Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

(2018) Chad R. Schultz et al.   BIOCHEMICAL JOURNAL

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences

(2017) Vicent Pelechano et al.   NUCLEIC ACIDS RESEARCH

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

(2016) Shima Nakanishi et al.   AMINO ACIDS

Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia

(2016) Mohammad Tariq et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity

(2016) Asad Ali Shah et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells

(2016) Ting-Ting Cao et al.   CARCINOGENESIS

Repositioning the Old Fungicide Ciclopirox for New Medical Uses

(2016) Tao Shen et al.   CURRENT PHARMACEUTICAL DESIGN

The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma

(2016) T Muramatsu et al.   ONCOGENE

Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma

(2016) Shahram Khosravi et al.   Oncology Letters

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

(2016) Danuza Rossi et al.   PLoS One

Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport

(2015) Mervi T. Hyvönen et al.   ACS Chemical Biology

The translation factor eIF5A and human cancer

(2015) Michael B. Mathews et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential forTrypanosoma bruceiGrowth and for Expression of Polyprolyl-containing Proteins

(2015) Suong Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Relevance and Therapeutic Potential of the Hypusine Modification System

(2015) Nora Pällmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

(2015) Christian Schmidt et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination

(2015) Zhenggang Han et al.   STRUCTURE

Overexpression of Eukaryotic Translation Initiation Factor 5A2 (EIF5A2) Correlates with Cell Aggressiveness and Poor Survival in Gastric Cancer

(2015) Qing-Bin Meng et al.   PLoS One

The hypusine-containing translation factor eIF5A

(2014) Thomas E. Dever et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line

(2014) Oedem Jr et al.   CURRENT PHARMACEUTICAL DESIGN

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

(2014) H. Sievert et al.   Disease Models & Mechanisms

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Genome-Wide Analyses and Functional Classification of Proline Repeat-Rich Proteins: Potential Role of eIF5A in Eukaryotic Evolution

(2014) Ajeet Mandal et al.   PLoS One

Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

(2014) A. G. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients

(2014) Andrea Bandino et al.   CELLULAR ONCOLOGY

eIF5A has a function in the cotranslational translocation of proteins into the ER

(2013) Danuza Rossi et al.   AMINO ACIDS

Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy

(2013) Sarah A. Tersey et al.   AMINO ACIDS

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

(2013) Elisabeth Mémin et al.   CANCER RESEARCH

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl

(2013) D. Mokhtari et al.   DIABETOLOGIA

Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

(2013) Stephanie C. Colvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

(2012) Muhammad ISHFAQ et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

(2012) Muhammad Ishfaq et al.   FEBS LETTERS

Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias

(2012) Patrick Ziegler et al.   INVESTIGATIONAL NEW DRUGS

Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

(2012) Yurika Nishiki et al.   MOLECULAR ENDOCRINOLOGY

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

eIF5A isoforms and cancer: two brothers for two functions?

(2011) M. Caraglia et al.   AMINO ACIDS

eIF5A interacts functionally with eEF2

(2011) Camila A. O. Dias et al.   AMINO ACIDS

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

(2011) Kazuhiro Nishimura et al.   AMINO ACIDS

Translational control of eIF5A in various diseases

(2011) Annette Kaiser   AMINO ACIDS

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling

(2011) Andrew T. Templin et al.   CELL CYCLE

Unique modifications of translation elongation factors

(2011) Eva Greganova et al.   FEBS Journal

Post-translational Modification by β-Lysylation Is Required for Activity of Escherichia coli Elongation Factor P (EF-P)

(2011) Jong-Hwan Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of maize eukaryotic translation initiation factor on Ser2 by catalytic subunit CK2

(2011) Elżbieta Lewandowska-Gnatowska et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae

(2011) A. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting an old acquaintance: role for eIF5A in diabetes

(2010) Joachim Hauber   JOURNAL OF CLINICAL INVESTIGATION

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

Thermal killing of human colon cancer cells is associated with the loss of eukaryotic initiation factor 5A

(2009) Alexander Gosslau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

(2009) Mainul Hoque et al.   Retrovirology

Modulation of the Rate of Peptidyl Transfer on the Ribosome by the Nature of Substrates

(2008) Ingo Wohlgemuth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slow peptide bond formation by proline and other N-alkylamino acids in translation

(2008) M. Y. Pavlov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA