Article
Biochemistry & Molecular Biology
Kunfeng Zhang, Yuzhe Huang, Qianzhen Wu, Wenhua Guo, Hao Chen, Wenna Zhang, Yong Li, Yongming Lu, Qingxi Wu, Wenjuan Pan, Lei Chen, Yan Chen
Summary: The study aimed to prepare Armillariella tabescens mycelia polysaccharides (PAT) with potent inhibitory effect on food-borne pathogenic bacteria and investigate its antibacterial mechanism. The results showed that PAT inhibited the growth of various bacterial species and induced cell wall and membrane rupture. Moreover, PAT increased broth conductivity, protein exudation, and enzyme activities, and caused morphological changes, reactive oxygen species accumulation, and cell apoptosis in treated bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Rui Yang, Yuanyuan Wang, Shomaila Mehmood, Min Zhao, Xingxing Yang, Ying Li, Wei Wang, Jinwu Chen, Qiang Jia
Summary: This study demonstrated that polysaccharides from Armillariella tabescens mycelia (AT) have a potent anti-inflammatory effect and can improve the symptoms of dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice. AT treatment increased the abundance of beneficial bacteria, improved colonic barrier function, and reduced colonic inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Urology & Nephrology
Hoang Thuy Linh, Yasunori Iwata, Yasuko Senda, Yukiko Sakai-Takemori, Yusuke Nakade, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi, Norihiko Sakai, Hiroyuki Yamada, Katsuhiko Asanuma, Kouji Matsushima, Takashi Wada
Summary: Impairment of intestinal barrier function is associated with the progression of diabetic kidney disease, and abnormal MAVS signaling in the kidney and intestine contributes to disrupted intestinal homeostasis. Controlling intestinal homeostasis may offer a novel therapeutic approach for diabetic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Plant Sciences
Tian Lan, Tang Tang, Ying Li, Yingling Duan, Qin Yuan, Wen Liu, Yuqing Ren, Ning Li, Xuenan Liu, Yu Zhang, Xinglong Li, Guifang Jin, Shengpeng Wang, Jiao Guo
Summary: This study aimed to investigate the beneficial effects of polysaccharide components in FTZ (FTZPs) in DKD mice via the gut-kidney axis. The results showed that FTZPs can treat DKD by altering SCFAs levels and the gut microbiome.
Review
Medicine, Research & Experimental
Soumik Das, Ramanathan Gnanasambandan
Summary: A significant portion of the health burden of diabetic kidney disease (DKD) is caused by both type 1 and type 2 diabetes. Inflammation triggered by gut microbiota is commonly associated with the development of DKD. The fundamental processes through which the gut microbiota affects the onset and progression of DKD are mainly unknown.
Article
Food Science & Technology
Wen-Na Zhang, Yuan -Yuan Li, Jia-Jia Xu, Lu-Lu Shi, Lei Chen, Yong-Ming Lu, Qing-Xi Wu, Jian-Guang Luo, Yan Chen
Summary: Armillariella tabescens methanol extract (AME) has been found to have significant therapeutic effects on ulcerative colitis (UC), including reducing symptoms, increasing anti-inflammatory factors, and inhibiting inflammation signaling pathways. It also improves the expression of tight junction proteins. This study suggests that AME has the potential to be developed into a promising therapeutic agent for UC treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Endocrinology & Metabolism
C. M. Mosterd, M. Kanbay, B. J. H. van den Born, D. H. van Raalte, E. Rampanelli
Summary: Diabetic kidney disease is a growing burden on public health and the leading cause of end-stage kidney diseases. Interactions between host-gut microbiota have emerged as essential for maintaining host homeostasis, particularly evident in the bidirectional microbiota-kidney crosstalk during progressive kidney dysfunction, leading to a vicious cycle of dysbiosis and renal dysfunction.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Applied
Wangting Zhou, Tingting Yang, Weiqi Xu, Yujie Huang, Linwu Ran, Yamei Yan, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao
Summary: The study found that polysaccharides from the fruits of Lycium barbarum L. (LBPs) can improve blood glucose levels and beta-cell function in diabetic mice by modulating gut microbiota and protecting intestinal barrier function.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Qin Yi Wu, Bi Cheng Liu, Xiong Zhong Ruan, Kun Ling Ma
Summary: This review provides an overview of the structure and biological function of intestinal microbiota-derived membrane vesicles (MVs), highlighting their crucial roles in immunomodulation and maintenance of the intestinal micro-ecosystem. It also explores the relationship between MVs and chronic kidney disease (CKD), as well as the potential pathogenic mechanisms mediated by MVs, which may have significant clinical implications for the diagnosis and treatment of CKD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Xiaona Sun, Yili Liu, Pingrui Jiang, Shuang Song, Chunqing Ai
Summary: This study found that sulfated polysaccharides from pacific abalone can alter the gut microbiota structure and increase relative abundances of certain Bacteroidales members, indicating the important role of intestinal Bacteroidales in the bioactivities of AGSP. Additionally, there is an AGSP utilization network among Bacteroidales species, which influences the anti-inflammatory activity and cytotoxicity of AGSP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Huiling Tang, Zhengqi Zha, Yanfang Tan, Yuan Li, Yuzhi Jiao, Baowei Yang, Qingping Xiong, Hongping Yin, Hang Wang
Summary: A novel polysaccharide called CVP was isolated and purified from Coriolus versicolor and shown to alleviate the symptoms of nonalcoholic fatty liver disease. It achieved this by altering gut microbiota and reducing bile acid-related microbes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Yinghui Huang, Wang Xin, Jiachuan Xiong, Mengying Yao, Bo Zhang, Jinghong Zhao
Summary: This review discusses the role of gut microbiota in chronic kidney disease and its associated complications, as well as the significance of the gut-kidney-heart axis hypothesis in the pathophysiological mechanisms of these diseases. Regulating gut microbiota may serve as a novel therapeutic approach for CKD progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Hye-Bin Lee, Young-Soo Kim, Ho -Young Park
Summary: This review discusses the relationship between the structural characteristics of pectic polysaccharides and the modulatory activity of gut microbiota. It also explores the health benefits of pectic polysaccharides on diet-induced obesity and intestinal health. Through regulating gut microbiota, pectic polysaccharides exert various beneficial biological effects.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
Qi Li, Linyan Li, Qiqiong Li, Junqiao Wang, Shaoping Nie, Mingyong Xie
Summary: The incidence of inflammatory bowel disease (IBD) is increasing, and there is a need for safe and effective treatment methods. Natural polysaccharides (NPs) have attracted attention for their efficiency, low toxicity, and wide range of biological activities in treating IBD. This paper focuses on exploring the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbiota.
Article
Biochemistry & Molecular Biology
Meng Zhang, Licheng Yang, Maomao Zhu, Bing Yang, Yanjun Yang, Xiaobin Jia, Liang Feng
Summary: Evidence suggests that polysaccharides from traditional Chinese medicine, such as Moutan Cortex polysaccharide (MC-Pa), positively affect diabetic kidney disease (DKD) by modulating gut microbiota. MC-Pa administration alleviates hyperglycemia and renal injury, improves intestinal barrier function, reduces proinflammatory mediators, and increases short-chain fatty acid (SCFA) contents in DKD rats. The modulation of gut microbiota by MC-Pa is dose- and time-dependent, and specific gut microbiota phyla and genera are significantly associated with DKD-related indicators.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)