Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism

(2018) Victoria L. Nelson et al.   GENES & DEVELOPMENT

l-Glutamine Attenuates Apoptosis in Porcine Enterocytes by Regulating Glutathione-Related Redox Homeostasis

(2018) Ning Liu et al.   JOURNAL OF NUTRITION

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Amino acid supplements in critically ill patients

(2018) Jan Gunst et al.   PHARMACOLOGICAL RESEARCH

Nonnutritive Effects of Glutamine

(2018) Erich Roth   JOURNAL OF NUTRITION

Clinical Use of Glutamine Supplementation

(2018) Jan Wernerman   JOURNAL OF NUTRITION

The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases

(2017) Min-Hyun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Oral Supplementation of Glutamine Attenuates the Progression of Nonalcoholic Steatohepatitis in C57BL/6J Mice

(2017) Cathrin Sellmann et al.   JOURNAL OF NUTRITION

Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer

(2017) Mark A. White et al.   MOLECULAR CANCER RESEARCH

Dietary Supplements Commonly Used by Cancer Survivors: Are There Any Benefits?

(2017) Mary J. Marian   NUTRITION IN CLINICAL PRACTICE

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism

(2017) Jiang Li et al.   PLoS One

Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli

(2017) Karrera Y. Djoko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

(2017) Hayden Weng Siong Tan et al.   Nature Communications

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

(2017) Luke C. Davies et al.   Nature Communications

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

(2017) Lindsey Araujo et al.   eLife

Metabolism Supports Macrophage Activation

(2017) P. Kent Langston et al.   Frontiers in Immunology

l-glutamine and l-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise

(2016) Jaqueline Santos Moreira Leite et al.   Applied Physiology Nutrition and Metabolism

Regulatory principles in metabolism-then and now

(2016) R. Curi et al.   BIOCHEMICAL JOURNAL

Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise

(2016) Raquel Raizel et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Glutamine effects on heat shock protein 70 and interleukines 6 and 10: Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children

(2016) Iolanda Jordan et al.   CLINICAL NUTRITION

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Glutamine Concentrations in Liver Failure

(2016) Gunnel Helling et al.   PLoS One

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

A Broken Krebs Cycle in Macrophages

(2015) Luke A.J. O’Neill   IMMUNITY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

L-glutamine Supplementations Enhance Liver Glutamine-Glutathione Axis and Heat Shock Factor-1 Expression in Endurance-Exercise Trained Rats

(2015) Éder Ricardo Petry et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Oral Glutamine in Preventing Treatment-Related Mucositis in Adult Patients With Cancer

(2015) Caitlin Sayles et al.   NUTRITION IN CLINICAL PRACTICE

Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway

(2015) Csörsz Nagy et al.   Frontiers in Immunology

Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization

(2014) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Feeding the gut

(2014) Jan Wernerman   Current Opinion in Critical Care

Metabolism of activated T lymphocytes

(2014) Jason A Maciolek et al.   CURRENT OPINION IN IMMUNOLOGY

Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge

(2014) Vinicius Fernandes Cruzat et al.   JOURNAL OF ENDOCRINOLOGY

Amino acid supplementation and impact on immune function in the context of exercise

(2014) Vinicius Fernandes Cruzat et al.   Journal of the International Society of Sports Nutrition

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Alterations in glutamine metabolism and its conversion to citrulline in sepsis

(2013) Christina Kao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats

(2013) Stéphanie Beutheu et al.   CLINICAL NUTRITION

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

Metabolic fuelling of proper T cell functions

(2013) Giuseppe Matarese et al.   IMMUNOLOGY LETTERS

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral supplementations with free and dipeptide forms of l-glutamine in endotoxemic mice: effects on muscle glutamine-glutathione axis and heat shock proteins

(2013) Vinicius F. Cruzat et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: Involvement of heat shock protein pathways

(2013) Éder Ricardo Petry et al.   LIFE SCIENCES

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

A comparative study of short- and long-TE1H MRS at 3 T forin vivodetection of 2-hydroxyglutarate in brain tumors

(2013) Changho Choi et al.   NMR IN BIOMEDICINE

Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia

(2013) Vinicius Fernandes Cruzat et al.   NUTRITION

Anti-fibrotic effect of thymoquinone on hepatic stellate cells

(2013) Mohammed Ghazwani et al.   PHYTOMEDICINE

Effects of glutamine on oxidative stress and nuclear factor-κB expression in the livers of rats with nonalcoholic fatty liver disease

(2013) ZHIHUI LIN et al.   Experimental and Therapeutic Medicine

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation

(2012) Lea Bollhalder et al.   CLINICAL NUTRITION

Glutamine and glutathione at ICU admission in relation to outcome

(2012) Paul Castillo Rodas et al.   CLINICAL SCIENCE

Modulation of the nuclear factor-kappa B (NF-κB) signalling pathway by glutamine in peritoneal macrophages of a murine model of protein malnutrition

(2012) Fabiana da Silva Lima et al.   EUROPEAN JOURNAL OF NUTRITION

Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

(2012) Aditi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Side Effects of Long-Term Glutamine Supplementation

(2012) Milan Holecek   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR

(2012) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?

(2011) Thiago Gomes Heck et al.   CELL BIOCHEMISTRY AND FUNCTION

The effect of l-alanyl-l-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients*

(2011) Teodoro Grau et al.   CRITICAL CARE MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of glutamine on the nuclear factor-kappaB signaling pathway of murine peritoneal macrophages

(2010) Marcelo Macedo Rogero et al.   AMINO ACIDS

Glutamine in Critical Illness: The Time Has Come, The Time Is Now

(2010) Lindsay-Rae B. Weitzel et al.   CRITICAL CARE CLINICS

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

O-Linked β-N-acetylglucosamine (O-GlcNAc) Regulates Stress-induced Heat Shock Protein Expression in a GSK-3β-dependent Manner

(2010) Zahra Kazemi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic  -cells

(2010) M. Lafontaine-Lacasse et al.   JOURNAL OF ENDOCRINOLOGY

The Impact of Glutamine Dipeptide–Supplemented Parenteral Nutrition on Outcomes of Surgical Patients

(2010) Yan Wang et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity

(2009) Christine R. Hamiel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of glutamine supplementation on kidney of diabetic rat

(2009) Tatiana Carolina Alba-Loureiro et al.   AMINO ACIDS

Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise

(2009) Vinicius Fernandes Cruzat et al.   CELL BIOCHEMISTRY AND FUNCTION

Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data

(2009) C M Lenders et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes: can exercise impair the autoimmune event? TheL-arginine/glutamine coupling hypothesis

(2008) Maurício da Silva Krause et al.   CELL BIOCHEMISTRY AND FUNCTION

Human CD4+ T cells maintain specific functions even under conditions of extremely restricted ATP production

(2008) Robert Tripmacher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

BOARD-INVITED REVIEW: Peptide absorption and utilization: Implications for animal nutrition and health

(2008) E. R. Gilbert et al.   JOURNAL OF ANIMAL SCIENCE

Efficacy of Parenteral Nutrition Supplemented With Glutamine Dipeptide to Decrease Hospital Infections in Critically Ill Surgical Patients

(2008) Concepción F. Estívariz et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise

(2008) Vinicius Fernandes Cruzat et al.   NUTRITION

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark