Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias

(2018) Lukas Clasen et al.   PLoS One

BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes

(2018) Ana De La Mata et al.   STEM CELLS

Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model

(2016) Chun-kai Huang et al.   ACTA PHARMACOLOGICA SINICA

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

(2016) Michael Frisk et al.   CARDIOVASCULAR RESEARCH

Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality

(2016) Simon G Anderson et al.   HEART

Phosphatidylinositol 3-kinase inhibition restores Ca2+release defects and prolongs survival in myotubularin-deficient mice

(2016) Candice Kutchukian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

(2016) Jessica A. Hiemstra et al.   Journal of the American Heart Association

Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules and Ca2+Sparks Produced by Dyssynchronous Heart Failure

(2015) Hui Li et al.   Circulation-Heart Failure

Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current

(2015) Jessica D. Clarke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model

(2015) Margaux A. Horn et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Regulation of Ca2+ transient by PP2A in normal and failing heart

(2015) Ming Lei et al.   Frontiers in Physiology

Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation

(2015) Kristian Eskesen et al.   SpringerPlus

SPEG Interacts with Myotubularin, and Its Deficiency Causes Centronuclear Myopathy with Dilated Cardiomyopathy

(2014) Pankaj B. Agrawal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

(2014) Elisa Giannetta et al.   BMC Medicine

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

(2014) David J. Greensmith et al.   CARDIOVASCULAR RESEARCH

Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1)

(2014) Jessica L. Caldwell et al.   CIRCULATION RESEARCH

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia

(2014) TingTing Hong et al.   NATURE MEDICINE

Three-Dimensional Reconstruction of Cardiac Sarcoplasmic Reticulum Reveals a Continuous Network Linking Transverse-Tubules

(2013) Christian Pinali et al.   CIRCULATION RESEARCH

The myotubularin–amphiphysin 2 complex in membrane tubulation and centronuclear myopathies

(2013) Barbara Royer et al.   EMBO REPORTS

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo

(2012) Dirk Westermann et al.   BASIC RESEARCH IN CARDIOLOGY

Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction

(2012) Eva Wagner et al.   CIRCULATION RESEARCH

Plasticity of Surface Structures and β 2 -Adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure

(2012) Alexander R. Lyon et al.   Circulation-Heart Failure

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+release in a rodent model of heart failure

(2012) Michael Ibrahim et al.   EUROPEAN JOURNAL OF HEART FAILURE

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: Collagen accumulation in the young and loss in the aged

(2012) Margaux A. Horn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transverse tubules are a common feature in large mammalian atrial myocytes including human

(2011) M. A. Richards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway

(2011) Vinh Q. Chau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Strain Transfer in Ventricular Cardiomyocytes to Their Transverse Tubular System Revealed by Scanning Confocal Microscopy

(2011) Thomas G. McNary et al.   BIOPHYSICAL JOURNAL

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

(2011) Alessandra Stangherlin et al.   CIRCULATION RESEARCH

BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes

(2011) Ting-Ting Hong et al.   HEART RHYTHM

Sildenafil Prevents and Reverses Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension

(2011) Yu-Ping Xie et al.   HYPERTENSION

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

(2011) Paul J. M. Wijnker et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure

(2011) Sarah J. Briston et al.   JOURNAL OF PHYSIOLOGY-LONDON

AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve

(2011) Michael G. Katz et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Changes in the Organization of Excitation-Contraction Coupling Structures in Failing Human Heart

(2011) David J. Crossman et al.   PLoS One

The structure and function of cardiac t-tubules in health and disease

(2011) M. Ibrahim et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases

(2011) Lama Al-Qusairi et al.   Skeletal Muscle

Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes

(2010) Liliana R.V. Castro et al.   CIRCULATION RESEARCH

T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

(2010) Sheng Wei et al.   CIRCULATION RESEARCH

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

(2010) Ting-Ting Hong et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Ultrastructural and Functional Remodeling of the Coupling Between Ca 2+ Influx and Sarcoplasmic Reticulum Ca 2+ Release in Right Atrial Myocytes From Experimental Persistent Atrial Fibrillation

(2009) Ilse Lenaerts et al.   CIRCULATION RESEARCH

Characterization of an Extensive Transverse Tubular Network in Sheep Atrial Myocytes and its Depletion in Heart Failure

(2009) Katharine M. Dibb et al.   Circulation-Heart Failure

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase

(2009) L. Al-Qusairi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Myotubularin Function Results in T-Tubule Disorganization in Zebrafish and Human Myotubular Myopathy

(2009) James J. Dowling et al.   PLoS Genetics

Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity

(2008) Zongmin Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differences in intracellular calcium homeostasis between atrial and ventricular myocytes

(2008) A.P. Walden et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY