Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts

Compartmentation of β 2 ‐Adrenergic Receptor Stimulated cAMP Responses by Phosphodiesterases Type 2 and 3 in Cardiac Ventricular Myocytes

(2021) Michael W. Rudokas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiological And Pathological Roles Of Protein Kinase A In The Heart

(2021) Yuening Liu et al.   CARDIOVASCULAR RESEARCH

CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload–Induced Heart Failure

(2021) Daniel A. Richards et al.   Circulation-Heart Failure

CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI – difference from BNP visualized by targeted cGMP biosensors

(2021) Ornella Manfra et al.   CARDIOVASCULAR RESEARCH

cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias

(2021) Filip Berisha et al.   CIRCULATION RESEARCH

Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes

(2021) Kimberly J. McCabe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PDE1 Inhibition Modulates Ca v 1.2 Channel to Stimulate Cardiomyocyte Contraction

(2021) Grace K Muller et al.   CIRCULATION RESEARCH

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2021) Theresa A McDonagh et al.   EUROPEAN HEART JOURNAL

Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure

(2020) Sarah Karam et al.   CIRCULATION

Targets of cGMP/cGKI in cardiac myocytes

(2020) Julia Adler et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

(2020) Paul W. Armstrong et al.   NEW ENGLAND JOURNAL OF MEDICINE

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

(2020) Sophie Schobesberger et al.   eLife

Extended‐Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction

(2020) Shane Nanayakkara et al.   Journal of the American Heart Association

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Optical Mapping of cAMP Signaling at the Nanometer Scale

(2020) Andreas Bock et al.   CELL

Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy

(2020) Aniella Abi-Gerges et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation

(2020) Bernardo Dolce et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness

(2020) Konstanze Michel et al.   JCI Insight

Subcellular Organization of the cAMP Signaling Pathway

(2020) Manuela Zaccolo et al.   PHARMACOLOGICAL REVIEWS

Posttranslational modifications of titin from cardiac muscle: how, where, and what for?

(2019) Franziska Koser et al.   FEBS Journal

Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response

(2019) Marie-Victoire Cosson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

(2019) Michael Lawless et al.   Scientific Reports

Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model

(2019) Delphine Mika et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of Sacubitril-Valsartan, versus Valsartan, in Women Compared to Men with Heart Failure and Preserved Ejection Fraction: Insights from PARAGON-HF

(2019) John J. V. McMurray et al.   CIRCULATION

Myocardial Phosphodiesterases and their Role in cGMP Regulation

(2019) Brittany Dunkerly-Eyring et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction

(2019) Si Chen et al.   CIRCULATION

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: A Translational Study in the Dog and Rabbit

(2018) Toru Hashimoto et al.   CIRCULATION

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure

(2018) Reshma S. Baliga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

(2018) Hariharan Subramanian et al.   Nature Communications

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β 2 AR-cAMP Responsiveness in Murine Hearts

(2018) Peter T. Wright et al.   Cell Reports

Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro

(2018) Anastacia M. Garcia et al.   Circulation-Heart Failure

PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts

(2017) Silja Meier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling

(2017) Andreas Koschinski et al.   Scientific Reports

Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model

(2016) Chun-kai Huang et al.   ACTA PHARMACOLOGICA SINICA

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

(2016) Mark Richards et al.   CARDIOVASCULAR RESEARCH

Location, location, location: PDE4D5 function is directed by its unique N-terminal region

(2016) Lauren Wills et al.   CELLULAR SIGNALLING

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial InfarctionNovelty and Significance

(2016) Christiane Vettel et al.   CIRCULATION RESEARCH

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

(2016) Walter E. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Popeye domain containing protein family – A novel class of cAMP effectors with important functions in multiple tissues

(2016) Roland F.R. Schindler et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes

(2015) Andrea M. Isidori et al.   CARDIOVASCULAR RESEARCH

Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of  -Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy

(2015) R. K. Perera et al.   CIRCULATION RESEARCH

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

(2015) Anna Zoccarato et al.   CIRCULATION RESEARCH

Regulation of Sarcoplasmic Reticulum Ca2+ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium

(2015) Faiyaz Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway

(2015) Claire Y. Zhao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury

(2015) Youn Wook Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo model with targeted cAMP biosensor reveals changes in receptor–microdomain communication in cardiac disease

(2015) Julia U. Sprenger et al.   Nature Communications

PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways

(2014) C. Vettel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human cardiac troponin complex. Structure and functions

(2014) I. A. Katrukha   BIOCHEMISTRY-MOSCOW

Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension

(2014) Kristen J. Bubb et al.   CIRCULATION

Transgenic Mice for Real-Time Visualization of cGMP in Intact Adult Cardiomyocytes

(2014) Konrad R. Götz et al.   CIRCULATION RESEARCH

PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects

(2014) Fernando Soler et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

PDE5 inhibitor sildenafil in the treatment of heart failure: A meta-analysis of randomized controlled trials

(2014) Xiao-Dong Zhuang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation

(2014) Yassine Sassi et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-classical regulation of β1- and β2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi

(2014) Caroline Bull Melsom et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium

(2014) Lise Román Moltzau et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

(2014) Peter Molenaar et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gi Proteins Regulate Adenylyl Cyclase Activity Independent of Receptor Activation

(2014) Caroline Bull Melsom et al.   PLoS One

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

(2014) E. Patrucco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDE4 in the human heart - major player or little helper?

(2013) Thomas Eschenhagen   BRITISH JOURNAL OF PHARMACOLOGY

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

(2013) L R Moltzau et al.   BRITISH JOURNAL OF PHARMACOLOGY

PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

(2013) Peter Molenaar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential regulation of cardiac excitation–contraction coupling by cAMP phosphodiesterase subtypes

(2013) Delphine Mika et al.   CARDIOVASCULAR RESEARCH

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling

(2013) Peter T. Wright et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility

(2013) Finn Olav Levy   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium

(2013) Sabine Weninger et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling

(2013) Sara Vandenwijngaert et al.   PLoS One

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling

(2012) Manling Zhang et al.   CIRCULATION

Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart

(2012) Sanja Beca et al.   CIRCULATION RESEARCH

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

(2012) Cristina E. Molina et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig

(2012) W.B. Johnson et al.   LIFE SCIENCES

Study of the regulation of the inotropic response to 5-HT4 receptor activation via phosphodiesterases and its cross-talk with C-type natriuretic peptide in porcine left atrium

(2012) S. Weninger et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

(2011) Marco Guazzi et al.   CIRCULATION

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

(2011) Alessandra Stangherlin et al.   CIRCULATION RESEARCH

Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current

(2011) Sanja Beca et al.   CIRCULATION RESEARCH

Differential Expression of PDE5 in Failing and Nonfailing Human Myocardium

(2011) Xiaoyin Shan et al.   Circulation-Heart Failure

Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I

(2011) Stefan Frantz et al.   EUROPEAN HEART JOURNAL

Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

(2011) Jérôme Leroy et al.   JOURNAL OF CLINICAL INVESTIGATION

Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

(2011) David A. MacDougall et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle

(2011) Faraz Afzal et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Conserved expression and functions of PDE4 in rodent and human heart

(2010) Wito Richter et al.   BASIC RESEARCH IN CARDIOLOGY

Differential regulation of β2-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle

(2010) Faraz Afzal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes

(2010) Liliana R.V. Castro et al.   CIRCULATION RESEARCH

Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

(2010) Enrico Patrucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Natriuretic peptides increase β1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition

(2009) Eirik Qvigstad et al.   CARDIOVASCULAR RESEARCH

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

(2009) Peter Pokreisz et al.   CIRCULATION

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals

(2009) Aniella Abi-Gerges et al.   CIRCULATION RESEARCH

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

Dual Acylation of PDE2A Splice Variant 3

(2009) Corina Russwurm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Cytoplasmic cAMP concentrations in intact cardiac myocytes

(2008) Radu V. Iancu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles

(2008) F Afzal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes

(2008) Manling Zhang et al.   CELLULAR SIGNALLING

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

Tackling heart failure in the twenty-first century

(2008) James O. Mudd et al.   NATURE

B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function

(2008) R. Sodi et al.   REGULATORY PEPTIDES

Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)-adrenaline mediated through mouse cardiac β1-adrenoceptors

(2007) A Galindo-Tovar et al.   BRITISH JOURNAL OF PHARMACOLOGY