The molecular basis for differential type I interferon signaling

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The anti-proliferative effects of type I IFN involve STAT6-mediated regulation of SP1 and BCL6

(2016) Yu-An Hsu et al.   CANCER LETTERS

A Potent In Vivo Antitumor Efficacy of Novel Recombinant Type I Interferon

(2016) Kang-Jian Zhang et al.   CLINICAL CANCER RESEARCH

Interferon alpha antagonizes STAT3 and SOCS3 signaling triggered by hepatitis C virus

(2016) Lan-Juan Zhao et al.   CYTOKINE

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

(2016) Katarzyna Blaszczyk et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Response to interferons and antibacterial innate immunity in the absence of tyrosine‐phosphorylated STAT1

(2016) Andrea Majoros et al.   EMBO REPORTS

Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation

(2016) Jun Gui et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

(2016) John R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG15 deficiency and increased viral resistance in humans but not mice

(2016) Scott D. Speer et al.   Nature Communications

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

(2016) Daniela Chmiest et al.   Nature Communications

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

(2016) Yuliya V. Katlinskaya et al.   Cell Reports

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

(2016) Johnathan Ho et al.   PLOS BIOLOGY

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

(2015) Katarzyna Blaszczyk et al.   BIOCHEMICAL JOURNAL

Cut, copy, move, delete: The study of human interferon genes reveal multiple mechanisms underlying their evolution in amniotes

(2015) Christopher D. Krause et al.   CYTOKINE

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

(2015) Edmond M. Linossi et al.   IMMUNOLOGICAL REVIEWS

Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain

(2015) Nanaocha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Targeting of type I interferon in systemic autoimmune diseases

(2015) Mary K. Crow et al.   Translational Research

The molecular basis for functional plasticity in type I interferon signaling

(2015) Gideon Schreiber et al.   TRENDS IN IMMUNOLOGY

Central Role of ULK1 in Type I Interferon Signaling

(2015) Diana Saleiro et al.   Cell Reports

Fine Tuning of a Type 1 Interferon Antagonist

(2015) Victoria Urin et al.   PLoS One

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

(2014) S. Bhattacharya et al.   EMBO Molecular Medicine

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses

(2014) Surinder Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancedin VivoEfficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis

(2014) Daniel Harari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane

(2014) Sara Löchte et al.   JOURNAL OF CELL BIOLOGY

Influence of type-I Interferon receptor expression level on the response to type-I Interferons in human pancreatic cancer cells

(2014) Stephanie Booy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response

(2014) Daniel Harari et al.   PLoS One

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist

(2014) D. Levin et al.   Science Signaling

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

(2013) HyeonJoo Cheon et al.   EMBO JOURNAL

Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy

(2013) Serge Y. Fuchs   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

(2012) Véronique Francois-Newton et al.   BIOCHEMICAL JOURNAL

Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function

(2012) M. P. Gil et al.   BLOOD

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Type I Interferons Induce Apoptosis by Balancing cFLIP and Caspase-8 Independent of Death Ligands

(2012) A. Apelbaum et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

(2012) S Bhattacharya et al.   ONCOGENE

Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

(2012) Maria V. Chiantore et al.   PLoS One

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

(2012) Laura Icardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2

(2011) Barbara Testoni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

(2011) W.-B. Wang et al.   JOURNAL OF IMMUNOLOGY

Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

(2011) D. Levin et al.   MOLECULAR AND CELLULAR BIOLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

Functional Immobilization and Patterning of Proteins by an Enzymatic Transfer Reaction

(2010) Sharon Waichman et al.   ANALYTICAL CHEMISTRY

NMR Mapping of the IFNAR1-EC Binding Site on IFNα2 Reveals Allosteric Changes in the IFNAR2-EC Binding Site

(2010) Sabine Ruth Akabayov et al.   BIOCHEMISTRY

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

(2010) Johanna K Sandling et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Major Differences in the Responses of Primary Human Leukocyte Subsets to IFN- 

(2010) A. H. H. van Boxel-Dezaire et al.   JOURNAL OF IMMUNOLOGY

Resistance to IFN- -Induced Apoptosis Is Linked to a Loss of STAT2

(2010) A. L. Romero-Weaver et al.   MOLECULAR CANCER RESEARCH

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

(2009) I. Moraga et al.   MOLECULAR AND CELLULAR BIOLOGY

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-independent pathway that controls stability of interferon alpha receptor

(2008) Jianghuai Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutation of the IFNAR-1 Receptor Binding Site of Human IFN-α2 Generates Type I IFN Competitive Antagonists†

(2008) Manjing Pan et al.   BIOCHEMISTRY

Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif

(2008) K. G. Suresh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities

(2008) Eyal Kalie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand Binding Induces a Conformational Change in ifnar1 that Is Propagated to Its Membrane-Proximal Domain

(2008) Jennifer Julia Strunk et al.   JOURNAL OF MOLECULAR BIOLOGY

INTERFEROME: the database of interferon regulated genes

(2008) Shamith A. Samarajiwa et al.   NUCLEIC ACIDS RESEARCH

Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon

(2008) Cyril X. George et al.   VIROLOGY

The EM Structure of a Type I Interferon–Receptor Complex Reveals a Novel Mechanism for Cytokine Signaling

(2007) Zongli Li et al.   JOURNAL OF MOLECULAR BIOLOGY