Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-12-06
DOI
10.3389/fphar.2019.01469
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Effectiveness and Safety of Tripterygium wilfordii Hook. F Extracts in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
- (2018) Ying-Yan Zhou et al. Frontiers in Pharmacology
- Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
- (2017) Fei Han et al. International Journal of Biological Sciences
- Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy
- (2017) Xing-gang Dong et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Membranous nephropathy: integrating basic science into improved clinical management
- (2017) Daniel C. Cattran et al. KIDNEY INTERNATIONAL
- Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis
- (2016) G M Bell et al. ANNALS OF THE RHEUMATIC DISEASES
- Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts
- (2016) Chun Chen et al. CANCER BIOLOGY & THERAPY
- Triptolide Rescues Spatial Memory Deficits and Amyloid-? Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice
- (2016) Yan-Qiu Cui et al. Current Alzheimer Research
- Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy
- (2016) H. Guo et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway
- (2016) Yanlong Yang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy
- (2016) Xin Guo et al. JOURNAL OF ETHNOPHARMACOLOGY
- Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway
- (2016) Ying Zhou et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25–35-treated differentiated PC12 cells
- (2016) Pengjuan Xu et al. LIFE SCIENCES
- Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells
- (2016) Guanzheng Hu et al. MOLECULAR NEUROBIOLOGY
- Tipping the balance towards resolution
- (2016) Joanna Collison Nature Reviews Rheumatology
- Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer′s disease
- (2016) Jian-ming Li et al. Neural Regeneration Research
- Therapeutic effects of triptolide via the inhibition of IL-1β expression in a mouse model of ulcerative colitis
- (2016) Haifeng Zhang et al. Experimental and Therapeutic Medicine
- Triptolide improves systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats
- (2015) Zhongshu Liang et al. BMC Cardiovascular Disorders
- Triptolide inhibits TGF-β1-induced cell proliferation in rat airway smooth muscle cells by suppressing Smad signaling
- (2015) Ming Chen et al. EXPERIMENTAL CELL RESEARCH
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-қB activation and titanium particle-induced osteolysis in a mouse model
- (2015) Jianbin Huang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma
- (2015) Ming Chen et al. MOLECULAR IMMUNOLOGY
- Triptolide ameliorates colonic fibrosis in an experimental rat model
- (2015) QINGSONG TAO et al. Molecular Medicine Reports
- Understanding the mechanisms of kidney fibrosis
- (2015) Dong Zhou et al. Nature Reviews Nephrology
- Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis
- (2015) Shanmin Yang et al. RADIATION RESEARCH
- Inflammation in Parkinson’s disease: role of glucocorticoids
- (2015) MarÃa-Trinidad Herrero et al. Frontiers in Neuroanatomy
- Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25–35 via the Autophagy Pathway
- (2015) Pengjuan Xu et al. PLoS One
- Comparison ofTripterygium wilfordiiHook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial
- (2014) Qian-wen Lv et al. ANNALS OF THE RHEUMATIC DISEASES
- Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD
- (2014) Q. Wang et al. Disease Models & Mechanisms
- Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice
- (2014) H. Zhang et al. GENETICS AND MOLECULAR RESEARCH
- Anti-inflammatory Effects of Triptolide in LPS-Induced Acute Lung Injury in Mice
- (2014) Dong Wei et al. INFLAMMATION
- Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model
- (2014) XIAN WANG et al. Molecular Medicine Reports
- Triptolide Preserves Cognitive Function and Reduces Neuropathology in a Mouse Model of Alzheimer's Disease
- (2014) Shaowu Cheng et al. PLoS One
- Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy
- (2013) He-Ling Wen et al. Cardiovascular Diabetology
- Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway
- (2013) Chunfang Liu et al. Evidence-based Complementary and Alternative Medicine
- Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs
- (2013) SEUNG-WON PARK et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Triptolide-Conditioned Dendritic Cells Induce Allospecific T-Cell Regulation and Prolong Renal Graft Survival
- (2013) Gutian Zhang et al. JOURNAL OF INVESTIGATIVE SURGERY
- The Pathogenesis of Lupus Nephritis
- (2013) M. Lech et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory “Junn-Chenn-Zuou-SS”
- (2013) Ling-Jun Ho et al. Journal of Translational Medicine
- Inhibition of interleukin-13 gene expression by triptolide in activated T lymphocytes
- (2013) Shanlin Dai et al. RESPIROLOGY
- Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy
- (2013) RUIXIA MA et al. Experimental and Therapeutic Medicine
- Targeting monocytes/macrophages in the treatment of rheumatoid arthritis
- (2012) J.-L. Davignon et al. RHEUMATOLOGY
- Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
- (2011) Cris S Constantinescu et al. BRITISH JOURNAL OF PHARMACOLOGY
- The effects of triptolide on airway remodelling and transforming growth factor-β1/Smad signalling pathway in ovalbumin-sensitized mice
- (2011) Ming Chen et al. IMMUNOLOGY
- Antifibrotic Effects of Triptolide on Hepatic Stellate Cells and Dimethylnitrosamine-intoxicated Rats
- (2011) Lee-Won Chong et al. PHYTOTHERAPY RESEARCH
- Triptolide Down-regulates COX-2 Expression and PGE2 Release by Suppressing the Activity of NF-κB and MAP kinases in Lipopolysaccharide-treated PC12 Cells
- (2011) Yu Geng et al. PHYTOTHERAPY RESEARCH
- Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation
- (2010) Gary W. Hoyle et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro
- (2010) Zhao-Hong Chen et al. KIDNEY INTERNATIONAL
- Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17
- (2010) Yi Li et al. MOLECULAR IMMUNOLOGY
- Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction
- (2010) XIAO-PENG YUAN et al. NEPHROLOGY
- Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy
- (2010) Q. Gao et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
- (2009) Zhipeng Wang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
- (2009) Beatrix Bartok et al. IMMUNOLOGICAL REVIEWS
- Triptolide promotes generation of FoxP3+ T regulatory cells in rats
- (2009) Gutian Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex
- (2009) Pablo Kizelsztein et al. JOURNAL OF NEUROIMMUNOLOGY
- Dendritic cells as targets for therapy in rheumatoid arthritis
- (2009) Shaukat Khan et al. Nature Reviews Rheumatology
- Inflammatory Bowel Disease
- (2009) Clara Abraham et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: a study on induced arthritis in rats
- (2009) Cheng Xiao et al. Chinese Medicine
- Effective therapy for nephritis in (NZB × NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedyTripterygium wilfordii Hook F
- (2008) Xuelian Tao et al. ARTHRITIS AND RHEUMATISM
- The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 deficient mice
- (2008) Xiaowei Wei et al. CLINICAL IMMUNOLOGY
- Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts
- (2008) Y. Lu et al. INFLAMMATION RESEARCH
- Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis
- (2008) Hui Mao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives
- (2008) Florian Rieder et al. Journal of Crohns & Colitis
- Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis
- (2008) Ying Wang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The Role of Inflammatory Cytokines in Diabetic Nephropathy
- (2008) J. F. Navarro-Gonzalez et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mechanism of cellular rejection in transplantation
- (2008) Elizabeth Ingulli PEDIATRIC NEPHROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started