Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

(2018) Phillip P. Domeier et al.   Cell Reports

IL-6: a cytokine at the crossroads of autoimmunity

(2018) Britta E Jones et al.   CURRENT OPINION IN IMMUNOLOGY

Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus

(2018) Kei Sakata et al.   Frontiers in Immunology

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

(2017) Kira Rubtsova et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

(2017) Tanvi Arkatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen Receptor α Signaling Exacerbates Immune-Mediated Nephropathies through Alteration of Metabolic Activity

(2017) Chelsea Corradetti et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells

(2017) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells

(2017) Amy N. Suthers et al.   Frontiers in Immunology

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

(2016) Phillip P. Domeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

(2016) Xiaofeng Liao et al.   MEDIATORS OF INFLAMMATION

Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development

(2016) Nilushi S. De Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity

(2015) Chetna Soni et al.   JOURNAL OF AUTOIMMUNITY

The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor α (TNF-α) Production

(2015) Guiliang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

(2015) Chandra Mohan et al.   Nature Reviews Nephrology

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

(2015) Sebastian Wienerroither et al.   Cell Reports

Blockade of Interferon-γ Normalizes Interferon-Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus

(2015) Andrew A. Welcher et al.   Arthritis & Rheumatology

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

(2014) Sinisa Savic et al.   JOURNAL OF AUTOIMMUNITY

Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits

(2014) Nicole Heise et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Excessive Production of IFN-  in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B

(2014) M. Harigai et al.   JOURNAL OF IMMUNOLOGY

Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

(2014) S. W. Jackson et al.   JOURNAL OF IMMUNOLOGY

B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

(2014) Chetna Soni et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment

(2014) Teja Celhar et al.   Frontiers in Pharmacology

Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus

(2013) Lino L. Teichmann et al.   IMMUNITY

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

(2013) Yu Qiao et al.   IMMUNITY

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

(2013) Z. Hua et al.   JOURNAL OF IMMUNOLOGY

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epicutaneous Application of Toll-like Receptor 7 Agonists Leads to Systemic Autoimmunity in Wild-Type Mice: A New Model of Systemic Lupus Erythematosus

(2013) Maki Yokogawa et al.   Arthritis & Rheumatology

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

The Lupus-Prone NZM2410/NZW Strain-Derived Sle1b Sublocus Alters the Germinal Center Checkpoint in Female Mice in a B Cell-Intrinsic Manner

(2012) E. B. Wong et al.   JOURNAL OF IMMUNOLOGY

The Yaa Locus and IFN-α Fine-Tune Germinal Center B Cell Selection in Murine Systemic Lupus Erythematosus

(2012) Ioana Moisini et al.   JOURNAL OF IMMUNOLOGY

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest

(2010) Gloria Dimco et al.   CELL CYCLE

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Interferon-α treatment of female (NZW × BXSB)F1mice mimics some but not all features associated with theYaamutation

(2009) Meera Ramanujam et al.   ARTHRITIS AND RHEUMATISM

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

IFN Regulatory Factor 5 Is Required for Disease Development in the Fc RIIB-/-Yaa and Fc RIIB-/- Mouse Models of Systemic Lupus Erythematosus

(2009) C. Richez et al.   JOURNAL OF IMMUNOLOGY

Murine B Cell Response to TLR7 Ligands Depends on an IFN-  Feedback Loop

(2009) N. M. Green et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY

How to map billions of short reads onto genomes

(2009) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

(2009) J. A. Bubier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

(2009) Donna L Thibault et al.   ARTHRITIS RESEARCH & THERAPY

IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

(2008) Donna L. Thibault et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL9, but not CXCL10, Promotes CXCR3-Dependent Immune-Mediated Kidney Disease

(2008) J. Menke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY