Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

(2019) Faisa Omar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model

(2019) Delphine Mika et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+waves induced by cAMP-phosphodiesterase inhibitors

(2016) Pierre Bobin et al.   CARDIOVASCULAR RESEARCH

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

(2015) Anna Zoccarato et al.   CIRCULATION RESEARCH

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

PDE4B mediates local feedback regulation of  1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes

(2014) D. Mika et al.   JOURNAL OF CELL SCIENCE

Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

(2014) Peter Molenaar et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

(2013) Peter Molenaar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcineurin activity is required for cardiac remodelling in pregnancy

(2013) Eunhee Chung et al.   CARDIOVASCULAR RESEARCH

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury

(2013) Masayoshi Oikawa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases

(2012) Alessandra Ghigo et al.   CIRCULATION

Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current

(2011) Sanja Beca et al.   CIRCULATION RESEARCH

Conserved expression and functions of PDE4 in rodent and human heart

(2010) Wito Richter et al.   BASIC RESEARCH IN CARDIOLOGY

β-Adrenergic stimulation and myocardial function in the failing heart

(2009) Ali El-Armouche et al.   HEART FAILURE REVIEWS

Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes

(2008) Jérôme Leroy et al.   CIRCULATION RESEARCH

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation

(2008) Norbert Frey et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)-adrenaline mediated through mouse cardiac β1-adrenoceptors

(2007) A Galindo-Tovar et al.   BRITISH JOURNAL OF PHARMACOLOGY