Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?

(2016) James C. Sorensen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mitochondrial Function, Biology, and Role in Disease

(2016) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Mechanisms of Cardiac Regeneration

(2016) Aysu Uygur et al.   DEVELOPMENTAL CELL

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

(2016) Aleksandr Stotland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Staying young at heart: autophagy and adaptation to cardiac aging

(2016) Leonardo J. Leon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Caloric restriction and exercise “mimetics’’: Ready for prime time?

(2016) Christoph Handschin   PHARMACOLOGICAL RESEARCH

Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure

(2015) Knut H. Lauritzen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

(2015) Aleksandr E. Vendrov et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

Morphometric examination of mitochondrial ultrastructure in aging cardiomyocytes

(2015) Ch. M. El’darov et al.   BIOCHEMISTRY-MOSCOW

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

Muscle wasting in cancer

(2015) Josep M. Argilés et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mitochondrial plasticity in cancer-related muscle wasting

(2015) Rui Vitorino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Intrinsic and extrinsic mechanisms regulating satellite cell function

(2015) N. A. Dumont et al.   DEVELOPMENT

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

(2015) Sang-Bing Ong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis

(2015) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial DNA maintenance: an appraisal

(2015) Alexander T. Akhmedov et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle

(2015) Elena Barbieri et al.   Oxidative Medicine and Cellular Longevity

Altered FoF1 ATP synthase and susceptibility to mitochondrial permeability transition pore during ischaemia and reperfusion in aging cardiomyocytes

(2015) Celia Fernandez-Sanz et al.   THROMBOSIS AND HAEMOSTASIS

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

(2015) Ying Wang et al.   Nature Communications

Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015

(2015) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

The altered fate of aging satellite cells is determined by signaling and epigenetic changes

(2015) Maura H. Parker   Frontiers in Genetics

Truncated splice variant PGC-1α4 is not associated with exercise-induced human muscle hypertrophy

(2014) T. R. Lundberg et al.   Acta Physiologica

Three-dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization

(2014) R. Dahl et al.   Acta Physiologica

Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: influence of cardiac pathologies

(2014) John M. Hollander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity

(2014) Francesca Lo Verso et al.   Autophagy

Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?

(2014) Robert Kob et al.   BIOGERONTOLOGY

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy

(2014) Moshi Song et al.   CIRCULATION RESEARCH

Metabolic Dysfunction Consistent With Premature Aging Results From Deletion of Pim Kinases

(2014) Shabana Din et al.   CIRCULATION RESEARCH

Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats

(2014) Lin Zhao et al.   EXPERIMENTAL GERONTOLOGY

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

Proteome Analysis of Subsarcolemmal Cardiomyocyte Mitochondria: A Comparison of Different Analytical Platforms

(2014) Francesco Giorgianni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

(2014) Nelson Escobales et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (−)-Epicatechin in Senile Mice

(2014) Aldo Moreno-Ulloa et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inhibition of Delta-6 Desaturase Reverses Cardiolipin Remodeling and Prevents Contractile Dysfunction in the Aged Mouse Heart Without Altering Mitochondrial Respiratory Function

(2014) Christopher M. Mulligan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Strategies for treating mitochondrial disorders: An update

(2014) Mauro Scarpelli et al.   MOLECULAR GENETICS AND METABOLISM

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

The Order of Exercise during Concurrent Training for Rehabilitation Does Not Alter Acute Genetic Expression, Mitochondrial Enzyme Activity or Improvements in Muscle Function

(2014) Lauren G. MacNeil et al.   PLoS One

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

(2014) Russell T. Hepple   Frontiers in Aging Neuroscience

Osteosarcopenic obesity: the role of bone, muscle, and fat on health

(2014) Michael J. Ormsbee et al.   Journal of Cachexia Sarcopenia and Muscle

Strength and Endurance Training Prescription in Healthy and Frail Elderly

(2014) Eduardo Cadore   Aging and Disease

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

(2013) Michael P. Siegel et al.   AGING CELL

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria

(2013) Takhar Kasumov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation

(2013) Boa Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Age-dependent effects of high fat-diet on murine left ventricles: role of palmitate

(2013) Anne-Cathleen Aurich et al.   BASIC RESEARCH IN CARDIOLOGY

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes

(2013) Kinyui Alice Lo et al.   BIOSCIENCE REPORTS

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ageing-induced decrease in cardiac mitochondrial function in healthy rats

(2013) Oana M. Duicu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase

(2013) Sadia Mohsin et al.   CIRCULATION RESEARCH

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals

(2013) Anna-Maria Joseph et al.   EXPERIMENTAL GERONTOLOGY

Characteristics of cardiac aging in C57BL/6 mice

(2013) Zhao Cheng et al.   EXPERIMENTAL GERONTOLOGY

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials

(2013) Emanuele Marzetti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant

(2013) Erin E. Talbert et al.   JOURNAL OF APPLIED PHYSIOLOGY

GSK-3α is a central regulator of age-related pathologies in mice

(2013) Jibin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

The Influence of Shc Proteins on Life Span in Mice

(2013) Jon J. Ramsey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse

(2013) Sobia Iqbal et al.   MUSCLE & NERVE

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

(2013) Anna-Maria Joseph et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Skeletal muscle aging and the mitochondrion

(2013) Matthew L. Johnson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Mitochondria and endocrine function of adipose tissue

(2012) Gema Medina-Gómez   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Pharmacological and nutritional agents promoting browning of white adipose tissue

(2012) M. Luisa Bonet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial dynamics in heart disease

(2012) Gerald W. Dorn   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

(2012) Debapriya Dutta et al.   CIRCULATION RESEARCH

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

(2012) Pei Wang et al.   DIABETES

Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction

(2012) Nis Stride et al.   EUROPEAN JOURNAL OF HEART FAILURE

Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue

(2012) Bernd Niemann et al.   EXPERIMENTAL GERONTOLOGY

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults

(2012) Paul M. Coen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart

(2012) T. S. Lancaster et al.   PHYSIOLOGICAL GENOMICS

Skeletal Muscle Apoptotic Signaling Predicts Thigh Muscle Volume and Gait Speed in Community-Dwelling Older Persons: An Exploratory Study

(2012) Emanuele Marzetti et al.   PLoS One

Mitochondrial Function in Permeabilized Cardiomyocytes Is Largely Preserved in the Senescent Rat Myocardium

(2012) Martin Picard et al.   PLoS One

Skeletal muscle transcriptional coactivator PGC-1  mediates mitochondrial, but not metabolic, changes during calorie restriction

(2012) L. W. S. Finley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

(2012) Kunihiro Sakuma et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency

(2012) Cloé M. Julienne et al.   Journal of Cachexia Sarcopenia and Muscle

Brown adipose tissue

(2012) Kristy Townsend et al.   Adipocyte

Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A

(2011) L. LIU et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

The p66Shcknockout mice are short lived under natural condition

(2011) Marco Giorgio et al.   AGING CELL

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy

(2011) Andrew J. Boyle et al.   EXPERIMENTAL GERONTOLOGY

Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys

(2011) Susan H. McKiernan et al.   EXPERIMENTAL GERONTOLOGY

Obesity Induces Signs of Premature Cardiac Aging in Younger Patients

(2011) Bernd Niemann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults

(2011) Carol Ewing Garber et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epidemiology of sarcopenia in community living older adults: what role does lifestyle play?

(2011) David Scott et al.   Journal of Cachexia Sarcopenia and Muscle

Inverse association between adiposity and telomere length: The fels longitudinal study

(2010) Miryoung Lee et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Mitochondria in Postconditioning

(2010) Kerstin Boengler et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

(2010) Raquel S. Carreira et al.   Autophagy

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations

(2010) Jeffrey S. Monette et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy

(2010) James Rochon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2010) Karsten Lenk et al.   Journal of Cachexia Sarcopenia and Muscle

Perspective: Does brown fat protect against diseases of aging?

(2009) Mark P. Mattson   AGEING RESEARCH REVIEWS

Diminished contraction-induced intracellular signaling towards mitochondrial biogenesis in aged skeletal muscle

(2009) Vladimir Ljubicic et al.   AGING CELL

Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon,Columba livia

(2009) Adrian J. Lambert et al.   AGING CELL

eNOS uncoupling and endothelial dysfunction in aged vessels

(2009) Yang-Ming Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function

(2009) Andrew C. Betik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) M. A. Tarnopolsky   Applied Physiology Nutrition and Metabolism

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

(2009) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Lipid homeostasis, lipotoxicity and the metabolic syndrome

(2009) Roger H. Unger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Suppression of Phosphoinositide 3-Kinase Prevents Cardiac Aging in Mice

(2009) Yasutaka Inuzuka et al.   CIRCULATION

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Modulation of Skeletal Muscle Insulin Signaling With Chronic Caloric Restriction in Cynomolgus Monkeys

(2009) Z. Q. Wang et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Effect of Aging on Human Skeletal Muscle Mitochondrial and Intramyocellular Lipid Ultrastructure

(2009) J. D. Crane et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: Effects of aging and lifelong calorie restriction

(2009) Tim Hofer et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle

(2009) Vladimir Ljubicic et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exercise and Physical Activity for Older Adults

(2009) Wojtek J. Chodzko-Zajko et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle

(2009) Kathleen O'Connell et al.   PROTEOMICS

Mitochondrial protein phosphorylation: instigator or target of lipotoxicity?

(2009) Wolfgang F. Graier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Morphometric Changes Induced by Amino Acid Supplementation in Skeletal and Cardiac Muscles of Old Mice

(2008) Giovanni Corsetti et al.   AMERICAN JOURNAL OF CARDIOLOGY

Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity

(2008) Dustin Slivka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Proteomic profiling of aging in the mouse heart: Altered expression of mitochondrial proteins

(2008) Bulbul Chakravarti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype

(2008) Tina Wenz et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

(2008) G PETROSILLO et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts

(2008) Manuel Mayr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Combined Metabolomic and Proteomic Analysis of Human Atrial Fibrillation

(2008) Manuel Mayr et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

(2008) Emanuele Marzetti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart

(2008) Claudia C. Preston et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Caloric Restriction Retards the Age-Related Decline in Mitochondrial Function of Brown Adipose Tissue

(2008) Adamo Valle et al.   REJUVENATION RESEARCH

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle

(2007) Béatrice Chabi et al.   AGING CELL

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

(2007) Emanuele Marzetti et al.   FREE RADICAL BIOLOGY AND MEDICINE