Pyroptosis in diabetic nephropathy

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

(2021) Kohsuke Tsuchiya   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electro-acupuncture Protects diabetic nephropathy-induced inflammation through suppression of NLRP3 inflammasome in Renal macrophage isolation

(2021) Jieying Zhang et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

(2021) Ming Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis

(2020) Si Wen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Recent Advances in Lipopolysaccharide Recognition Systems

(2020) Lalita Mazgaeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2020) Yanyan Zhu et al.   PHARMACOLOGICAL RESEARCH

LncRNA MALAT1 promoted high glucose‐induced pyroptosis of renal tubular epithelial cell by sponging miR ‐30c targeting for NLRP3

(2020) Chan Liu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway

(2020) Xin An et al.   Nutrients

Polysaccharides from Armillariella tabescens mycelia ameliorate renal damage in type 2 diabetic mice

(2020) Rui Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

RIPK3 blockade attenuates tubulointerstitial fibrosis in a mouse model of diabetic nephropathy

(2020) Ying Shi et al.   Scientific Reports

Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera

(2020) Manel Dhahri et al.   ACS Omega

LncRNA-antisense non-coding RNA in the INK4 locus promotes pyroptosis via miR-497/thioredoxin-interacting protein axis in diabetic nephropathy

(2020) Jia Wang et al.   LIFE SCIENCES

Differential role of the NLRP3 inflammasome in infection and tumorigenesis

(2019) Sarang Tartey et al.   IMMUNOLOGY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Luteolin attenuates high glucose-induced podocyte injury via suppressing NLRP3 inflammasome pathway

(2019) Qian Yu et al.   LIFE SCIENCES

MicroRNAs as important regulators of the NLRP3 inflammasome

(2019) Parvin Zamani et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies

(2019) Gulcin Tezcan et al.   Frontiers in Pharmacology

Enzymatically Synthesized Ginsenoside Exhibits Antiproliferative Activity in Various Cancer Cell Lines

(2019) Sumangala Darsandhari et al.   Applied Sciences-Basel

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA

(2019) Fan Yang et al.   Molecular Therapy-Nucleic Acids

A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway

(2019) Ya-Jing Chen et al.   BRAIN RESEARCH BULLETIN

Mitochondrial dysfunction in diabetic kidney disease

(2019) Pascal Zhongping Wei et al.   CLINICA CHIMICA ACTA

Gasdermins and their role in immunity and inflammation

(2019) Pontus Orning et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis

(2019) Shuai Jiang et al.   JOURNAL OF IMMUNOLOGY

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation

(2019) CongXiao Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Gasdermin D activity in inflammation and host defense

(2019) Judy Lieberman et al.   Science Immunology

Long noncoding RNA KCNQ1OT1 induces pyroptosis in diabetic corneal endothelial keratopathy.

(2019) Yanyan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy

(2019) Lei Du et al.   CELL BIOLOGY AND TOXICOLOGY

Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis

(2019) Junling Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway

(2019) Jinni Hong et al.   Frontiers in Cell and Developmental Biology

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer’s disease

(2019) Priya Kashyap et al.   STEROIDS

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review

(2019) Kai Yuan et al.   Frontiers in Pharmacology

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways

(2018) Xiaoguang Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats

(2018) Yao-Wu Liu et al.   PHYTOTHERAPY RESEARCH

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway

(2018) Yang Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2018) Wu Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Targeting inflammation in diabetic nephropathy: a tale of hope

(2018) Juan Antonio Moreno et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway

(2018) Shan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis

(2018) Jiacai Hu et al.   BIOCHIMIE

Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses

(2017) Young-Su Yi   IMMUNOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy

(2017) Giacomo Garibotto et al.   JOURNAL OF NEPHROLOGY

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

(2017) Miaomiao Lu et al.   Biomed Research International

Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway

(2017) Yi Liu et al.   Scientific Reports

MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis

(2017) Heming Chen et al.   Scientific Reports

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats

(2016) Long Hongyan et al.   BIOMEDICINE & PHARMACOTHERAPY

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

The intersection of cell death and inflammasome activation

(2016) James E. Vince et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy

(2016) Kate Simpson et al.   Current Diabetes Reports

NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus

(2016) Tatiana N. Silveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats

(2016) Il-Dong Choi et al.   Evidence-based Complementary and Alternative Medicine

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator–activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats

(2016) Jing Ge et al.   JOURNAL OF ETHNOPHARMACOLOGY

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome

(2016) Yara A. Samra et al.   LIFE SCIENCES

miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy

(2016) Yan Sun et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

(2016) Ping Yang et al.   MOLECULES

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

(2016) Manohar Salla et al.   ACS Medicinal Chemistry Letters

Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue

(2016) Weijie Chen et al.   Journal of Ginseng Research

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

A review of biotransformation and pharmacology of ginsenoside compound K

(2015) Xi-Ding Yang et al.   FITOTERAPIA

Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid

(2015) Zhi-Min Mao et al.   JOURNAL OF ETHNOPHARMACOLOGY

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

(2015) Ji-Yeon Yu et al.   MOLECULES

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway

(2015) Xiao Zhou et al.   RNA Biology

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

Efficacy and Safety of Abelmoschus manihot for Primary Glomerular Disease: A Prospective, Multicenter Randomized Controlled Clinical Trial

(2014) Li Zhang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats

(2014) Amit D. Kandhare et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Polyphenols protect against protein glycoxidation

(2014) Izabela Sadowska-Bartosz et al.   FREE RADICAL BIOLOGY AND MEDICINE

The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology

(2014) Yingli Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica

(2014) Leonardo C. Monção-Ribeiro et al.   PLoS One

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Pattern recognition receptors in innate immunity, host defense, and immunopathology

(2013) Rahul Suresh et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats

(2013) Yue Tu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Urine miRNAs: Potential biomarkers for monitoring progression of early stages of diabetic nephropathy

(2013) Yeyi Yang et al.   MEDICAL HYPOTHESES

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia

(2012) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Sarsasapogenin Increases Melanin Synthesis via Induction of Tyrosinase and Microphthalmia-Associated Transcription Factor Expression in Melan-a Cells

(2012) Eun-Jung Moon et al.   Biomolecules & Therapeutics

Dihydroquercetin: More than just an impurity?

(2012) Anita Elaine Weidmann   EUROPEAN JOURNAL OF PHARMACOLOGY

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway

(2010) Cairong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy

(2009) A. Advani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure

(2009) Hong-Bo Luo et al.   Neuroscience Bulletin

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy

(2008) K Tikoo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

Luteolin Suppresses Cisplatin-Induced Apoptosis in Auditory Cells: Possible Mediation Through Induction of Heme Oxygenase-1 Expression

(2008) Byung-Min Choi et al.   JOURNAL OF MEDICINAL FOOD

Review of Pharmacological Effects ofGlycyrrhiza sp. and its Bioactive Compounds

(2008) Marjan Nassiri Asl et al.   PHYTOTHERAPY RESEARCH

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE