Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development

Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes

(2020) Teresa L. Mastracci et al.   PLoS One

Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder

(2019) Mythily Ganapathi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al

(2019) Hanne V Olesen et al.   Journal of Cystic Fibrosis

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

(2019) Esther M. Levasseur et al.   Science Signaling

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Diagnosis and treatment of pancreatic exocrine insufficiency

(2018) J. Enrique Dominguez-Muñoz   CURRENT OPINION IN GASTROENTEROLOGY

β Cell replacement

(2018) Roberto Castro-Gutierrez et al.   Current Opinion in Endocrinology Diabetes and Obesity

Pluripotent Stem Cell-Derived Pancreatic Progenitors and β-Like Cells for Type 1 Diabetes Treatment

(2018) Rangarajan Sambathkumar et al.   PHYSIOLOGY

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

When β-cells fail: lessons from dedifferentiation

(2016) D. Accili et al.   DIABETES OBESITY & METABOLISM

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

(2016) Aliye Uc et al.   PANCREAS

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Abnormalities of the Exocrine Pancreas in Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   Current Diabetes Reports

Polyamine biosynthesis is critical for growth and differentiation of the pancreas

(2015) Teresa L. Mastracci et al.   Scientific Reports

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet  -Cells via Activation of the Mammalian Target of Rapamycin Pathway

(2014) M. Hatanaka et al.   DIABETES

The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae

(2014) Whitney R. Smith-Kinnaman et al.   Molecular BioSystems

American College of Gastroenterology Guideline: Management of Acute Pancreatitis

(2013) Scott Tenner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis

(2013) Stephanie L M Das et al.   GUT

Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

(2013) Stephanie C. Colvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas

(2013) Teresa L. Mastracci et al.   PLoS Genetics

Characterization of a novel polyclonal anti-hypusine antibody

(2013) Yurika Nishiki et al.   SpringerPlus

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

Exocrine ontogenies: On the development of pancreatic acinar, ductal and centroacinar cells

(2012) Megan H. Cleveland et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

(2011) Kazuhiro Nishimura et al.   AMINO ACIDS

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

(2011) Andrew T. Templin et al.   CELL CYCLE

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycemia and Diabetes Mellitus in Children with Pancreatitis

(2010) Vandana S. Raman et al.   JOURNAL OF PEDIATRICS

Highly Reproducible Label Free Quantitative Proteomic Analysis of RNA Polymerase Complexes

(2010) Amber L. Mosley et al.   MOLECULAR & CELLULAR PROTEOMICS

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE