Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells

Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma

(2020) Gregory Lazarian et al.   ONCOGENE

Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer

(2020) Mariana Cooke et al.   Frontiers in Cell and Developmental Biology

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies

(2020) Dimitar G. Efremov et al.   Cancers

The Wnt Signalling Pathway: A Tailored Target in Cancer

(2020) Malvina Koni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Vav GEF Family: An Evolutionary and Functional Perspective

(2019) Sonia Rodríguez-Fdez et al.   Cells

Vav1 mutations: What makes them oncogenic?

(2019) Marganit Farago et al.   CELLULAR SIGNALLING

The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

(2019) Toufic Kassouf et al.   Cancers

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges

(2018) Xosé R. Bustelo   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk

(2018) Deepshikha Bhardwaj et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The effect of PU.1 knockdown on gene expression and function of mast cells

(2018) Yoshihito Oda et al.   Scientific Reports

Spleen tyrosine kinase SYK(L) interacts with YY1 and coordinately suppresses SNAI2 transcription in lung cancer cells

(2018) Dan Gao et al.   FEBS Journal

Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes

(2018) Batel Shalom et al.   Oncogenesis

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

(2017) Francesco Abate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy

(2017) Maximilien Cottat et al.   Scientific Reports

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers

(2016) De Pradip et al.   Oncotarget

Targeting Syk in Autoimmune Rheumatic Diseases

(2016) Guo-Min Deng et al.   Frontiers in Immunology

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

(2015) Mariya O. Krisenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion

(2015) G. L. Razidlo et al.   CANCER RESEARCH

Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion

(2015) Mireia Náger et al.   CELL CYCLE

p21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and β-Catenin/MITF Pathways

(2015) Cheong-Yong Yun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

How Does Multistep Tumorigenesis Really Proceed?

(2015) Christine L. Chaffer et al.   Cancer Discovery

Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer

(2015) Shulamit Katzav   Oncotarget

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion

(2015) Shulamit Sebban et al.   Oncotarget

Mutation of Vav1 adaptor region reveals a new oncogenic activation

(2015) Lyra Razanadrakoto et al.   Oncotarget

Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis

(2014) So-Hyun Shin et al.   LABORATORY INVESTIGATION

Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance

(2014) J C Lindsey et al.   ONCOGENE

SYK Allelic Loss and the Role of Syk-Regulated Genes in Breast Cancer Survival

(2014) Jan Blancato et al.   PLoS One

The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins

(2014) M. Barreira et al.   Science Signaling

Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer

(2013) Akshata R Udyavar et al.   BMC Systems Biology

Vav1 as a Central Regulator of Invadopodia Assembly

(2013) Gina L. Razidlo et al.   CURRENT BIOLOGY

Hypermethylation and prognostic implication of Syk gene in human colorectal cancer

(2013) Zuli Yang et al.   MEDICAL ONCOLOGY

VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer

(2013) Senn Wakahashi et al.   Translational Research

The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops

(2013) Mauricio Menacho-Márquez et al.   PLOS BIOLOGY

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

5-aza-CdR induces the demethylation of Syk promoter in nasopharyngeal carcinoma cell

(2012) Qiaozhi Jin et al.   GENE

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia

(2012) Y Xi et al.   ONCOGENE

The Rho Exchange Factors Vav2 and Vav3 Control a Lung Metastasis-Specific Transcriptional Program in Breast Cancer Cells

(2012) C. Citterio et al.   Science Signaling

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

The promoter methylation of the Syk gene in nasopharyngeal carcinoma cell lines

(2012) CHONG YAN et al.   Oncology Letters

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

(2011) G Zhu et al.   ONCOGENE

Oncogenic K-ras “addiction” and synthetic lethality

(2010) Anurag Singh et al.   CELL CYCLE

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

Research on the reactivation of Syk expression caused by the inhibition of DNA promoter methylation in the lung cancer

(2010) S. DONG et al.   NEOPLASMA

Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

(2010) B. Heizmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis

(2009) Galit Lazer et al.   JOURNAL OF PATHOLOGY

Mass Spectrometry-Based Identification of Y745 of Vav1 as a Tyrosine Residue Crucial in Maturation of Acute Promyelocytic Leukemia-Derived Cells

(2009) Valeria Bertagnolo et al.   JOURNAL OF PROTEOME RESEARCH

Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell–cell adhesion

(2009) R M Larive et al.   ONCOGENE

Tumor Suppressor Function of Syk in Human MCF10A In Vitro and Normal Mouse Mammary Epithelium In Vivo

(2009) You Me Sung et al.   PLoS One

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Flap Endonuclease 1 Contributes to Telomere Stability

(2008) Abhishek Saharia et al.   CURRENT BIOLOGY