Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Computational modeling approaches to cAMP/PKA signaling in cardiomyocytes
Authors
Keywords
-
Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 154, Issue -, Pages 32-40
Publisher
Elsevier BV
Online
2021-02-04
DOI
10.1016/j.yjmcc.2021.01.008
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Studying signal compartmentation in adult cardiomyocytes
- (2020) Aleksandra Judina et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Interplay Between β-Adrenergic Stimulation and CaMKII Signaling Favors Human Atrial Arrhythmogenesis: Insights from Populations of Models
- (2020) Haibo Ni et al. BIOPHYSICAL JOURNAL
- Spatially Compartmentalized Phase Regulation in the Ca2+-cAMP-PKA-Oscillatory Circuit
- (2020) Brian Tenner et al. BIOPHYSICAL JOURNAL
- Quantification of uncertainty in a new network model of pulmonary arterial adventitial fibroblast pro-fibrotic signalling
- (2020) Ariel Wang et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling
- (2020) Shulin Cao et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- An audit of uncertainty in multi-scale cardiac electrophysiology models
- (2020) Richard H. Clayton et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Considering discrepancy when calibrating a mechanistic electrophysiology model
- (2020) Chon Lok Lei et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Sensitivity and Uncertainty Analysis of Two Human Atrial Cardiac Cell Models Using Gaussian Process Emulators
- (2020) Sam Coveney et al. Frontiers in Physiology
- Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling
- (2020) Jingqi Q.X. Gong et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A Mathematical Model of the Mouse Atrial Myocyte With Inter-Atrial Electrophysiological Heterogeneity
- (2020) Henggui Zhang et al. Frontiers in Physiology
- Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling
- (2020) Jason Z. Zhang et al. CELL
- Optical Mapping of cAMP Signaling at the Nanometer Scale
- (2020) Andreas Bock et al. CELL
- Protein Kinase A as a Promising Target for Heart Failure Drug Development
- (2019) Nancy S. Saad et al. ARCHIVES OF MEDICAL RESEARCH
- cAMP/PKA signaling compartmentalization in cardiomyocytes: Lessons from FRET-based biosensors
- (2019) Alessandra Ghigo et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Geometric Control of Frequency Modulation of cAMP Oscillations due to Calcium in Dendritic Spines
- (2019) Donya Ohadi et al. BIOPHYSICAL JOURNAL
- The Role of Cyclic AMP Signaling in Cardiac Fibrosis
- (2019) Marion Delaunay et al. Cells
- A spatially explicit model shows how titin stiffness modulates muscle mechanics and energetics
- (2018) Joseph Powers et al. INTEGRATIVE AND COMPARATIVE BIOLOGY
- Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane
- (2018) Alex Burdyga et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging
- (2018) Claudio de Lucia et al. Frontiers in Pharmacology
- Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
- (2018) Terje R Kolstad et al. eLife
- Degradation of T-Tubular Microdomains and Altered cAMP Compartmentation Lead to Emergence of Arrhythmogenic Triggers in Heart Failure Myocytes: An in silico Study
- (2018) Alexandra D. Loucks et al. Frontiers in Physiology
- Investigating β-adrenergic-induced cardiac hypertrophy through computational approach: classical and non-classical pathways
- (2017) Ali Khalilimeybodi et al. Journal of Physiological Sciences
- Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity
- (2017) Stefan Neef et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Cardiac T-Tubule Microanatomy and Function
- (2017) TingTing Hong et al. PHYSIOLOGICAL REVIEWS
- Experimental and mathematical analysis of cAMP nanodomains
- (2017) Christian Lohse et al. PLoS One
- Simulation of the effects of moderate stimulation/inhibition of the β1-adrenergic signaling system and its components in mouse ventricular myocytes
- (2016) Mark Grinshpon et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes
- (2016) Mark Richards et al. CARDIOVASCULAR RESEARCH
- Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart FailureClinical Perspective
- (2016) Issam H. Abu-Taha et al. CIRCULATION
- Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart FailureNovelty and Significance
- (2016) Federica Barbagallo et al. CIRCULATION RESEARCH
- Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart FailureNovelty and Significance
- (2016) Jose L. Sanchez-Alonso et al. CIRCULATION RESEARCH
- Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation
- (2016) Jessica GH Bruystens et al. JOURNAL OF MOLECULAR BIOLOGY
- Mechanisms Restricting Diffusion of Intracellular cAMP
- (2016) Shailesh R. Agarwal et al. Scientific Reports
- A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation
- (2016) Pei-Chi Yang et al. PLoS Computational Biology
- Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance
- (2015) Anna Zoccarato et al. CIRCULATION RESEARCH
- Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach
- (2015) Takehisa Kamide et al. Journal of Physiological Sciences
- Multilevel Monte Carlo methods
- (2015) Michael B. Giles ACTA NUMERICA
- Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy
- (2014) Abeer Rababa'h et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding
- (2014) Britton W. Boras et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+loading and CaMKII
- (2014) S. Morotti et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cyclic AMP synthesis and hydrolysis in the normal and failing heart
- (2014) Aziz Guellich et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- A Compartmentalized Mathematical Model of the β1-Adrenergic Signaling System in Mouse Ventricular Myocytes
- (2014) Vladimir E. Bondarenko PLoS One
- Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state
- (2013) Young Soo Han et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Mitochondrial Ca2+ Uptake Induces Cyclic AMP Generation in the Matrix and Modulates Organelle ATP Levels
- (2013) Giulietta Di Benedetto et al. Cell Metabolism
- Adenylyl Cyclase Subtype–Specific Compartmentalization
- (2013) Valeriy Timofeyev et al. CIRCULATION RESEARCH
- Calcium cycling proteins and heart failure: mechanisms and therapeutics
- (2013) Andrew R. Marks JOURNAL OF CLINICAL INVESTIGATION
- Perspectives on: Cyclic nucleotide microdomains and signaling specificity
- (2013) Jeffrey W. Karpen JOURNAL OF GENERAL PHYSIOLOGY
- Can we decipher the information content contained within cyclic nucleotide signals?
- (2013) Thomas C. Rich et al. JOURNAL OF GENERAL PHYSIOLOGY
- Mechanisms of cyclic AMP compartmentation revealed by computational models
- (2013) Jeffrey J. Saucerman et al. JOURNAL OF GENERAL PHYSIOLOGY
- PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling
- (2013) Jason H. Yang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Uncertainty Analysis of Ventricular Mechanics Using the Probabilistic Collocation Method
- (2012) H. Osnes et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Critical role of cardiac t-tubule system for the maintenance of contractile function revealed by a 3D integrated model of cardiomyocytes
- (2012) Asuka Hatano et al. JOURNAL OF BIOMECHANICS
- Mitochondria in cardiac hypertrophy and heart failure
- (2012) Mariana G. Rosca et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit
- (2012) Johan Hake et al. JOURNAL OF PHYSIOLOGY-LONDON
- Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells
- (2011) Wei P. Feinstein et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Cardiac Position Sensitivity Study in the Electrocardiographic Forward Problem Using Stochastic Collocation and Boundary Element Methods
- (2011) Darrell J. Swenson et al. ANNALS OF BIOMEDICAL ENGINEERING
- Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of complex IV
- (2011) Mariana Rosca et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- A comprehensive framework for verification, validation, and uncertainty quantification in scientific computing
- (2011) Christopher J. Roy et al. COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
- CaMKII in myocardial hypertrophy and heart failure
- (2011) Mark E. Anderson et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient
- (2011) Jordi Heijman et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Reorganized PKA-AKAP associations in the failing human heart
- (2011) Thin-Thin Aye et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype
- (2011) S. G. Campbell et al. Journal of the Royal Society Interface
- FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells
- (2011) Sebastian Börner et al. Nature Protocols
- Cardiac myocytes and local signaling in nano-domains
- (2011) Raimond L. Winslow et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- G s-Biased 2-Adrenergic Receptor Signaling from Restoring Synchronous Contraction in the Failing Heart
- (2011) K. Chakir et al. Science Translational Medicine
- Control of Ca2+ Release by Action Potential Configuration in Normal and Failing Murine Cardiomyocytes
- (2010) William E. Louch et al. BIOPHYSICAL JOURNAL
- Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling
- (2010) Anthony R. Soltis et al. BIOPHYSICAL JOURNAL
- Coupling of Adjacent Tropomyosins Enhances Cross-Bridge-Mediated Cooperative Activation in a Markov Model of the Cardiac Thin Filament
- (2010) Stuart G. Campbell et al. BIOPHYSICAL JOURNAL
- The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations
- (2010) Rodrigo F. Oliveira et al. PLoS One
- 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation
- (2010) V. O. Nikolaev et al. SCIENCE
- Calcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion Channels
- (2009) Donald M Bers et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Cytoplasmic cAMP concentrations in intact cardiac myocytes
- (2008) Radu V. Iancu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Phospholemman-Mediated Activation of Na/K-ATPase Limits [Na] i and Inotropic State During β-Adrenergic Stimulation in Mouse Ventricular Myocytes
- (2008) Sanda Despa et al. CIRCULATION
- CaMKII and Its Role in Cardiac Arrhythmia
- (2008) JEFFREY R. ERICKSON et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Simulation analysis of intracellular Na+ and Cl− homeostasis during β1-adrenergic stimulation of cardiac myocyte
- (2007) Masanori Kuzumoto et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More