Human cardiac troponin complex. Structure and functions

Cardiac Troponin T

(2013) Matthias Mueller et al.   CIRCULATION JOURNAL

Integration of Troponin I Phosphorylation With Cardiac Regulatory Networks

(2013) R. John Solaro et al.   CIRCULATION RESEARCH

Interplay between the overlapping ends of tropomyosin and the N terminus of cardiac troponin T affects tropomyosin states on actin

(2013) Ranganath Mamidi et al.   FASEB JOURNAL

The Tropomyosin Binding Region of Cardiac Troponin T Modulates Crossbridge Recruitment Dynamics in Rat Cardiac Muscle Fibers

(2013) Sampath K. Gollapudi et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes

(2012) Paul J. M. Wijnker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular mechanism of actin-myosin motor in muscle

(2012) N. A. Koubassova et al.   BIOCHEMISTRY-MOSCOW

Tropomyosin: Double helix from the protein world

(2012) I. A. Nevzorov et al.   BIOCHEMISTRY-MOSCOW

The C-Terminus of Troponin T Is Essential for Maintaining the Inactive State of Regulated Actin

(2012) Andrew J. Franklin et al.   BIOPHYSICAL JOURNAL

The N-Terminal Extension of Cardiac Troponin T Stabilizes the Blocked State of Cardiac Thin Filament

(2012) Sampath K. Gollapudi et al.   BIOPHYSICAL JOURNAL

Interaction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H

(2012) Sandra E. Pineda-Sanabria et al.   CARDIOVASCULAR RESEARCH

Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

(2012) Pingbo Zhang et al.   CIRCULATION

Third Universal Definition of Myocardial Infarction

(2012) Kristian Thygesen et al.   CIRCULATION

AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes

(2012) Sandra Marisa Oliveira et al.   CIRCULATION RESEARCH

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates

(2012) Alison Kurimchak et al.   GENE

Towards appreciating appropriate clinical responses to highly sensitive cardiac troponin assays

(2012) A. Bima et al.   INTERNAL MEDICINE JOURNAL

A Mutation inTNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation

(2012) Michelle S. Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A

(2012) Aaron C. Hinken et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Dynamics and Calcium Association to the N-Terminal Regulatory Domain of Human Cardiac Troponin C: A Multiscale Computational Study

(2012) Steffen Lindert et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cardiac Actions of Protein Kinase C Isoforms

(2012) Susan F. Steinberg   PHYSIOLOGY

Structural Dynamics of Troponin I during Ca2+-Activation of Cardiac Thin Filaments: A Multi-Site Förster Resonance Energy Transfer Study

(2012) Hui Wang et al.   PLoS One

Republished: Sensitive troponin assays

(2012) Paul O Collinson   POSTGRADUATE MEDICAL JOURNAL

Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity

(2012) Cathrine Husberg et al.   PROTEOMICS

Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain

(2011) Deborah B. Diercks et al.   AMERICAN HEART JOURNAL

Structure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptation

(2011) Zhiling Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phosphorylation, but Not Alternative Splicing or Proteolytic Degradation, Is Conserved in Human and Mouse Cardiac Troponin T

(2011) Jiang Zhang et al.   BIOCHEMISTRY

A Model of Calcium Activation of the Cardiac Thin Filament

(2011) Edward P. Manning et al.   BIOCHEMISTRY

Novel frameshift mutation in Troponin C ( TNNC1) associated with hypertrophic cardiomyopathy and sudden death

(2011) Wendy K. Chung et al.   CARDIOLOGY IN THE YOUNG

Ischemic ventricular arrhythmias: Experimental models and their clinical relevance

(2011) José M. Di Diego et al.   HEART RHYTHM

Augmented Phosphorylation of Cardiac Troponin I in Hypertensive Heart Failure

(2011) Xintong Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Dynamics of C-domain of Cardiac Troponin I Protein in Reconstituted Thin Filament

(2011) Zhiqun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 3-state model of muscle regulation revisited: is a fourth state involved?

(2011) Sherwin S. Lehrer   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Top-Down Quantitative Proteomics Identified Phosphorylation of Cardiac Troponin I as a Candidate Biomarker for Chronic Heart Failure

(2011) Jiang Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Diastolic myofilament dysfunction in the failing human heart

(2011) Jolanda van der Velden   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I

(2011) Raquel Sancho Solis et al.   PROTEIN SCIENCE

Localization of the two tropomyosin-binding sites of troponin T

(2010) J.-P. Jin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function

(2010) Bin Wei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

World Health Organization definition of myocardial infarction: 2008-09 revision

(2010) S. Mendis et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mechanism of Regulation of Native Cardiac Muscle Thin Filaments by Rigor Cardiac Myosin-S1 and Calcium

(2010) Ahmed Houmeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase A–induced myofilament desensitization to Ca2+as a result of phosphorylation of cardiac myosin–binding protein C

(2010) Peter P. Chen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Myofilament length dependent activation

(2010) Pieter P. de Tombe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Analysis of the sarcomere protein gene mutation on cardiomyopathy – Mutations in the cardiac troponin I gene

(2010) Chikako Murakami et al.   Legal Medicine

Is there nascent structure in the intrinsically disordered region of troponin I?

(2010) Olivier Julien et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

(2009) Viola Kooij et al.   BASIC RESEARCH IN CARDIOLOGY

Impact of Cardiac Troponin T N-Terminal Deletion and Phosphorylation on Myofilament Function

(2009) Marius P. Sumandea et al.   BIOCHEMISTRY

In VivoPhosphorylation Site Mapping in Mouse Cardiac Troponin I by High Resolution Top-Down Electron Capture Dissociation Mass Spectrometry: Ser22/23 Are the Only Sites Basally Phosphorylated

(2009) Serife Ayaz-Guner et al.   BIOCHEMISTRY

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Left Ventricular and Myocardial Function in Mice Expressing Constitutively Pseudophosphorylated Cardiac Troponin I

(2009) Jonathan A. Kirk et al.   CIRCULATION RESEARCH

The C Terminus of Cardiac Troponin I Stabilizes the Ca 2+ -Activated State of Tropomyosin on Actin Filaments

(2009) Agnieszka Galińska et al.   CIRCULATION RESEARCH

Analytic and Clinical Utility of a Next-Generation, Highly Sensitive Cardiac Troponin I Assay for Early Detection of Myocardial Injury

(2009) P. A. Kavsak et al.   CLINICAL CHEMISTRY

Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology

(2009) Persoulla Nicolaou   Frontiers in Bioscience-Landmark

Förster Resonance Energy Transfer Structural Kinetic Studies of Cardiac Thin Filament Deactivation

(2009) Jun Xing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry

(2009) Devanand Kowlessur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ala Scanning of the Inhibitory Region of Cardiac Troponin I

(2009) Tomoyoshi Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase A–dependent modulation of Ca2+sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin

(2009) Douchi Matsuba et al.   JOURNAL OF GENERAL PHYSIOLOGY

Phosphorylation and function of cardiac myosin binding protein-C in health and disease

(2009) David Barefield et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

(2009) Ruth H. Willott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top–down tandem mass spectrometry

(2009) Raquel Sancho Solis et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Raf-1: a novel cardiac troponin T kinase

(2009) Paul Pfleiderer et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The nature of the globular- to fibrous-actin transition

(2009) Toshiro Oda et al.   NATURE

Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays

(2009) Tobias Reichlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypertrophic Cardiomyopathy

(2009) JEFFREY A. TOWBIN   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Interaction of cardiac troponin with cardiotonic drugs: A structural perspective

(2008) Monica X. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcription factor Yin Yang 1 represses fetal troponin I gene expression in neonatal myocardial cells

(2008) Changlong Nan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1

(2008) Bei You et al.   BIOCHEMICAL JOURNAL

Coding Sequence Mutations Identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 Patients with Familial or Idiopathic Dilated Cardiomyopathy

(2008) Ray E. Hershberger et al.   CTS-Clinical and Translational Science

Tyrosine Phosphorylation Modifies Protein Kinase C δ-dependent Phosphorylation of Cardiac Troponin I

(2008) Marius P. Sumandea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C Contributes to the Maintenance of Contractile Force in Human Ventricular Cardiomyocytes

(2008) Andrea Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Frank-Starling mechanism in vertebrate cardiac myocytes

(2008) H. A. Shiels et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Troponin and Titin Coordinately Regulate Length-dependent Activation in Skinned Porcine Ventricular Muscle

(2008) Takako Terui et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural Basis for the Regulation of Muscle Contraction by Troponin and Tropomyosin

(2008) Agnieszka Galińska-Rakoczy et al.   JOURNAL OF MOLECULAR BIOLOGY

Restricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisis

(2008) Han-Zhong Feng et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unraveling Molecular Complexity of Phosphorylated Human Cardiac Troponin I by Top Down Electron Capture Dissociation/Electron Transfer Dissociation Mass Spectrometry

(2008) Vlad Zabrouskov et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

(2008) K. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin

(2007) Mohit C. Mathur et al.   BIOPHYSICAL JOURNAL