Article
Clinical Neurology
Kana Ueki, Ryu Matsuo, Takahiro Kuwashiro, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono
Summary: This study aimed to determine whether kidney dysfunction or kidney damage, or both, are associated with long-term outcomes after ischemic stroke. The results showed that both kidney dysfunction and kidney damage were independently associated with increased risks of recurrent stroke and all-cause death.
Article
Hematology
Vimal K. Derebail, Qingning Zhou, Emily J. Ciccone, Jianwen Cai, Kenneth I. Ataga
Summary: In adult sickle cell disease patients, hyperfiltration is common, especially in younger individuals, and the likelihood of returning to normal glomerular filtration rate is significantly higher in males. This may indicate kidney function loss rather than improvement in hyperfiltration.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongmei Yu, Mei Wang, Jingshi Yu, Haitao Tang, Qing Xu, Ning Cheng, Xiaoxiao Luo, Yurong Wang, Haitao Ge, Lei Qiang, Wei Tang, Harvest F. Gu
Summary: The Huangkui capsule, a traditional Chinese medicine, has been used as a treatment for kidney diseases, especially diabetic nephropathy. This study found that the capsule can reduce albuminuria and proteinuria, as well as increase the number of nephrons in the kidneys, providing experimental evidence of its medical efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Lei Zhao, Siyuan Han, Chengzhi Chai
Summary: The study suggests that Huangkui capsule may protect podocytes and improve proteinuria by modulating the JAK2/STAT3 and PI3K/Akt signaling pathways. The results demonstrate the significant therapeutic effect of Huangkui capsule on proteinuria and its protective role in podocyte damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Francesco Cei, Ludia Chiarugi, Simona Brancati, Maria Silvia Montini, Silvia Dolenti, Daniele Di Stefano, Salvatore Beatrice, Irene Sellerio, Valentina Messiniti, Marco Maria Gucci, Giulia Vannini, Rinaldo Lavecchia, Elisa Cioni, Chiara Mattaliano, Giulia Pelagalli, Grazia Panigada, Emanuele Murgo, Gianluigi Mazzoccoli, Giancarlo Landini, Roberto Tarquini
Summary: This study retrospectively analyzed consecutive acute COVID-19 hospitalized patients and found that estimated GFR (eGFR) assessed at hospital admission can effectively identify acute renal function derangement and is independently associated with in-hospital mortality. However, there is no association between eGFR and both ARDS and need for mechanical ventilation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yuzhou Wan, Shaopeng Wang, Kexu Chen, Lin Liu, Xiaoqian Wang, Bo Zhang, Lin Hu, Shunmei Liu, Tingting Zhao, Huimin Qi
Summary: This study found that the high-sulfated derivative of Ulva pertusa polysaccharide (HU) can attenuate the symptoms of nephrotic syndrome (NS) in rats by regulating the Keap1/Nrf2 signaling pathway, including reducing urine protein, improving kidney function, and reducing lipid metabolism abnormalities.
Article
Urology & Nephrology
Tyrone G. Harrison, Shannon M. Ruzycki, Matthew T. James, Paul E. Ronksley, Kelly B. Zarnke, Marcello Tonelli, Braden J. Manns, Deirdre McCaughey, Prism Schneider, Elijah Dixon, Rebecca L. Hartley, Victoria S. Owen, Zhihai Ma, Brenda R. Hemmelgarn
Summary: People with reduced kidney function have a significantly higher incidence of major surgery compared to those with normal kidney function, with age and sex modifying this risk. Men under 65 years old receiving maintenance dialysis experienced the highest rates of major surgery.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Review
Integrative & Complementary Medicine
Wei Li, Ping Xia, Wei Sun, Jing Zhao, Qiong Liu, Lianyi Geng, Yao Zhou, Kun Gao
Summary: This study aimed to collect data and investigate the effects of Huangkui capsule on chronic kidney disease. Relevant articles were searched and randomized controlled trials using Huangkui capsule for treating chronic kidney disease were reviewed. The results showed that Huangkui capsule significantly lowered blood urea nitrogen, serum creatinine, and 24-hour urine protein content, and improved glomerular filtration rate and serum albumin level. However, further high-quality randomized controlled trials with larger sample sizes are needed to confirm these findings.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mohammad Hamidi, Catherine L. O'Grady, Sacha D. Brown, Amanda K. Arrington, Lilah Morris-Wiseman, Taylor S. Riall, Mohammad Khreiss
Summary: Lower preoperative eGFR levels (<60 mL/min/1.73m(2)) in patients undergoing pancreatectomy are associated with adverse outcomes, including prolonged length of stay, adverse discharge disposition, higher complication rates, and increased mortality risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Medicine, General & Internal
Andrzej Konieczny, Piotr Donizy, Tomasz Golebiowski, Andrzej Tukiendorf, Agnieszka Halon, Mariusz Kusztal, Hanna Augustyniak-Bartosik, Magdalena Krajewska
Summary: This study analyzed clinical and histopathological data from 80 patients with IgA nephropathy, and found that endocapillary hypercellularity and interstitial fibrosis were predictors of eGFR decline, while serum albumin concentration had a protective impact on eGFR deterioration. The presence of endocapillary hypercellularity and extent of interstitial fibrosis also negatively correlated with the reduction in proteinuria below 1.0 g/24 h.
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Medicine, General & Internal
Jonathan R. Genzen, Rhona J. Souers, Lauren N. Pearson, David M. Manthei, Allison B. Chambliss, Zahra Shajani-Yi, W. Greg Miller
Summary: This study examines the awareness and adoption of new equations for estimated glomerular filtration rate (eGFR) in clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022. The new equations, proposed by the Chronic Kidney Disease Epidemiology Collaboration, eliminate race-adjustment factors and include equations based on creatinine alone or a combination of creatinine and cystatin C.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Plant Sciences
Xuefeng Sun, Ping Li, Hongli Lin, Zhaohui Ni, Yongli Zhan, Guangyan Cai, Chao Liu, Qinkai Chen, Wenge Wang, Xiaoqin Wang, Peiqing Zhang, Peng Li, Meng Liang, Hongguang Zheng, Niansong Wang, Lining Miao, Ruixia Jin, Zhiyong Guo, Yong Wang, Xiangmei Chen
Summary: This study aimed to evaluate the safety and efficacy of Abelmoschus manihot (AM) in treating various types of chronic kidney disease (CKD) in combination with other medications. The results showed that AM, when used in combination, reduced proteinuria and maintained stable kidney function.
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.