic Reprogramming in COVID-19

Multi-organ proteomic landscape of COVID-19 autopsies

(2021) Xiu Nie et al.   CELL

Diabetes, obesity, metabolism and SARS-CoV-2 infection: The end of the beginning

(2021) Daniel J. Drucker   Cell Metabolism

Host cell glutamine metabolism as a potential antiviral target

(2021) Sandro Massao Hirabara et al.   CLINICAL SCIENCE

The Atherogenic Index of Plasma as a Predictor of Mortality in Patients with COVID-19

(2021) Özge Turgay Yıldırım et al.   HEART & LUNG

SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage

(2021) Florian Reizine et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Could targeting immunometabolism be a way to control the burden of COVID-19 infection?

(2021) Engin Berber et al.   MICROBES AND INFECTION

The Fatty Acid Lipid Metabolism Nexus in COVID-19

(2021) Jerome E. Tanner et al.   Viruses-Basel

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells

(2021) Shiv Bharadwaj et al.   Frontiers in Molecular Biosciences

Beneficial Effect of Statins in COVID-19–Related Outcomes—Brief Report

(2021) Hae-Young Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cholesterol metabolism pathways – are the intermediates more important than the products?

(2021) Yuqin Wang et al.   FEBS Journal

Association between antecedent statin use and severe disease outcomes in COVID-19: A retrospective study with propensity score matching

(2021) Prateek Lohia et al.   Journal of Clinical Lipidology

Association of serum HDL cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection

(2021) James R. Hilser et al.   JOURNAL OF LIPID RESEARCH

Clinical efficacy of eucaloric ketogenic nutrition in the Covid-19 cytokine storm (CSS): a retrospective analysis of mortality and Intensive Care Unit admission

(2021) SG Sukkar et al.   NUTRITION

Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis

(2021) Roberta Nardacci et al.   Cell Death & Disease

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

(2021) Aakriti Gupta et al.   Nature Communications

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

(2021) Nan Xiao et al.   Nature Communications

Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis

(2021) Amir Vahedian-Azimi et al.   Archives of Medical Science

COVID-19: A methyl-group assault?

(2021) Andrew McCaddon et al.   MEDICAL HYPOTHESES

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

(2021) Yuchen Zhang et al.   Nature Communications

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

(2021) Peter J. Mullen et al.   Nature Communications

Low HDL and high triglycerides predict COVID-19 severity

(2021) Lluís Masana et al.   Scientific Reports

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

(2021) David W Sanders et al.   eLife

Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019

(2021) Furong Qi et al.   Frontiers in Immunology

Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19

(2021) Chieh-Chen Wu et al.   Journal of Clinical Medicine

Statin use and mortality in COVID-19 patients: Updated systematic review and meta-analysis

(2021) Anastasios Kollias et al.   ATHEROSCLEROSIS

Lipid metabolism changes in patients with severe COVID-19

(2021) Yi Li et al.   CLINICA CHIMICA ACTA

Metabolomic analyses reveals new stage-specific features of the COVID-19

(2021) Hongling Jia et al.   EUROPEAN RESPIRATORY JOURNAL

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19?

(2021) Rita Rubin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Severe COVID‐19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin

(2021) Rodolfo Soria‐Castro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered amino acid profile in patients with SARS-CoV-2 infection

(2021) Chris A. Rees et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

(2021) Travis Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

(2021) Caroline G. Williams et al.   Cell Reports

Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity

(2021) Daniel Tomé   Nutrition & Diabetes

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice

(2021) Seungjin Ryu et al.   eLife

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

(2021) Desirée Bartolini et al.   Redox Biology

Prior Statin Use and Risk of Mortality and Severe Disease From Coronavirus Disease 2019: A Systematic Review and Meta-analysis

(2021) Zachary A Yetmar et al.   Open Forum Infectious Diseases

Identification of Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected patients Through Single-Cell Transcriptome Sequencing

(2021) Yan Zhang et al.   Engineering

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

Hypolipidemia is associated with the severity of COVID-19

(2020) Xiuqi Wei et al.   Journal of Clinical Lipidology

Letter to the Editor: Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019

(2020) Junli Fan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

Statin therapy in COVID-19 infection

(2020) Vincenzo Castiglione et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Cholesterol metabolism: New functions and therapeutic approaches in cancer

(2020) Huanji Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

(2020) Xiao-Jing Zhang et al.   Cell Metabolism

Teaching Old Drugs New Tricks: Statins for COVID-19?

(2020) David C. Fajgenbaum et al.   Cell Metabolism

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

(2020) Jin-Wen Song et al.   Cell Metabolism

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 ( Covid ‐19)

(2020) Yue Zhou et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS

(2020) Alessandro Marcello et al.   Redox Biology

Statin therapy in COVID-19 infection: much more than a single pathway

(2020) Maurizio Bifulco et al.   European Heart Journal-Cardiovascular Pharmacotherapy

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

(2020) Tiffany Thomas et al.   JCI Insight

Identification of required host factors for SARS-CoV-2 infection in human cells

(2020) Zharko Daniloski et al.   CELL

25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

(2020) Shulong Zu et al.   CELL RESEARCH

COVID-19 update: The race to therapeutic development

(2020) Julianne D. Twomey et al.   DRUG RESISTANCE UPDATES

Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol

(2020) Shaobo Wang et al.   EMBO JOURNAL

COVID-19: discovery, diagnostics and drug development

(2020) Tarik Asselah et al.   JOURNAL OF HEPATOLOGY

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection

(2020) Torben Kimhofer et al.   JOURNAL OF PROTEOME RESEARCH

Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study

(2020) Guyi Wang et al.   Lipids in Health and Disease

Large-Scale Multi-omic Analysis of COVID-19 Severity

(2020) Katherine A. Overmyer et al.   Cell Systems

Statin Use Is Associated with Decreased Risk of Invasive Mechanical Ventilation in COVID-19 Patients: A Preliminary Study

(2020) Sophia L. Song et al.   Pathogens

Computational and Transcriptome Analyses Revealed Preferential Induction of Chemotaxis and Lipid Synthesis by SARS-CoV-2

(2020) Hibah Shaath et al.   Biology-Basel

Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19

(2020) Saima Ajaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Arginine depletion as a therapeutic approach for patients with COVID-19

(2020) Joseph M. Grimes et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

(2020) Elettra Barberis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Commentary: Statins, COVID-19, and coronary artery disease: killing two birds with one stone

(2020) Shiva Ganjali et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-density lipoprotein cholesterol as a factor affecting virus clearance in covid-19 patients

(2020) Xinmin Ding et al.   RESPIRATORY MEDICINE

Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study

(2020) Jawad Haider Butt et al.   BMJ Open

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

(2020) Suelen Silva Gomes Dias et al.   PLoS Pathogens

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

(2020) Rongjuan Pei et al.   Protein & Cell

Lipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19

(2020) Jia Teng Sun et al.   Frontiers in Cardiovascular Medicine

Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort study.

(2020) Luana Lionetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

(2019) María Maximina B. Moreno-Altamirano et al.   Frontiers in Cellular and Infection Microbiology

Viral hijacking of cellular metabolism

(2019) Shivani K. Thaker et al.   BMC BIOLOGY

Ketogenic diet in the treatment of cancer – Where do we stand?

(2019) Daniela D. Weber et al.   Molecular Metabolism

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

(2019) Emily L. Goldberg et al.   Science Immunology

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

(2017) Erica L. Sanchez et al.   JOURNAL OF VIROLOGY

Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements

(2017) Abdulla A-B. Badawy   NEUROPHARMACOLOGY

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Effect of inflammation on HDL structure and function

(2016) Kenneth R. Feingold et al.   CURRENT OPINION IN LIPIDOLOGY

Arginine Metabolism Revisited

(2016) Sidney M Morris   JOURNAL OF NUTRITION

Parenteral or Enteral Arginine Supplementation Safety and Efficacy

(2016) Martin D Rosenthal et al.   JOURNAL OF NUTRITION

When Is It Appropriate to Use Arginine in Critical Illness?

(2016) Jayshil J. Patel et al.   NUTRITION IN CLINICAL PRACTICE

Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: Relevance to cancer-related fatigue

(2015) Sangmi Kim et al.   CANCER

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

The Role of Dietary Cholesterol in Lipoprotein Metabolism and Related Metabolic Abnormalities: A Mini-review

(2015) Fatemeh Ramezani Kapourchali et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

(2015) Christopher M. Goodwin et al.   TRENDS IN MICROBIOLOGY

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Structure and function of biotin-dependent carboxylases

(2012) Liang Tong   CELLULAR AND MOLECULAR LIFE SCIENCES

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Is Glutamine a Conditionally Essential Amino Acid?

(2010) Janet M. Lacey et al.   NUTRITION REVIEWS

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE