The Wnt Signalling Pathway: A Tailored Target in Cancer

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

(2020) Yong-Hee Cho et al.   Cell Communication and Signaling

Down‐regulation of SLC35C1 induces colon cancer through over‐activating Wnt pathway

(2020) Minzi Deng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosome‐mediated transfer of miR‐1260b promotes cell invasion through Wnt/β–catenin signaling pathway in lung adenocarcinoma

(2020) Yang Xia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR‑552‑5p/FOXO3 axis

(2020) Tengxiang Chen et al.   ONCOLOGY REPORTS

miR106a Promotes the Growth of Transplanted Breast Cancer and Decreases the Sensitivity of Transplanted Tumors to Cisplatin

(2020) Faping You et al.   Cancer Management and Research

Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity

(2020) Donatella Lucchetti et al.   Cancers

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Loss of APC Rapidly Impairs DNA Methylation Programs and Cell Fate Decisions in LGR5+ Intestinal Stem Cells

(2020) Marco Bruschi et al.   CANCER RESEARCH

miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/β-catenin signaling

(2020) Naihui Sun et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing

(2020) Xidan Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR‐148a‐3p/WNT1 pathway

(2020) Li Han et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tetrandrine Reverses Paclitaxel Resistance in Human Ovarian Cancer via Inducing Apoptosis, Cell Cycle Arrest Through β-Catenin Pathway

(2020) Luo Jiang et al.   OncoTargets and Therapy

MicroRNA-939 Directly Targets HDGF to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway

(2020) Jie Situ et al.   OncoTargets and Therapy

KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway

(2020) Yi Song et al.   Cancer Management and Research

WNT Signaling in Melanoma

(2020) Anna Gajos-Michniewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2

(2020) Lifeng Huang et al.   PHARMACOLOGICAL RESEARCH

TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling

(2020) Xiumei Zhang et al.   OncoTargets and Therapy

Long Noncoding RNA FGD5-AS1 Promotes Glioma Cell Proliferation, Migration and Invasion by Regulating wnt/β-Catenin Pathway

(2020) Jun Bo Zhao et al.   Cancer Management and Research

MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

(2020) Ruizhen Wu et al.   Cancer Management and Research

Modeling the Diversity of Epithelial Ovarian Cancer through Ten Novel Well Characterized Cell Lines Covering Multiple Subtypes of the Disease

(2020) Alexandre Sauriol et al.   Cancers

Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors

(2020) Claudia Cavallari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming

(2020) Tatiana Lopatina et al.   Oncogenesis

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

(2019) Chunjie Xu et al.   Cell Death & Disease

Tegavivint and the β-catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma

(2019) Motonari Nomura et al.   JNCI-Journal of the National Cancer Institute

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway

(2019) Jinghui Hu et al.   Cancer Cell International

ALPL regulates the aggressive potential of high grade serous ovarian cancer cells via a non-canonical WNT pathway

(2019) Mu Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent advances in triple negative breast cancer: the immunotherapy era

(2019) Antonio Marra et al.   BMC Medicine

miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation

(2019) Mohamed Salem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA methylation and chromatin modifiers in colorectal cancer

(2019) Veronika Vymetalkova et al.   MOLECULAR ASPECTS OF MEDICINE

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

(2019) Liu Han et al.   Molecular Cancer

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors

(2019) Zsuzsanna Szvicsek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin

(2019) Honghong Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

(2019) Irantzu Gorroño-Etxebarria et al.   Cancers

Suppression of the proliferation and invasion of breast cancer cells by ST 7L occurs through inhibition of activation of Wnt/ GSK ‐3β/β‐catenin signalling

(2019) Hua Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Hypoxia-induced exosomes promote hepatocellular carcinoma proliferation and metastasis via miR-1273f transfer

(2019) You Yu et al.   EXPERIMENTAL CELL RESEARCH

Timeless-Stimulated miR-5188-FOXO1/β-Catenin-c-Jun Feedback Loop Promotes Stemness via Ubiquitination of β-Catenin in Breast Cancer

(2019) Yujiao Zou et al.   MOLECULAR THERAPY

Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer

(2019) Xiaohong Ruan et al.   Molecular Therapy-Oncolytics

HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/β-catenin signaling

(2019) Liang Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity

(2019) Sathya Muralidhar et al.   CANCER RESEARCH

MicroRNA‐520e targets AEG‐1 to suppress the proliferation and invasion of colorectal cancer cells through Wnt/GSK‐3β/β‐catenin signalling

(2019) Samei Lv et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

(2019) Hina Kalra et al.   Journal of Extracellular Vesicles

MiR‐6838‐5p suppresses cell metastasis and the EMT process in triple‐negative breast cancer by targeting WNT3A to inhibit the Wnt pathway

(2019) Guozhu Liu et al.   JOURNAL OF GENE MEDICINE

Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis

(2019) Vu Hong Loan Nguyen et al.   Journal of Ovarian Research

Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

(2019) Jia-Hong Chen et al.   Cancers

miRNA-590-3p promotes ovarian cancer growth and metastasis via a novel FOXA2-versican pathway

(2018) Mohamed Salem et al.   CANCER RESEARCH

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3

(2018) Lei Liu et al.   CANCER RESEARCH

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells

(2018) Zhiying Yue et al.   FASEB JOURNAL

Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling

(2018) Soohyun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling

(2018) Victoria H. Ng et al.   JOURNAL OF CELL SCIENCE

RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1

(2018) Mengmeng Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Wnt5a-induced cell migration is associated with the aggressiveness of estrogen receptor-positive breast cancer

(2018) Yoshie Kobayashi et al.   Oncotarget

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells

(2018) Oksana Voloshanenko et al.   Scientific Reports

Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma

(2018) Won-Sik Shin et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production

(2018) Feng-Wei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance

(2018) Y.-B. Hu et al.   ONCOGENE

Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts

(2018) Sylvia Faict et al.   Blood Cancer Journal

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

(2017) Masaru Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

PTK7 localization and protein stability is affected by canonical Wnt ligands

(2017) Hanna Berger et al.   JOURNAL OF CELL SCIENCE

miR-377-3p drives malignancy characteristics via upregulating GSK-3β expression and activating NF-κB pathway in hCRC cells

(2017) Wei-Ying Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer

(2017) Noritaka Tanaka et al.   MOLECULAR CANCER THERAPEUTICS

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway

(2017) Giusy Lombardo et al.   ONCOGENE

MicroRNAs and cancer: Key paradigms in molecular therapy (Review)

(2017) Weige Tan et al.   Oncology Letters

Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion

(2017) Chandra Prakash Prasad et al.   Oncotarget

Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer

(2017) Maria Chiara Proto et al.   Scientific Reports

Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway

(2016) Li Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

The Wnt signaling pathway in cancer

(2016) Yann Duchartre et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition

(2016) Chandra Prakash Prasad et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers

(2016) Abhishek Bhandari et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

(2016) Pu-Hyeon Cha et al.   Nature Chemical Biology

Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway

(2016) Rui Hou et al.   TUMOR BIOLOGY

TNIK inhibition abrogates colorectal cancer stemness

(2016) Mari Masuda et al.   Nature Communications

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

(2016) Tania M. Puvirajesinghe et al.   Nature Communications

Mammary Development and Breast Cancer: A Wnt Perspective

(2016) Qing Yu et al.   Cancers

Elevated β-catenin activity contributes to carboplatin resistance in A2780cp ovarian cancer cells

(2015) Samir H. Barghout et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells

(2015) N. Borcherding et al.   CANCER RESEARCH

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling

(2015) Lu Yang et al.   STEM CELLS

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

(2015) Anil Belur Nagaraj et al.   Oncotarget

MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

(2015) Geyan Wu et al.   Oncotarget

Subtyping of triple-negative breast cancer: Implications for therapy

(2014) Vandana G. Abramson et al.   CANCER

Safely targeting cancer stem cells via selective catenin coactivator antagonism

(2014) Heinz-Josef Lenz et al.   CANCER SCIENCE

Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/β-Catenin Signaling

(2014) Byoung-San Moon et al.   JNCI-Journal of the National Cancer Institute

14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway

(2014) Shiri Dovrat et al.   Molecular Oncology

FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway

(2014) M Asad et al.   Cell Death & Disease

The essential role of TNIK gene amplification in gastric cancer growth

(2014) D-H Yu et al.   Oncogenesis

Activation of Intracellular Calcium by Multiple Wnt Ligands and Translocation of β-Catenin into the Nucleus

(2013) Christopher Thrasivoulou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

WNT5A Encodes Two Isoforms with Distinct Functions in Cancers

(2013) Matthieu Bauer et al.   PLoS One

Wnt5a Inhibits Human Monocyte-Derived Myeloid Dendritic Cell Generation

(2013) C. Bergenfelz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients

(2012) C. Bergenfelz et al.   JOURNAL OF IMMUNOLOGY

ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma

(2012) Songtao Qi et al.   PLoS One

MicroRNA Genes and Their Target 3′-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers

(2012) Georgina L. Ryland et al.   PLoS One

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

Transcriptional Activation of ZEB1 by Slug Leads to Cooperative Regulation of the Epithelial–Mesenchymal Transition-Like Phenotype in Melanoma

(2011) Christian Wels et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Possible involvement of Wnt11 in colorectal cancer progression

(2011) Mitsuaki Nishioka et al.   MOLECULAR CARCINOGENESIS

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase

(2010) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast

(2010) Magali Lacroix-Triki et al.   MODERN PATHOLOGY

RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent Phosphorylation in Colon Cancer

(2010) Ji Min Lee et al.   MOLECULAR CELL

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways

(2009) Ivana Samarzija et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Multifaceted Role of MTDH/AEG-1 in Cancer Progression

(2009) G. Hu et al.   CLINICAL CANCER RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Competing Causes of Death for Women With Breast Cancer and Change Over Time From 1975 to 2003

(2008) Xianglin L. Du et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

MicroRNAs in Cancer

(2008) Yong Sun Lee et al.   Annual Review of Pathology-Mechanisms of Disease

The Wnt-5a-Derived Hexapeptide Foxy-5 Inhibits Breast Cancer Metastasis In vivo by Targeting Cell Motility

(2008) A. Safholm et al.   CLINICAL CANCER RESEARCH

Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase

(2008) Yan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus

(2008) J-W Jeong et al.   ONCOGENE