Structure and function of biotin-dependent carboxylases

Reply to Hoehnet al.: Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Urea Carboxylase Provides Insights into the Carboxyltransfer Reaction

(2012) Chen Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice

(2012) Kyle L. Hoehn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

(2012) Scott W. Bagley et al.   JOURNAL OF ORGANIC CHEMISTRY

A single mutation in MCCC1 or MCCC2 as a potential cause of positive screening for 3-methylcrotonyl-CoA carboxylase deficiency

(2012) Raphael J. Morscher et al.   MOLECULAR GENETICS AND METABOLISM

Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis

(2012) Kristen E. N. Scott et al.   PLoS One

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase

(2011) S. W. Polyak et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation

(2011) Hakam Alkhateeb et al.   Applied Physiology Nutrition and Metabolism

Probing the allosteric activation of pyruvate carboxylase using 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA

(2011) Abdussalam Adina-Zada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA

(2011) Abdussalam Adina-Zada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel Insights into the Biotin Carboxylase Domain Reactions of Pyruvate Carboxylase fromRhizobium etli

(2011) Tonya N. Zeczycki et al.   BIOCHEMISTRY

Activation and Inhibition of Pyruvate Carboxylase fromRhizobium etli

(2011) Tonya N. Zeczycki et al.   BIOCHEMISTRY

Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase fromRhizobium etli

(2011) Adam D. Lietzan et al.   BIOCHEMISTRY

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

(2011) Christoffer Bengtsson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors

(2011) Tohru Yamashita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular evolution of urea amidolyase and urea carboxylase in fungi

(2011) Pooja K Strope et al.   BMC EVOLUTIONARY BIOLOGY

Early evolution of the biotin-dependent carboxylase family

(2011) Jonathan Lombard et al.   BMC EVOLUTIONARY BIOLOGY

Role of lipids in the control of food intake

(2011) Marc Fantino   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mechanisms of immune evasion in fungal pathogens

(2011) John R Collette et al.   CURRENT OPINION IN MICROBIOLOGY

Lipogenic Enzymes as Therapeutic Targets for Obesity and Diabetes

(2011) James M. Lenhard   CURRENT PHARMACEUTICAL DESIGN

Genes encoding the biotin carboxylase subunit of acetyl-CoA carboxylase from Brassica napus and parental species: cloning, expression patterns, and evolution

(2011) Zhi-Guo Li et al.   GENOME

Stimulation of Fat Oxidation, but no Sustained Reduction of Hepatic Lipids by Prolonged Pharmacological Inhibition of Acetyl CoA Carboxylase

(2011) M. Glien et al.   HORMONE AND METABOLIC RESEARCH

Deficiencies in acetyl-CoA carboxylase and fatty acid synthase 1 differentially affect eggshell formation and blood meal digestion in Aedes aegypti

(2011) Amy Alabaster et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanism of Resistance to ACCase-Inhibiting Herbicides in Wild Oat (Avena fatua) from Latin America

(2011) Hugo Cruz-Hipolito et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rhodobacter sphaeroides Uses a Reductive Route via Propionyl Coenzyme A To Assimilate 3-Hydroxypropionate

(2011) K. Schneider et al.   JOURNAL OF BACTERIOLOGY

Dimerization of the Bacterial Biotin Carboxylase Subunit Is Required for Acetyl Coenzyme A Carboxylase Activity In Vivo

(2011) A. C. Smith et al.   JOURNAL OF BACTERIOLOGY

AccD6, a Key Carboxyltransferase Essential for Mycolic Acid Synthesis in Mycobacterium tuberculosis, Is Dispensable in a Nonpathogenic Strain

(2011) J. Pawelczyk et al.   JOURNAL OF BACTERIOLOGY

Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization

(2011) Chi-Yuan Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quaternary Structure of the Oxaloacetate Decarboxylase Membrane Complex and Mechanistic Relationships to Pyruvate Carboxylases

(2011) Monica Balsera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion

(2011) Francis Rajamohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian ACSF3 Protein Is a Malonyl-CoA Synthetase That Supplies the Chain Extender Units for Mitochondrial Fatty Acid Synthesis

(2011) Andrzej Witkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition

(2011) Jonathan M. Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uneventful clinical courses of Korean patients with methylcrotonylglycinuria and their common mutations

(2011) Chang-Woo Jung et al.   JOURNAL OF HUMAN GENETICS

Mutation analysis in 54 propionic acidemia patients

(2011) J. P. Kraus et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase

(2011) Kevin D. Freeman-Cook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical characteristization of propionyl-coenzyme a carboxylase complex of Streptomyces toxytricini

(2011) Atanas V. Demirev et al.   JOURNAL OF MICROBIOLOGY

Human Cytomegalovirus Induces the Activity and Expression of Acetyl-Coenzyme A Carboxylase, a Fatty Acid Biosynthetic Enzyme Whose Inhibition Attenuates Viral Replication

(2011) C. M. Spencer et al.   JOURNAL OF VIROLOGY

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Insulin Resistance: the Link Between Obesity and Cardiovascular Disease

(2011) Gerald M. Reaven   MEDICAL CLINICS OF NORTH AMERICA

Association of ACACB polymorphisms with obesity and diabetes

(2011) J.A. Riancho et al.   MOLECULAR GENETICS AND METABOLISM

Requirement for acetyl-CoA carboxylase in Trypanosoma brucei is dependent upon the growth environment

(2011) Patrick A. Vigueira et al.   MOLECULAR MICROBIOLOGY

An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase

(2011) Christine S. Huang et al.   NATURE

Allelic variation of the ACCase gene and response to ACCase-inhibiting herbicides in pinoxaden-resistant Lolium spp.

(2011) Laura Scarabel et al.   PEST MANAGEMENT SCIENCE

Malonyl-CoA Synthetase, Encoded byACYL ACTIVATING ENZYME13, Is Essential for Growth and Development ofArabidopsis

(2011) Hui Chen et al.   PLANT CELL

Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination

(2011) Geng Ding et al.   PLANT JOURNAL

The glossyhead1 Allele of ACC1 Reveals a Principal Role for Multidomain Acetyl-Coenzyme A Carboxylase in the Biosynthesis of Cuticular Waxes by Arabidopsis

(2011) S. Lu et al.   PLANT PHYSIOLOGY

Ammonia oxidation coupled to CO2 fixation by archaea and bacteria in an agricultural soil

(2011) J. Pratscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Methylaspartate Cycle in Haloarchaea

(2011) M. Khomyakova et al.   SCIENCE

Biotechnological potential of the ethylmalonyl-CoA pathway

(2010) Birgit E. Alber   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Catabolism of citronellol and related acyclic terpenoids in pseudomonads

(2010) Karin Förster-Fromme et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation

(2010) Donald B. Jump et al.   BIOCHEMICAL PHARMACOLOGY

Probing the Catalytic Roles of Arg548 and Gln552 in the Carboxyl Transferase Domain of theRhizobium etliPyruvate Carboxylase by Site-Directed Mutagenesis

(2010) Saowapa Duangpan et al.   BIOCHEMISTRY

Structural Impact of Human andEscherichia coliBiotin Carboxyl Carrier Proteins on Biotin Attachment

(2010) Shannon Healy et al.   BIOCHEMISTRY

Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit ofStreptomyces coelicolor,

(2010) Ana Arabolaza et al.   BIOCHEMISTRY

The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity

(2010) Theola Louie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity

(2010) Kyle L. Hoehn et al.   Cell Metabolism

Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells

(2010) Masa-aki Kobayashi et al.   Clinical and Experimental Nephrology

Activation of a peroxisomal Pichia pastoris d-amino acid oxidase, which uses d-alanine as a preferred substrate, depends on pyruvate carboxylase

(2010) Sandra H. Klompmaker et al.   FEMS YEAST RESEARCH

Genes encoding the α-carboxyltransferase subunit of acetyl-CoA carboxylase from Brassica napus and parental species: cloning, expression patterns, and evolution

(2010) Zhi-Guo Li et al.   GENOME

A herbicide-resistant ACCase 1781 Setaria mutant shows higher fitness than wild type

(2010) T Wang et al.   HEREDITY

Adeno-Associated Virus Serotype 8 Gene Transfer Rescues a Neonatal Lethal Murine Model of Propionic Acidemia

(2010) Randy J. Chandler et al.   HUMAN GENE THERAPY

My favorite pyruvate carboxylase

(2010) John C. Wallace   IUBMB LIFE

Pyruvate Carboxylase Plays a Crucial Role in Carbon Metabolism of Extra- and Intracellularly Replicating Listeria monocytogenes

(2010) J. Schar et al.   JOURNAL OF BACTERIOLOGY

Amino acid metabolism in patients with propionic acidaemia

(2010) Sabine Scholl-Bürgi et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The molecular landscape of propionic acidemia and methylmalonic aciduria in Latin America

(2010) Belén Pérez et al.   JOURNAL OF INHERITED METABOLIC DISEASE

ACC2gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat

(2010) Catherine M. Phillips et al.   JOURNAL OF LIPID RESEARCH

Identification and Synthesis of Novel Inhibitors of Acetyl-CoA Carboxylase with in Vitro and in Vivo Efficacy on Fat Oxidation

(2010) Stefanie Keil et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Structure of an Antikinase and its Inhibitor

(2010) David A. Jacques et al.   JOURNAL OF MOLECULAR BIOLOGY

Megadalton Complexes in the Chloroplast Stroma ofArabidopsis thalianaCharacterized by Size Exclusion Chromatography, Mass Spectrometry, and Hierarchical Clustering

(2010) Paul Dominic B. Olinares et al.   MOLECULAR & CELLULAR PROTEOMICS

Pyruvate carboxylase deficiency: Mechanisms, mimics and anaplerosis

(2010) Isaac Marin-Valencia et al.   MOLECULAR GENETICS AND METABOLISM

Novel mutations in the human MCCA and MCCB gene causing methylcrotonylglycinuria

(2010) Khue Vu Nguyen et al.   MOLECULAR GENETICS AND METABOLISM

Overexpression of adapted U1snRNA in patients' cells to correct a 5′ splice site mutation in propionic acidemia

(2010) Rocío Sánchez-Alcudia et al.   MOLECULAR GENETICS AND METABOLISM

Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase

(2010) Christine S. Huang et al.   NATURE

Autotrophic carbon fixation in archaea

(2010) Ivan A. Berg et al.   NATURE REVIEWS MICROBIOLOGY

The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes

(2010) S. C. W. Tang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

An aspartate to glycine change in the carboxyl transferase domain of acetyl CoA carboxylase and non-target-site mechanism(s) confer resistance to ACCase inhibitor herbicides in a Lolium multiflorum population

(2010) Shiv Shankhar Kaundun   PEST MANAGEMENT SCIENCE

The action of herbicides on fatty acid biosynthesis and elongation in barley and cucumber

(2010) Xueying Yang et al.   PEST MANAGEMENT SCIENCE

Reverse-Genetic Analysis of the Two Biotin-Containing Subunit Genes of the Heteromeric Acetyl-Coenzyme A Carboxylase in Arabidopsis Indicates a Unidirectional Functional Redundancy

(2010) X. Li et al.   PLANT PHYSIOLOGY

Constituents of Cinnamon Inhibit Bacterial Acetyl CoA Carboxylase

(2010) Glen Meades et al.   PLANTA MEDICA

Methanol Assimilation in Methylobacterium extorquens AM1: Demonstration of All Enzymes and Their Regulation

(2010) Hana Šmejkalová et al.   PLoS One

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity

(2010) J. Marjanovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

(2010) D. P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden

(2010) L. P. C. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

(2010) C.-W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Spot 14, a modulator of fatty acid synthesis

(2010) C. L. Colbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of the backbone dynamics of the apo- and holo-carboxy-terminal domain of the biotin carboxy1 carrier subunit of Escherichia coli acety1-CoA carboxylase

(2010) Xiang Yao et al.   PROTEIN SCIENCE

Cryo-EM Analysis Reveals New Insights into the Mechanism of Action of Pyruvate Carboxylase

(2010) Gorka Lasso et al.   STRUCTURE

A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes

(2010) Shiro Maeda et al.   PLoS Genetics

Smaller Is Better for Antibiotic Discovery

(2009) Grover L. Waldrop   ACS Chemical Biology

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

(2009) Igor Mochalkin et al.   ACS Chemical Biology

A Single Nucleotide Polymorphism of Chicken Acetyl-CoA Carboxylase A Gene Associated with Fatness Traits

(2009) Jianwei Tian et al.   ANIMAL BIOTECHNOLOGY

Polymorphism of the pigacetyl-coenzyme A carboxylase αgene is associated with fatty acid composition in a Duroc commercial line

(2009) D. Gallardo et al.   ANIMAL GENETICS

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insight into the Carboxyl Transferase Domain Mechanism of Pyruvate Carboxylase fromRhizobium etli

(2009) Tonya N. Zeczycki et al.   BIOCHEMISTRY

Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics

(2009) Virendar K. Kaushik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden

(2009) Michel Muehlebach et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase

(2009) Brian Raymer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of antibacterial AccC inhibitors

(2009) Cliff C. Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

(2009) Jeffrey W. Corbett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production inEscherichia coli

(2009) Haoran Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

(2009) Michelle L Tomaszycki et al.   BMC NEUROSCIENCE

Mass Spectrometry in High Throughput Screening: A Case Study on Acetyl-Coenzyme A Carboxylase using RapidFire® – Mass Spectrometry (RF-MS)

(2009) Maxine Jonas et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet

(2009) M. Schreurs et al.   DIABETES OBESITY & METABOLISM

Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes

(2009) Sebastian Kreuz et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007 – 2008

(2009) Jeffrey W Corbett   EXPERT OPINION ON THERAPEUTIC PATENTS

Evolutionary aspects of urea utilization by fungi

(2009) Dhammika H.M.L.P. Navarathna et al.   FEMS YEAST RESEARCH

Short-Term Rescue of Neonatal Lethality in a Mouse Model of Propionic Acidemia by Gene Therapy

(2009) Sean E. Hofherr et al.   HUMAN GENE THERAPY

Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency

(2009) Sophie Monnot et al.   HUMAN MUTATION

Arginine-Induced Germ Tube Formation in Candida albicans Is Essential for Escape from Murine Macrophage Line RAW 264.7

(2009) S. Ghosh et al.   INFECTION AND IMMUNITY

Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism

(2009) Chi-Yuan Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Asymmetric Model for Na+-translocating Glutaconyl-CoA Decarboxylases

(2009) Daniel Kress et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryptic Exon Activation by Disruption of Exon Splice Enhancer

(2009) Martin Stucki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

(2009) D. G. Kurth et al.   MICROBIOLOGY-SGM

High frequency of large genomic deletions in the PCCA gene causing propionic acidemia

(2009) Lourdes R. Desviat et al.   MOLECULAR GENETICS AND METABOLISM

Epilepsy in Patients with Propionic Acidemia

(2009) E. Haberlandt et al.   NEUROPEDIATRICS

Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain

(2009) D. Ballhausen et al.   NEUROSCIENCE

A tale of two functions: enzymatic activity and translational repression by carboxyltransferase

(2009) Glen Meades et al.   NUCLEIC ACIDS RESEARCH

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

ACC2 Is Expressed at High Levels Human White Adipose and Has an Isoform with a Novel N-Terminus

(2009) John C. Castle et al.   PLoS One

Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit

(2009) A. B. Feria Bourrellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

(2009) J. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim

(2009) S. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial fatty acid synthesis – An adopted set of enzymes making a pathway of major importance for the cellular metabolism

(2009) J. Kalervo Hiltunen et al.   PROGRESS IN LIPID RESEARCH

Acetyl-coenzyme A carboxylase α gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels

(2009) Francisco J. Diaz et al.   SCHIZOPHRENIA RESEARCH

A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A

(2009) Linda P.C. Yu et al.   STRUCTURE

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

(2008) M. Faadiel Essop et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells

(2008) David Saggerson   Annual Review of Nutrition

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate

(2008) Gregory A. Locke et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex

(2008) H. Ray et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure, mechanism and regulation of pyruvate carboxylase

(2008) Sarawut Jitrapakdee et al.   BIOCHEMICAL JOURNAL

Structural Evidence for Direct Interactions between the BRCT Domains of Human BRCA1 and a Phospho-peptide from Human ACC1†

(2008) Yang Shen et al.   BIOCHEMISTRY

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

Regulation of food intake and energy expenditure by hypothalamic malonyl-CoA

(2008) M D Lane et al.   INTERNATIONAL JOURNAL OF OBESITY

Substrate Specificity of the 3-Methylcrotonyl Coenzyme A (CoA) and Geranyl-CoA Carboxylases from Pseudomonas aeruginosa

(2008) J. A. Aguilar et al.   JOURNAL OF BACTERIOLOGY

Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

(2008) Noaman M. Hasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism

(2008) Sarah M. Ronnebaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Single Nucleotide Polymorphisms in Promoter III of the Acetyl-CoA Carboxylase-  Gene in Goats Affecting Milk Production Traits

(2008) S. Federica et al.   JOURNAL OF HEREDITY

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes

(2008) Gorm Andersen et al.   JOURNAL OF MOLECULAR BIOLOGY

The molecular basis of pyruvate carboxylase deficiency: Mosaicism correlates with prolonged survival

(2008) Dong Wang et al.   MOLECULAR GENETICS AND METABOLISM

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

(2008) Song Xiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cross-resistance patterns to ACCase-inhibiting herbicides conferred by mutant ACCase isoforms inAlopecurus myosuroidesHuds. (black-grass), re-examined at the recommended herbicide field rate

(2008) Christophe Délye et al.   PEST MANAGEMENT SCIENCE

Acc homoeoloci and the evolution of wheat genomes

(2008) D. Chalupska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

(2008) Igor Mochalkin et al.   PROTEIN SCIENCE

Biotinoyl domain of human acetyl-CoA carboxylase: Structural insights into the carboxyl transfer mechanism

(2008) Chung-Kyung Lee et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The utility of molecular dynamics simulations for understanding site-directed mutagenesis of glycine residues in biotin carboxylase

(2008) Tee Bordelon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS