Regulation of B Cell Responses in SLE by Three Classes of Interferons

Partial Protection From Lupus-Like Disease by B-Cell Specific Type I Interferon Receptor Deficiency

(2021) Emma J. Keller et al.   Frontiers in Immunology

Interferon α Enhances B Cell Activation Associated With FOXM1 Induction: Potential Novel Therapeutic Strategy for Targeting the Plasmablasts of Systemic Lupus Erythematosus

(2021) Kanae Akita et al.   Frontiers in Immunology

Interferon lambda in inflammation and autoimmune rheumatic diseases

(2021) Rishi R. Goel et al.   Nature Reviews Rheumatology

Type I Interferonopathies in Children: An Overview

(2021) Debora M. d'Angelo et al.   Frontiers in Pediatrics

Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus

(2021) Jodi L. Karnell et al.   Science Translational Medicine

Age-Associated B Cells

(2020) Michael P. Cancro   Annual Review of Immunology

Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity

(2020) Sathi Babu Chodisetti et al.   JOURNAL OF IMMUNOLOGY

Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

(2020) Rishi R. Goel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

(2020) Chetna Soni et al.   IMMUNITY

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development

(2020) Sathi Babu Chodisetti et al.   JOURNAL OF IMMUNOLOGY

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

(2020) Sladjana Skopelja-Gardner et al.   Scientific Reports

B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria

(2020) William O. Hahn et al.   Virulence

Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

(2020) Yessia Hidalgo et al.   Frontiers in Immunology

TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner

(2020) Sathi Babu Chodisetti et al.   Frontiers in Immunology

Characterization of autoantibodies and cytokines related to cutaneous lupus erythematosus

(2020) Feng-qiu Hu et al.   LUPUS

Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway

(2020) Mohammedyaseen Syedbasha et al.   Cell Reports

Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways

(2020) Candice Mazewski et al.   Frontiers in Immunology

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus

(2019) Tao Wang et al.   Biomed Research International

IFNγ induces epigenetic programming of human T-bethi B cells and promotesTLR7/8 and IL-21 induced differentiation

(2019) Esther Zumaquero et al.   eLife

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

(2019) Jason B. Wong et al.   Nature Communications

IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis

(2019) Mayada Metwally et al.   Scientific Reports

Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production

(2019) Satoko Hara et al.   Frontiers in Immunology

Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both?

(2019) Gregg J Silverman et al.   CURRENT OPINION IN IMMUNOLOGY

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

IFN-γ stimulates CpG-induced IL-10 production in B cells via p38 and JNK signalling pathways

(2018) Maya Imbrechts et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR7-Mediated Lupus Nephritis Is Independent of Type I IFN Signaling

(2018) Sonya J. Wolf et al.   JOURNAL OF IMMUNOLOGY

B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

(2018) Phillip P. Domeier et al.   Cell Reports

Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells

(2018) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Comprehensive network map of interferon gamma signaling

(2018) Mohd Younis Bhat et al.   Journal of Cell Communication and Signaling

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

(2018) Gustavo P. Amarante-Mendes et al.   Frontiers in Immunology

Type III Interferons in Systemic Lupus Erythematosus

(2017) Luis M. Amezcua-Guerra et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

The molecular basis for differential type I interferon signaling

(2017) Gideon Schreiber   JOURNAL OF BIOLOGICAL CHEMISTRY

Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers

(2017) Stephanie L. Schell et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells

(2017) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Interferon Lambda Genetics and Biology in Regulation of Viral Control

(2017) Emily A. Hemann et al.   Frontiers in Immunology

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome

(2016) E. Apostolou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

(2016) Madhvi Menon et al.   IMMUNITY

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

(2016) Phillip P. Domeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-targeted therapy in systemic lupus erythematosus: Is this an alternative to targeting B and T cells?

(2016) K C Kalunian   LUPUS

Type I interferonopathies in pediatric rheumatology

(2016) Stefano Volpi et al.   Pediatric Rheumatology

Phenotypic and functional alterations of pDCs in lupus-prone mice

(2016) Zhenyuan Zhou et al.   Scientific Reports

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus

(2015) Hao Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels

(2015) Ying-Yu Wu et al.   JOURNAL OF IMMUNOLOGY

IFN-  is able to augment TLR-mediated activation and subsequent function of primary human B cells

(2015) R. A. de Groen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation

(2015) Elizabeth E. Waffarn et al.   Nature Communications

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

(2014) Masahide Funabiki et al.   IMMUNITY

Environmental Factors, Toxicants and Systemic Lupus Erythematosus

(2014) Anselm Mak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

(2014) S. W. Jackson et al.   JOURNAL OF IMMUNOLOGY

B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

(2014) Chetna Soni et al.   JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Dysregulated Cytokine Production by Dendritic Cells Modulates B Cell Responses in the NZM2410 Mouse Model of Lupus

(2014) Allison Sang et al.   PLoS One

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

(2013) Natalia V. Giltiay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum IFN-λ1 is abnormally elevated in rheumatoid arthritis patients

(2012) Qian Wu et al.   AUTOIMMUNITY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis

(2012) Fang Wang et al.   ARTHRITIS RESEARCH & THERAPY

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Tolerogenic function of Blimp-1 in dendritic cells

(2011) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells

(2011) N. A. Carter et al.   JOURNAL OF IMMUNOLOGY

Interferon-Alpha Triggers B Cell Effector 1 (Be1) Commitment

(2011) Marie-Ghislaine de Goër de Herve et al.   PLoS One

A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells

(2011) K. Miles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity

(2011) Qian Wu et al.   ARTHRITIS RESEARCH & THERAPY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice

(2010) Thomas Tiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95

(2008) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

(2008) B. Mietzner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens