Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol

Super-resolution fluorescence-assisted diffraction computational tomography reveals the three-dimensional landscape of the cellular organelle interactome

(2020) Dashan Dong et al.   Light-Science & Applications

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Considerations for Statin Therapy in Patients with COVID‐19

(2020) Simin Dashti‐Khavidaki et al.   PHARMACOTHERAPY

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

(2020) Jiumeng Sun et al.   TRENDS IN MOLECULAR MEDICINE

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

(2020) Michael E. Abrams et al.   Nature Microbiology

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Statin therapy in COVID-19 infection

(2020) Vincenzo Castiglione et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

(2020) Xiao-Jing Zhang et al.   Cell Metabolism

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

The Role of Host Cholesterol During Flavivirus Infection

(2018) Juan Fidel Osuna-Ramos et al.   Frontiers in Cellular and Infection Microbiology

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

The role of cholesterol in membrane fusion

(2016) Sung-Tae Yang et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The effect of fluvastatin on cardiac fibrosis and angiotensin-converting enzyme-2 expression in glucose-controlled diabetic rat hearts

(2016) Young Hee Shin et al.   HEART AND VESSELS

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications

(2015) Kulbhushan Tikoo et al.   BIOCHEMICAL PHARMACOLOGY

Switch-like Responses of Two Cholesterol Sensors Do Not Require Protein Oligomerization in Membranes

(2015) Austin Gay et al.   BIOPHYSICAL JOURNAL

HIV gp41–mediated membrane fusion occurs at edges of cholesterol-rich lipid domains

(2015) Sung-Tae Yang et al.   Nature Chemical Biology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines

(2010) Michael A. Whitt   JOURNAL OF VIROLOGICAL METHODS

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA