Interferon lambda in inflammation and autoimmune rheumatic diseases

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

(2020) Rishi R. Goel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

(2020) Deanna M. Santer et al.   PLoS Pathogens

IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells

(2020) Mohamed Benhammadi et al.   JOURNAL OF IMMUNOLOGY

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

(2020) Jack Major et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis

(2020) Yueqi Chen et al.   Cell Death & Disease

Characterization of autoantibodies and cytokines related to cutaneous lupus erythematosus

(2020) Feng-qiu Hu et al.   LUPUS

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis

(2020) Andrea Rubbert-Roth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway

(2020) Mohammedyaseen Syedbasha et al.   Cell Reports

Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus

(2020) Kerry A Casey et al.   Arthritis & Rheumatology

Study of Tofacitinib In Refractory Dermatomyositis (STIR): An open label pilot study of 10 patients

(2020) Julie J. Paik et al.   Arthritis & Rheumatology

Interferon lambda protects the female reproductive tract against Zika virus infection

(2019) Elizabeth A. Caine et al.   Nature Communications

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

(2019) Liang Ye et al.   NATURE IMMUNOLOGY

Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus

(2019) Richard Furie et al.   JOURNAL OF CLINICAL INVESTIGATION

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study

(2019) Josef S Smolen et al.   LANCET

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

(2019) Emily A. Hemann et al.   NATURE IMMUNOLOGY

New therapies for systemic lupus erythematosus — past imperfect, future tense

(2019) Grainne Murphy et al.   Nature Reviews Rheumatology

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

(2019) Nikaïa Smith et al.   Science Advances

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Cutaneous lupus erythematosus: new insights into pathogenesis and therapeutic strategies

(2019) Joerg Wenzel   Nature Reviews Rheumatology

IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis

(2019) Mayada Metwally et al.   Scientific Reports

Macrophage Coordination of the Interferon Lambda Immune Response

(2019) Scott A. Read et al.   Frontiers in Immunology

IFN-α kinoid in systemic lupus erythematosus: results from a phase IIb, randomised, placebo-controlled study

(2019) Frederic A Houssiau et al.   ANNALS OF THE RHEUMATIC DISEASES

Deadliest catch

(2019) Rishi R. Goel et al.   CURRENT OPINION IN RHEUMATOLOGY

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs

(2018) Massimo Gadina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial

(2018) Mark C Genovese et al.   LANCET

Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Gerd R Burmester et al.   LANCET

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Daniel J Wallace et al.   LANCET

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

(2018) Jonas Klinkhammer et al.   eLife

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

(2018) Kalliopi Pervolaraki et al.   PLoS Pathogens

Type I Interferons in Autoimmune Disease

(2018) Mary K. Crow et al.   Annual Review of Pathology-Mechanisms of Disease

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease

(2017) Mircea T. Chiriac et al.   GASTROENTEROLOGY

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

Type III Interferons in Systemic Lupus Erythematosus

(2017) Luis M. Amezcua-Guerra et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expressionin vivo

(2017) Tanja Blumer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of type III interferons to antiviral immunity: location, location, location

(2017) Sergei V. Kotenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of NK Cells in IL-28B–Mediated Immunity against Influenza Virus Infection

(2017) Yanshi Wang et al.   JOURNAL OF IMMUNOLOGY

Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus

(2017) Benedikt Scholtissek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation

(2017) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

(2017) Megan T. Baldridge et al.   JOURNAL OF VIROLOGY

Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial

(2017) Roy Fleischmann et al.   LANCET

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

(2017) Peter C. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elevated Serum Levels of Interleukin-29 Are Associated with Disease Activity in Rheumatoid Arthritis Patients with Anti-Cyclic Citrullinated Peptide Antibodies

(2017) Qiong-jie Chang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Baricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease-Modifying Antirheumatic Drug Treatment

(2017) Roy Fleischmann et al.   Arthritis & Rheumatology

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

(2017) Ivan Zanoni et al.   Frontiers in Immunology

Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells

(2017) Tharini A. Selvakumar et al.   Frontiers in Immunology

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study

(2016) Munther Khamashta et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome

(2016) E. Apostolou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Synergistic production of TNFα and IFNα by human pDCs incubated with IFNλ3 and IL-3

(2016) Giulia Finotti et al.   CYTOKINE

Why, why, why de-lupus (does so badly in clinical trials)

(2016) David A Isenberg et al.   Expert Review of Clinical Immunology

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway

(2016) Aoife Kelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Baricitinib in Patients with Refractory Rheumatoid Arthritis

(2016) Mark C. Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

(2016) Julie Ducreux et al.   RHEUMATOLOGY

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

(2016) Jian-Da Lin et al.   PLoS Pathogens

Ocular Fluid Analysis in Children Reveals Interleukin-29/Interferon-λ1 as a Biomarker for Juvenile Idiopathic Arthritis-Associated Uveitis

(2016) Anne-Mieke J. W. Haasnoot et al.   Arthritis & Rheumatology

Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction

(2016) Yasuko Furumoto et al.   Arthritis & Rheumatology

A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C

(2016) Robert Flisiak et al.   PLoS One

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferons and systemic sclerosis: correlation between interferon gamma and interferon-lambda 1 (IL-29)

(2015) Andréa Tavares Dantas et al.   AUTOIMMUNITY

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism

(2015) Adewonuola A. Alase et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

(2015) Xiang Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IFN-  is able to augment TLR-mediated activation and subsequent function of primary human B cells

(2015) R. A. de Groen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endogenously produced TNF-α contributes to the expression of CXCL10/IP-10 in IFN-λ3-activated plasmacytoid dendritic cells

(2015) Giulia Finotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

IFN-λ-mediated IL-12 production in macrophages induces IFN-γ production in human NK cells

(2014) Rik A. de Groen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFNL cytokines do not modulate human or murine NK cell functions

(2014) Maria H. Morrison et al.   HUMAN IMMUNOLOGY

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with theIFN-λ3genotype and with nonresponsiveness to IFN-α therapies

(2014) Francois H.T. Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection

(2014) Andrew J. Muir et al.   JOURNAL OF HEPATOLOGY

An Important Role for Type III Interferon (IFN- /IL-28) in TLR-Induced Antiviral Activity

(2014) N. Ank et al.   JOURNAL OF IMMUNOLOGY

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

IFN-  Exerts Opposing Effects on T Cell Responses Depending on the Chronicity of the Virus Infection

(2014) I. Misumi et al.   JOURNAL OF IMMUNOLOGY

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

(2014) Avram Goldberg et al.   ARTHRITIS RESEARCH & THERAPY

IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza

(2014) Adrian Egli et al.   PLoS Pathogens

The type I IFN signature as a biomarker of preclinical rheumatoid arthritis

(2013) Joyce Lübbers et al.   ANNALS OF THE RHEUMATIC DISEASES

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

(2013) Brandon W Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

(2013) Christoph Burkart et al.   EMBO Molecular Medicine

Association analyses identifying two common susceptibility loci shared by psoriasis and systemic lupus erythematosus in the Chinese Han population

(2013) Yang Li et al.   JOURNAL OF MEDICAL GENETICS

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Suppression of soluble T cell-associated proteins by an anti-interferon-  monoclonal antibody in adult patients with dermatomyositis or polymyositis

(2013) X. Guo et al.   RHEUMATOLOGY

IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis

(2013) K. Wolk et al.   Science Translational Medicine

IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients

(2013) Lingxiao Xu et al.   ARTHRITIS RESEARCH & THERAPY

Epicutaneous Application of Toll-like Receptor 7 Agonists Leads to Systemic Autoimmunity in Wild-Type Mice: A New Model of Systemic Lupus Erythematosus

(2013) Maki Yokogawa et al.   Arthritis & Rheumatology

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

Serum IFN-λ1 is abnormally elevated in rheumatoid arthritis patients

(2012) Qian Wu et al.   AUTOIMMUNITY

Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells

(2012) Z. Yin et al.   JOURNAL OF IMMUNOLOGY

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway

(2012) Man-Qing Liu et al.   PLoS One

Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis

(2012) Fang Wang et al.   ARTHRITIS RESEARCH & THERAPY

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

Profiling the expression of interleukin (IL)-28 and IL-28 receptor α in systemic lupus erythematosus patients

(2011) Shih-Chang Lin et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity

(2011) Qian Wu et al.   ARTHRITIS RESEARCH & THERAPY

IL-29 and IFN  differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFN  receptor expression

(2010) B.-S. Liu et al.   BLOOD

Evidence for a Pathophysiological Role of Keratinocyte-Derived Type III Interferon (IFNλ) in Cutaneous Lupus Erythematosus

(2010) Sabine Zahn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Comparative Analysis of the Lambda-Interferons IL-28A and IL-29 regarding Their Transcriptome and Their Antiviral Properties against Hepatitis C Virus

(2010) Julia Diegelmann et al.   PLoS One

Lambda Interferon Inhibits Human Immunodeficiency Virus Type 1 Infection of Macrophages

(2009) W. Hou et al.   JOURNAL OF VIROLOGY

Human interferon-λ3 is a potent member of the type III interferon family

(2008) C Dellgren et al.   GENES AND IMMUNITY

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens