Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy

(2019) Shan Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small GTPase Arf6 regulates diabetes-induced cholesterol accumulation in podocytes

(2019) Jijia Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

(2019) A. Mitrofanova et al.   Nature Communications

Podocyte lipotoxicity in diabetic kidney disease

(2019) Hiroshi Nishi et al.   KIDNEY INTERNATIONAL

Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

(2019) Yifei Zhong et al.   Nature Communications

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Understanding Podocyte Biology to Develop Novel Kidney Therapeutics

(2018) Mark A. Lal et al.   Frontiers in Endocrinology

Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia

(2017) Sabena M. Conley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Palmitate induces mitochondrial superoxide generation and activates AMPK in podocytes

(2017) Eugene Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury

(2017) Li Zhang et al.   KIDNEY INTERNATIONAL

Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN)

(2017) Yang Yuan et al.   Lipids in Health and Disease

Fenofibrate attenuates fatty acid-induced islet β-cell dysfunction and apoptosis via inhibiting the NF-κB/MIF dependent inflammatory pathway

(2017) Shuang Zheng et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction

(2017) Yi Zhang et al.   Cell Death & Disease

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes

(2016) Stéphanie Eid et al.   ANTIOXIDANTS & REDOX SIGNALING

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

Inflammatory stress exacerbates lipid accumulation and podocyte injuries in diabetic nephropathy

(2015) Yang Zhang et al.   ACTA DIABETOLOGICA

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Fine-tuning of NFκB by glycogen synthase kinase 3β directs the fate of glomerular podocytes upon injury

(2015) Hui Bao et al.   KIDNEY INTERNATIONAL

Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes

(2014) S. Motonishi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function

(2013) Fitsum Guebre-Egziabher et al.   BIOCHIMIE

Cholesterol Accumulation in Podocytes: A Potential Novel Targetable Pathway in Diabetic Nephropathy

(2013) A. Tufro   DIABETES

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism

(2012) Wei Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation

(2010) M. Murea et al.   Clinical Journal of the American Society of Nephrology

Interleukin-1β enhances the intracellular accumulation of cholesterol by up-regulating the expression of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in podocytes

(2010) Gaofu Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007

(2008) P. Fioretto et al.   DIABETOLOGIA

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

The pathogenesis of diabetic nephropathy

(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism