Role of eIF5A in Mitochondrial Function

Alternative human eIF5A protein isoform plays a critical role in mitochondria

(2021) Karina D. Pereira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development

(2021) Leah R. Padgett et al.   FASEB JOURNAL

Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

(2021) Marc Cougnon et al.   Cell Death & Disease

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

(2021) YongTian Liang et al.   Cell Reports

Dietary spermidine improves cognitive function

(2021) Sabrina Schroeder et al.   Cell Reports

Functional roles of polyamines and their metabolite acrolein in eukaryotic cells

(2021) Kazuei Igarashi et al.   AMINO ACIDS

Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment

(2021) Myung Hee Park et al.   AMINO ACIDS

Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging

(2021) Sebastian J. Hofer et al.   Autophagy

Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis

(2021) Mary Adebayo et al.   FASEB JOURNAL

Hypusinated eIF5A is required for the translation of collagen

(2021) Marina Barba-Aliaga et al.   JOURNAL OF CELL SCIENCE

The Impact of Oxidative Stress on Adipose Tissue Energy Balance

(2020) Peter M. Masschelin et al.   Frontiers in Physiology

The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death‐induced renal injuries in a preclinical porcine kidney transplantation model

(2020) Sebastien Giraud et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inhibition of EIF-5A prevents apoptosis in human cardiomyocytes after malaria infection

(2020) Annette Kaiser et al.   AMINO ACIDS

Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases

(2020) Serena Stanga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

(2020) Shamir Cassim et al.   Cancers

Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes

(2020) Marianna Martella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

(2020) Miled Bourourou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

(2020) Liang Ning et al.   Oncology Letters

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans

(2020) Xin Yang et al.   Aging-US

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

(2020) Dong Ma et al.   PLOS BIOLOGY

Yeast Translation Elongation Factor eIF5A Expression Is Regulated by Nutrient Availability through Different Signalling Pathways

(2020) Marina Barba-Aliaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

(2020) Sonia Coni et al.   Cell Death & Disease

Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder

(2019) Mythily Ganapathi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Indications for a moonlighting function of translation factor aIF5A in the crenarchaeum Sulfolobus solfataricus

(2019) Flavia Bassani et al.   RNA Biology

Transport of Proteins into Mitochondria

(2019) Katja G. Hansen et al.   PROTEIN JOURNAL

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

(2019) Luke S. Tain et al.   AGING CELL

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

(2019) Esther M. Levasseur et al.   Science Signaling

Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection

(2019) Hema Manjunath et al.   Cell Reports

eIF5A is required for autophagy by mediating ATG3 translation

(2018) Michal Lubas et al.   EMBO REPORTS

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

(2018) Jianhua Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing

(2018) Ivaylo P. Ivanov et al.   MOLECULAR CELL

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions

(2018) K. T. Turpaev   BIOCHEMISTRY-MOSCOW

Translation acrobatics: how cancer cells exploit alternate modes of translational initiation

(2018) Ashwin Sriram et al.   EMBO REPORTS

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

(2018) Myung Hee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein

(2018) C Joaquín Cáceres et al.   NUCLEIC ACIDS RESEARCH

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression

(2017) Tiantian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

(2017) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences

(2017) Vicent Pelechano et al.   NUCLEIC ACIDS RESEARCH

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins

(2017) Verónica Muñoz-Soriano et al.   Scientific Reports

Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications

(2016) Silvia Grancara et al.   AMINO ACIDS

Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia

(2016) Mohammad Tariq et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells

(2016) Ting-Ting Cao et al.   CARCINOGENESIS

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

(2016) Iñigo San-Millán et al.   CARCINOGENESIS

Alternative Start Codon Connects eIF5A to Mitochondria

(2016) Karina Danielle Pereira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

(2016) Nicolas Melis et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

(2016) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats

(2016) Jignesh D. Pandya et al.   NEUROBIOLOGY OF AGING

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

(2016) Metin Aksu et al.   Nature Communications

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

Mitochondrial Complex 1 Activity Measured by Spectrophotometry Is Reduced across All Brain Regions in Ageing and More Specifically in Neurodegeneration

(2016) Amelia Kate Pollard et al.   PLoS One

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

(2016) Danuza Rossi et al.   PLoS One

XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A

(2015) T. Miyake et al.   CLINICAL CANCER RESEARCH

The mitochondrial unfolded protein response—synchronizing genomes

(2015) Virginija Jovaisaite et al.   CURRENT OPINION IN CELL BIOLOGY

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential forTrypanosoma bruceiGrowth and for Expression of Polyprolyl-containing Proteins

(2015) Suong Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

(2015) Christian Schmidt et al.   NUCLEIC ACIDS RESEARCH

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

(2014) H. Sievert et al.   Disease Models & Mechanisms

Fertility and Polarized Cell Growth Depends on eIF5A for Translation of Polyproline-Rich Formins in Saccharomyces cerevisiae

(2014) Tianlu Li et al.   GENETICS

Translation Initiation Rate Determines the Impact of Ribosome Stalling on Bacterial Protein Synthesis

(2014) Steven J. Hersch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (−)-Epicatechin in Senile Mice

(2014) Aldo Moreno-Ulloa et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients

(2014) Andrea Bandino et al.   CELLULAR ONCOLOGY

Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function

(2014) Jackelyn M. Kembro et al.   Frontiers in Physiology

eIF5A has a function in the cotranslational translocation of proteins into the ER

(2013) Danuza Rossi et al.   AMINO ACIDS

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy

(2013) Sarah A. Tersey et al.   AMINO ACIDS

N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial–mesenchymal transition in hepatocellular carcinoma cells

(2013) Bin Lou et al.   EXPERIMENTAL CELL RESEARCH

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial proteomics of nasopharyngeal carcinoma metastasis

(2012) Jianping Liu et al.   BMC Medical Genomics

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

(2012) N Minois et al.   Cell Death & Disease

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A

(2011) Mervi T. Hyvönen et al.   AMINO ACIDS

eIF5A isoforms and cancer: two brothers for two functions?

(2011) M. Caraglia et al.   AMINO ACIDS

eIF5A interacts functionally with eEF2

(2011) Camila A. O. Dias et al.   AMINO ACIDS

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

(2011) Kazuhiro Nishimura et al.   AMINO ACIDS

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

(2010) Jia Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Doxorubicin Induces Apoptosis in H9c2 Cardiomyocytes: Role of Overexpressed Eukaryotic Translation Initiation Factor 5A

(2010) Xiao Tan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates

(2010) Sarah-Maria Fendt et al.   BMC Systems Biology

Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway

(2010) Zhong Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional Regulation in Yeast during Diauxic Shift and Stationary Phase

(2010) Luciano Galdieri et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Polyamines: fundamental characters in chemistry and biology

(2009) E. Agostinelli et al.   AMINO ACIDS

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

eIF5A has a function in the elongation step of translation in yeast

(2009) Ana P.B. Gregio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyamine modulon in yeast—Stimulation of COX4 synthesis by spermidine at the level of translation

(2009) Takeshi Uemura et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Glucose regulates transcription in yeast through a network of signaling pathways

(2009) Shadia Zaman et al.   Molecular Systems Biology

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Crystal structure of human eIF5A1: Insight into functional similarity of human eIF5A1 and eIF5A2

(2009) Yufeng Tong et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

(2008) Ting Liu et al.   CIRCULATION RESEARCH

Mitochondrial energetic metabolism: A simplified model of TCA cycle with ATP production

(2008) Christine Nazaret et al.   JOURNAL OF THEORETICAL BIOLOGY

Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart

(2008) Claudia C. Preston et al.   MECHANISMS OF AGEING AND DEVELOPMENT