IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression

(2015) Xiaoming Lu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production

(2015) Shaun W Jackson et al.   CURRENT OPINION IN IMMUNOLOGY

B Cell–Intrinsic CD84 and Ly108 Maintain Germinal Center B Cell Tolerance

(2015) Eric B. Wong et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Blockade of Interferon-γ Normalizes Interferon-Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus

(2015) Andrew A. Welcher et al.   Arthritis & Rheumatology

Excessive Production of IFN-  in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B

(2014) M. Harigai et al.   JOURNAL OF IMMUNOLOGY

Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

(2014) S. W. Jackson et al.   JOURNAL OF IMMUNOLOGY

B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

(2014) Chetna Soni et al.   JOURNAL OF IMMUNOLOGY

Rationale for B cell targeting in SLE

(2014) Iñaki Sanz   Seminars in Immunopathology

The unique features of follicular T cell subsets

(2013) Julie Tellier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

(2013) Z. Hua et al.   JOURNAL OF IMMUNOLOGY

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

(2012) Anatoly V. Rubtsov et al.   IMMUNOLOGIC RESEARCH

The Lupus-Prone NZM2410/NZW Strain-Derived Sle1b Sublocus Alters the Germinal Center Checkpoint in Female Mice in a B Cell-Intrinsic Manner

(2012) E. B. Wong et al.   JOURNAL OF IMMUNOLOGY

IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice

(2012) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired clearance of apoptotic cells in germinal centers: implications for loss of B cell tolerance and induction of autoimmunity

(2011) Ziaur S. M. Rahman   IMMUNOLOGIC RESEARCH

Tolerogenic function of Blimp-1 in dendritic cells

(2011) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

(2011) Takuya Nojima et al.   Nature Communications

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice

(2010) Thomas Tiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner

(2010) J. Bessa et al.   JOURNAL OF IMMUNOLOGY

Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus

(2009) K. Kim et al.   ANNALS OF THE RHEUMATIC DISEASES

The Lupus Susceptibility Locus Sle1 Breaches Peripheral B Cell Tolerance at the Antibody-Forming Cell and Germinal Center Checkpoints

(2009) R. Vuyyuru et al.   JOURNAL OF IMMUNOLOGY

IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

(2008) Donna L. Thibault et al.   JOURNAL OF CLINICAL INVESTIGATION