MicroRNAs and other non-coding RNAs as targets for anticancer drug development

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

(2013) H. Ling et al.   GENOME RESEARCH

Targeting long non-coding RNAs in cancers: Progress and prospects

(2013) Chi Han Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The effect of Bcl-2 siRNA combined with miR-15a oligonucleotides on the growth of Raji cells

(2013) Xiaomao Hu et al.   MEDICAL ONCOLOGY

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

The shaping and functional consequences of the microRNA landscape in breast cancer

(2013) Heidi Dvinge et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Control of metastatic progression by microRNA regulatory networks

(2013) Nora Pencheva et al.   NATURE CELL BIOLOGY

Biotech comes to its 'antisenses' after hard-won drug approval

(2013) Kevin Jiang   NATURE MEDICINE

Targeting long non-coding RNA to therapeutically upregulate gene expression

(2013) Claes Wahlestedt   NATURE REVIEWS DRUG DISCOVERY

Micromanaging Hepatitis C Virus

(2013) Judy Lieberman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11

(2013) Jessica Bockhorn et al.   Nature Communications

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas

(2012) Y. Zhang et al.   BLOOD

The Therapeutic Potential of MicroRNAs in Cancer

(2012) Stine B. Thorsen et al.   CANCER JOURNAL

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells

(2012) Maria I. Almeida et al.   GASTROENTEROLOGY

Diagnostic Performance of PCA3 to Detect Prostate Cancer in Men with Increased Prostate Specific Antigen: A Prospective Study of 1,962 Cases

(2012) E. David Crawford et al.   JOURNAL OF UROLOGY

Europe gives gene therapy the green light

(2012) Karl Gruber   LANCET

Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

(2012) Stefan Uhlmann et al.   Molecular Systems Biology

Targeting nuclear RNA for in vivo correction of myotonic dystrophy

(2012) Thurman M. Wheeler et al.   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

AntagoNATs boost gene expression

(2012) Nicole Rusk   NATURE METHODS

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

(2012) Jun Xie et al.   NATURE METHODS

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Pioneering gene therapy on brink of approval

(2012) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1

(2012) S Yang et al.   ONCOGENE

Long non-coding RNAs and cancer: a new frontier of translational research?

(2012) R Spizzo et al.   ONCOGENE

Cell-to-cell miRNA transfer: From body homeostasis to therapy

(2012) Roxana S. Redis et al.   PHARMACOLOGY & THERAPEUTICS

Rapid Generation of MicroRNA Sponges for MicroRNA Inhibition

(2012) Joost Kluiver et al.   PLoS One

Inhibition of Neuroblastoma Tumor Growth by Targeted Delivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles

(2012) Amanda Tivnan et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ENCODE Project Writes Eulogy for Junk DNA

(2012) E. Pennisi   SCIENCE

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Developing therapeutic microRNAs for cancer

(2011) A G Bader et al.   GENE THERAPY

Association of a MicroRNA/TP53 Feedback Circuitry With Pathogenesis and Outcome of B-Cell Chronic Lymphocytic Leukemia

(2011) Muller Fabbri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Development of microRNA-145 for therapeutic application in breast cancer

(2011) Seok-Jun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Tumor-specific Expression of MicroRNA-26a Suppresses Human Hepatocellular Carcinoma Growth via Cyclin-dependent and -independent Pathways

(2011) Lizao Chen et al.   MOLECULAR THERAPY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) Konstantinos J Mavrakis et al.   NATURE GENETICS

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

(2011) Loïc de Pontual et al.   NATURE GENETICS

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis

(2011) Hanyin Cheng et al.   PLoS One

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

(2011) S. Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

(2010) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets

(2010) M. Girardot et al.   BLOOD

Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells

(2010) Lili Jiang et al.   BMC CANCER

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

(2010) Mark E. Hatley et al.   CANCER CELL

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells

(2010) Ai Kotani et al.   CELL CYCLE

Targeting MicroRNAs With Small Molecules: From Dream to Reality

(2010) S Zhang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reprogramming of miRNA networks in cancer and leukemia

(2010) S. Volinia et al.   GENOME RESEARCH

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

(2010) Li Ma et al.   NATURE BIOTECHNOLOGY

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

(2010) Alexander Swarbrick et al.   NATURE MEDICINE

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

(2010) Lucy Pigati et al.   PLoS One

Serum miRNA-21: Elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy

(2010) Hai-Liang Zhang et al.   PROSTATE

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Evidence for human microRNA-offset RNAs in small RNA sequencing data

(2009) D. Langenberger et al.   BIOINFORMATICS

miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221

(2009) A. Kotani et al.   BLOOD

Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer

(2009) Sylwia E. Wojcik et al.   CARCINOGENESIS

MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift

(2009) M. Fabbri et al.   CARCINOGENESIS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

SnapShot: MicroRNAs in Cancer

(2009) Riccardo Spizzo et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

(2009) Scott Valastyan et al.   CELL

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

Epigenetic regulation of microRNA expression in colorectal cancer

(2009) Eva Bandres et al.   INTERNATIONAL JOURNAL OF CANCER

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Tiny RNAs associated with transcription start sites in animals

(2009) Ryan J Taft et al.   NATURE GENETICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Regulatory roles of natural antisense transcripts

(2009) Mohammad Ali Faghihi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer

(2009) Junfang Ji et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from snoRNAs

(2009) R. J. Taft et al.   RNA

The Genetic Signatures of Noncoding RNAs

(2009) John S. Mattick   PLoS Genetics

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3

(2008) Wing Pui Tsang et al.   APOPTOSIS

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

(2008) Yvonne Tay et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

(2008) Qihong Huang et al.   NATURE CELL BIOLOGY

Endogenous small interfering RNAs in animals

(2008) Katsutomo Okamura et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potent inhibition of microRNA in vivo without degradation

(2008) Scott Davis et al.   NUCLEIC ACIDS RESEARCH

MiR-15a and miR-16-1 cluster functions in human leukemia

(2008) George A. Calin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

(2008) J. J. Forman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA