Article
Chemistry, Medicinal
Muhammad Riaz, Lina Tariq Al Kury, Noreen Atzaz, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Shupeng Li
Summary: Carvacrol exhibits significant anti-hyperuricemic and anti-inflammatory effects by regulating the ROS/NRLP3/NF-Kappa B pathway, providing protective effects against joint degeneration, similar to allopurinol treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Cell Biology
Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
Summary: Elevated serum urate concentration is a risk factor for kidney disease development. Through studies on UOX-KO rats, it was found that hyperuricemia-induced autophagy and NLRP3-dependent inflammation play crucial roles in renal damage. Inhibiting autophagy and inflammation may serve as potential therapeutic strategies for uric acid nephropathy.
DISEASE MODELS & MECHANISMS
(2021)
Article
Immunology
Ji-Xiao Zhu, Hai-Yan Yang, Wei-Qiong Hu, Jie Cheng, Yang Liu, Li-Tao Yi, Hong-Yu Cheng
Summary: Luteolin, luteoloside and apigenin can attenuate hyperuricemia by reducing the production and increasing the excretion of uric acid, mediated by inhibiting inflammatory signaling pathways.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Plant Sciences
Jiabao Zhou, Chuanxu Wang, Xuming Zhang, Zhiyuan Wu, Yansheng Wu, Dongdong Li, Jiandong Gao
Summary: The traditional Chinese medicine compound Shizhifang (SZF) has been used for over 20 years and has shown clinical safety and efficacy in treating hyperuricemia-induced renal injury. This study demonstrated that SZF can inhibit pyroptosis in renal tubular cells induced by uric acid by targeting the NLRP3/Caspase-1/GSDMD pathway. SZF was more effective than allopurinol and MCC950 in reducing inflammation, improving renal function, and protecting kidney.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Bin He, Qiangqiang Nie, Feng Wang, Xuming Wang, Yun Zhou, Cheng Wang, Jing Guo, Xueqiang Fan, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: Hyperuricemia can aggravate atherosclerotic plaque-load and promote endothelial cell pyroptosis. It can also increase the levels of serum inflammatory factors. In addition, a high concentration of soluble uric acid can trigger the activation stage of the NLRP3 inflammasome, leading to endothelial cell pyroptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biology
Krasimir Iliev Kraev, Mariela Gencheva Geneva-Popova, Bozhidar Krasimirov Hristov, Petar Angelov Uchikov, Stanislava Dimitrova Popova-Belova, Maria Ilieva Kraeva, Yordanka Mincheva Basheva-Kraeva, Nina Staneva Stoyanova, Vesela Todorova Mitkova-Hristova
Summary: Febuxostat has evolved as a versatile therapeutic agent for gout management, with its primary mechanism involving selective inhibition of xanthine oxidase. It effectively lowers uric acid levels and provides an alternative for patients intolerant to allopurinol. Febuxostat also exhibits cardiovascular safety, nephroprotective effects, and anti-inflammatory properties, suggesting broad applications in various clinical contexts.
Article
Agriculture, Multidisciplinary
Ze-Rui Sun, Hua-Rong Liu, Di Hu, Mao-Si Fan, Ming-Yue Wang, Meng-Fei An, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng
Summary: Ellagic acid (EA) has been shown to effectively regulate hyperuricemia by inhibiting xanthine oxidase and superoxide anion, reducing uric acid levels through the NLRP3 signaling pathway, and improving histopathology in animal models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Immunology
Wanyi Huang, Ziqi Zhang, Yueyang Qiu, Yuan Gao, Yongqiang Fan, Qiang Wang, Qing Zhou
Summary: Implant surgery triggers inflammatory reactions that impact postoperative outcomes. The inflammasome has a crucial role in inflammation, inducing pyroptosis and producing interleukin-1 beta. The activation of the inflammasome in bone healing after implant surgery needs to be studied. Research has focused on metal-induced NLRP3 inflammasome activation due to the prominence of metals as implant materials. This review consolidates knowledge on NLRP3 inflammasome structures, activation mechanisms, and metal-induced NLRP3 inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Lijin Shen, Ya Dong, Mingzhen Li, Zhichao Zhou, Jing Zhang, Yanjie Liu, Wei Zhao
Summary: This study evaluated the change in leukocyte levels caused by hyperuricemia and explored the relationship between leukocyte levels and hypertension in elderly patients. The findings revealed that leukocyte levels were higher in elderly patients with hyperuricemia compared to those without hyperuricemia. Hyperuricemia was found to be an independent risk factor for leukocyte levels and hypertension. Furthermore, chronic inflammation caused by hyperuricemia may be an important pathogenesis of incident hypertension in patients with hyperuricemia.
Article
Pharmacology & Pharmacy
Jingna Zheng, Shiting Gong, Gong Wu, Xiaohong Zheng, Jincan Li, Juan Nie, Yanlu Liu, Baoyi Chen, Yuhong Liu, Ziren Su, Jiannan Chen, Yucui Li
Summary: The purpose of this study was to investigate the protective effects of berberine (BBR) against uric acid (UA)-induced HK-2 cells and unravel their regulatory potential mechanisms. The results showed that BBR significantly reversed the up-regulation of inflammatory factors and LDH, alleviated cell injury by down-regulating apoptosis-related proteins expression and inhibiting the activation of NLRP3. Therefore, BBR may exert its protective effects through the NLRP3 signaling pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Immunology
Salona Roy, Md Arif Ansari, Khushboo Choudhary, Sanjiv Singh
Summary: The article provides a comprehensive understanding of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases. The activation pathways of NLRP3 have emerged as the main target for therapeutic management of depression. The available drug inhibitors for NLRP3 in preclinical and clinical trials are discussed in detail.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yoshitaka Kimura, Daisuke Tsukui, Hajime Kono
Summary: Hyperuricemia is associated with numerous diseases such as gout, hypertension, chronic kidney diseases, and cardiovascular diseases. Research has shown that intracellular uric acid production can lead to the generation of reactive oxygen species, which regulate intracellular signaling pathways and may contribute to the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Qian Wang, Dewei Peng, Bingyu Huang, Lintong Men, Tao Jiang, Shengqi Huo, Moran Wang, Junyi Guo, Jiagao Lv, Li Lin
Summary: It has been found that notopterol has a cardioprotective effect in hyperuricemic mice, improving exercise capacity and alleviating cardiac dysfunction. The mechanism involves the inhibition of the P2X7R/NLRP3 signaling pathway, suppressing inflammatory responses and pyroptosis. Notopterol could be a potential therapeutic strategy against hyperuricemia-induced cardiac damage.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
