Article
Immunology
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Summary: This study aims to develop a malaria vaccine that provides cross-strain protection. Results showed that inoculation of mice with a heterologous live-vaccine prevented the development of experimental cerebral malaria (ECM) and protected the blood-organ barriers from infection. The immune response induced by the live vaccine included cross-reactive antibodies and IL-10-mediated host protection against ECM.
Article
Immunology
Frank Wunderlich, Denis Delic, Daniela Gerovska, Marcos J. Arauzo-Bravo
Summary: This study found that protective vaccination can accelerate extramedullary hepatic megakaryo-/thrombopoiesis in response to malaria. Vaccinated mice showed higher expression levels of megakaryo-/thrombocytic genes in the liver at early stages of infection compared to non-vaccinated mice.
Article
Immunology
Yorjagis Mendez-Cortina, Ana Lucia Rodriguez-Perea, Mateo Chvatal-Medina, Tulio Jose Lopera, Natalia Alvarez-Mesa, Jan Karlo Rodas-Marin, Diana Carolina Moncada, Maria Teresa Rugeles, Paula Andrea Velilla
Summary: This study aimed to characterize B cell subsets and neutralizing responses in COVID-19 patients according to disease severity through a one-month follow-up. The humoral immune response was found to be variable among SARS-CoV-2 infected people depending on the severity and time of clinical evolution. In severe COVID-19 patients, a higher plasmablast frequency and neutralizing antibody response were observed, suggesting a late and potentially limited impact on disease outcome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Gunjan Mandal, Subir Biswas, Carmen M. Anadon, Xiaoqing Yu, Chandler D. Gatenbee, Sandhya Prabhakaran, Kyle K. Payne, Ricardo A. Chaurio, Alexandra Martin, Patrick Innamarato, Carlos Moran, John J. Powers, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Kristen E. Rigolizzo, Xuefeng Wang, Tyler J. Curiel, Paulo C. Rodriguez, Alexander R. Anderson, Ozlen Saglam, Jose R. Conejo-Garcia
Summary: This study reveals the crucial role of humoral immunity in human endometrial cancer and provides insights for the development of novel immunotherapies against this prevalent malignancy. Coordinated cellular and humoral immune responses, particularly involving B cells and IgA:plgR interactions, determine the progression of endometrial cancer and its response to treatment.
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chenfei He, Shan Wang, Chikai Zhou, Minghui He, Jin Wang, Marcus Ladds, Danai Lianoudaki, Saikiran K. Sedimbi, David P. Lane, Lisa S. Westerberg, Shuijie Li, Mikael C. Karlsson
Summary: CD36 plays a critical role in regulating macro-autophagy in B cells, and its deficiency impairs the humoral immune response, leading to reduced plasma cell formation, mitochondrial mobilization, and oxidative phosphorylation. CD36 also regulates autophagy and is involved in T-cell-dependent immune responses.
Article
Cell Biology
Kamalakannan Vijayan, Ganesh Ram R. Visweswaran, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L. Brown, Alexander Watson, Meghan Zuck, Nicholas Dambrauskas, Andrew Raappana, Sara Carbonetti, Laurel Kelnhofer-Millevolte, Elizabeth K. K. Glennon, Rachel Postiglione, D. Noah Sather, Alexis Kaushansky
Summary: The study demonstrates that non-neutralizing antibodies can interfere with the efficacy of malaria vaccination, impacting the immune response.
Article
Immunology
Huan Huang, Hao Ran, Xiaoxi Liu, Lu Yu, Li Qiu, Zhongqiang Lin, Changyi Ou, Yaru Lu, Wenhao Yang, Weibin Liu
Summary: The study found that leflunomide can alleviate the severity of EAMG by regulating humoral immune responses and balancing Th cell subsets, potentially by inhibiting Tfh cells and reducing antibody secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Kai J. Rogers, Rahul Vijay, Noah S. Butler
Summary: Humoral immunity plays a critical role in limiting Plasmodium parasite infections and the severity of malaria. Naturally acquired immunity against malaria is inefficient and protection is relatively short-lived. Recent advances have been made in understanding the molecular and cellular pathways that regulate Plasmodium parasite-specific B cell responses and durable anti-malarial humoral immunity.
MICROBES AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
J. Timothy Prior, Christopher Davitt, Jonathan Kurtz, Patrick Gellings, James B. McLachlan, Lisa A. Morici
Summary: OMVs have the potential to function as a stand-alone adjuvant, driving stronger immune responses compared to heat-inactivated and live-attenuated bacteria. They induce robust humoral and cellular immune responses, generating stronger antibody and B cell responses than traditional adjuvants, while remaining unaffected by pre-existing antibodies.
Review
Immunology
Cayce E. Dorrier, Dorian B. McGavern
Summary: Infiltration of peripheral B cells into the CNS provides defense against neurotropic infections but can also contribute to neuroinflammatory diseases. The meninges serve as an important site for B-cell development and tolerance, as well as a location for plasma cells to secrete antibodies and sequester pathogens. However, pathological responses, such as the development of ectopic lymphoid structures in the meninges, can promote autoimmune damage in the CNS.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Immunology
Glaivy Batsuli, Jasmine Ito, Elizabeth S. York, Courtney Cox, Wallace Baldwin, Surinder Gill, Pete Lollar, Shannon L. Meeks
Summary: This study analyzed the internalization of FVIII complexed with epitope-mapped FVIII-specific IgG monoclonal antibodies by murine bone marrow-derived dendritic cells (BMDCs) in vitro, as well as the antibody development in hemophilia A (FVIII-/-) mice injected with FVIII-IC over time. The results showed that certain FVIII-IC subsets modulate the humoral response to FVIII in an epitope-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Joji Ishida, Saira Alli, Andrew Bondoc, Brian Golbourn, Nesrin Sabha, Kristina Mikloska, Stacey Krumholtz, Dilakshan Srikanthan, Naohide Fujita, Amanda Luck, Colin Maslink, Christian Smith, Kullervo Hynynen, James Rutka
Summary: Diffuse intrinsic pontine glioma (DIPG) is a devastating tumor in children that cannot be surgically removed, and MRI-guided focused ultrasound (MRgFUS) shows promise in enhancing drug delivery for DIPG treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Ramin Sedaghat Herati, David A. Knorr, Laura A. Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A. Apostolidis, Alexander C. Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P. Staupe, Sharon A. Adamski, Senthil Kannan, Raj K. Kurupati, Hildegund C. J. Ertl, Jeffrey L. Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M. Schuchter, Ritesh R. Kotecha, Samuel A. Funt, Martin H. Voss, Robert J. Motzer, Chung-Han Lee, Dean F. Bajorin, Tara C. Mitchell, Jeffrey Ravetch, E. John Wherry
Summary: Anti-PD-1 immunotherapy has dynamic effects on noncancer immune responses, enhancing the Tfh-B cell axis response to influenza vaccination and potentially affecting immune predisposition.
Article
Immunology
Edmond J. Remarque, Bart W. Faber, Roberto Rodriguez Garcia, Herman Oostermeijer, Sodiomon B. Sirima, Issa Nebie Ouedraogo, Leila Kara, Odile Launay, Sophie Houard, Odile Leroy, Clemens H. M. Kocken
Summary: The study designed DiCo protein sequences to address the polymorphism of PfAMA1 antigen and found that vaccination of malaria-exposed adults led to significant increases in antibody levels to DiCo variants, but not to naturally occurring PfAMA1 variants.
