Article
Biochemistry & Molecular Biology
Tao Ming Sim, Siying Jane Ong, Anselm Mak, Sen Hee Tay
Summary: This review discusses the bench to bedside translation of the type I IFN pathway and explores some unresolved issues when selecting SLE patients for treatment with biologics targeting type I IFNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi, Ninghan Feng
Summary: The microbiome alterations in the gut and oral cavity are associated with the development of systemic lupus erythematosus (SLE). Research on 35 SLE patients revealed reduced bacterial richness and diversity in feces, and increased bacterial diversity in saliva. These findings suggest that different body niches in SLE patients have distinct bacterial profiles that may play a role in the disease development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julius Lindblom, Daniel Toro-Dominguez, Elena Carnero-Montoro, Lorenzo Beretta, Maria Orietta Borghi, Jessica Castillo, Yvonne Enman, Chandra Mohan, Marta E. Alarcon-Riquelme, Guillermo Barturen, Ioannis Parodis
Summary: This study aimed to investigate the transcriptome, eQTLs, and serological markers in SLE patients compared to healthy controls. The analysis revealed the significance of interferon signaling pathways and downregulation of lymphocyte signaling cluster in renal activity. Upregulation of interferon-related genes indicated hematological activity and vasculitis. Modulation of interferon, STAT1, PLK1, B and plasma cell signatures showed promise as viable approaches to treat SLE.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Multidisciplinary Sciences
Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This meta-analysis revealed that the circulating level of interleukin-18 is significantly higher in systemic lupus erythematosus (SLE) patients compared to healthy controls. Patients with higher SLEDAI scores, Asian, White, Arab, or mixed ethnicity tend to have elevated levels of IL-18, indicating the potential role of IL-18 in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Biochemistry & Molecular Biology
Masahiro Nakano, Mineto Ota, Yusuke Takeshima, Yukiko Iwasaki, Hiroaki Hatano, Yasuo Nagafuchi, Takahiro Itamiya, Junko Maeda, Ryochi Yoshida, Saeko Yamada, Aya Nishiwaki, Haruka Takahashi, Hideyuki Takahashi, Yuko Akutsu, Takeshi Kusuda, Hiroyuki Suetsugu, Lu Liu, Kwangwoo Kim, Xianyong Yin, So-Young Bang, Yong Cui, Hye-Soon Lee, Hirofumi Shoda, Xuejun Zhang, Sang-Cheol Bae, Chikashi Terao, Kazuhiko Yamamoto, Tomohisa Okamura, Kazuyoshi Ishigaki, Keishi Fujio
Summary: This study conducted a large-scale transcriptome analysis to understand the dysregulated gene expression patterns in systemic lupus erythematosus (SLE). The researchers identified cell-type-specific transcriptomic signatures associated with disease establishment and exacerbation. The study suggested the clinical value of disease-activity signatures in predicting organ involvement and therapeutic responses.
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Inglese, Ilse M. J. Kant, Rory C. Monahan, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Mark A. van Buchem, Cesar Magro-Checa, Itamar Ronen, Jeroen de Bresser
Summary: This study investigated the structural brain correlates of neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) and found that different phenotypes of NPSLE were associated with distinct patterns of underlying structural brain MRI changes. The inflammatory phenotype of NPSLE showed the most pronounced brain volume changes, which could help facilitate diagnosis in SLE patients with neuropsychiatric symptoms.
EUROPEAN RADIOLOGY
(2021)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Renata Baronaite Hansen, Julia F. Simard, Mikkel Faurschou, Soren Jacobsen
Summary: This study aimed to assess the prevalence of pre-existing comorbidities among patients diagnosed with systemic lupus erythematosus (SLE) in Denmark. It found that SLE patients had significantly higher rates of neuropsychiatric, cardiovascular, and venous thromboembolic diseases compared to the general population 10 years before the SLE diagnosis. The study highlights the importance of early clinical vigilance towards comorbidities in individuals with SLE.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Immunology
Weijie Wang, Yongsheng Fan, Xinchang Wang
Summary: This review discusses the dual role of Lactobacillus in systemic lupus erythematosus (SLE), as it can both affect the development of SLE and have therapeutic and anti-inflammatory effects. The involvement of Lactobacillus in SLE sheds light on the understanding of its development and provides evidence for the development of microbiota-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Yussef Esparza Guerrero, Maria Luisa Vazquez Villegas, Cesar Arturo Nava Valdivia, Juan Manuel Ponce Guarneros, Edsaul Emilio Perez Guerrero, Eli Efrain Gomez Ramirez, Melissa Ramirez Villafana, Betsabe Contreras Haro, Alejandra Martinez Hernandez, Ernesto German Cardona Munoz, Ismael Nuno Arana, Sergio Gabriel Gallardo Moya, Alfredo Celis, Laura Gonzalez Lopez, Jorge Ivan Gamez Nava, Ana Miriam Saldana Cruz
Summary: STAT4 plays an important role in disease activity in SLE patients by activating genes associated with TH1 and Th17 lymphocyte production, particularly IFN-gamma and IL-17A. Variants in STAT4 genes have a major impact on autoimmunity generation, but few studies have evaluated their impact on proinflammatory cytokines.
Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
