Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death‐induced renal injuries in a preclinical porcine kidney transplantation model

(2020) Sebastien Giraud et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

(2020) Teresa L. Mastracci et al.   PLoS One

Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

(2020) Miled Bourourou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes

(2019) Shahnawaz Imam et al.   Scientific Reports

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

(2019) Esther M. Levasseur et al.   Science Signaling

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2

(2018) Chiara Ghezzi et al.   DIABETOLOGIA

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

(2018) Myung Hee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein synthesis inhibitor brusatol normalizes high-fat diet–induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

(2018) Kyril Turpaev et al.   FASEB JOURNAL

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

(2016) Shima Nakanishi et al.   AMINO ACIDS

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

(2016) Nicolas Melis et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In silico Design, Synthesis, and Screening of Novel Deoxyhypusine Synthase Inhibitors Targeting HIV-1 Replication

(2014) Marcus Schroeder et al.   ChemMedChem

Genome-Wide Analyses and Functional Classification of Proline Repeat-Rich Proteins: Potential Role of eIF5A in Eukaryotic Evolution

(2014) Ajeet Mandal et al.   PLoS One

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy

(2013) Sarah A. Tersey et al.   AMINO ACIDS

Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

(2013) Stephanie C. Colvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Translational control of eIF5A in various diseases

(2011) Annette Kaiser   AMINO ACIDS

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

eIF5A Promotes Translation Elongation, Polysome Disassembly and Stress Granule Assembly

(2010) Chi Ho Li et al.   PLoS One

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

CFTR mediates cadmium-induced apoptosis through modulation of ROS level in mouse proximal tubule cells

(2008) Sebastien L'hoste et al.   FREE RADICAL BIOLOGY AND MEDICINE