The many faces and functions of β-catenin

Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells

(2012) Bingnan Gu et al.   CELL CYCLE

Beta-Catenin Phosphorylated at Threonine 120 Antagonizes Generation of Active Beta-Catenin by Spatial Localization in trans-Golgi Network

(2012) Cheng Du et al.   PLoS One

How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway

(2011) H. C. Archbold et al.   Acta Physiologica

The evolutionary history of the catenin gene family during metazoan evolution

(2011) Zi-Ming Zhao et al.   BMC EVOLUTIONARY BIOLOGY

Unraveling the role of FoxOs in bone—Insights from mouse models

(2011) Maria Almeida   BONE

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

(2011) Eirini Trompouki et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism

(2011) Kevin F. Kelly et al.   Cell Stem Cell

Function and regulation of the Mediator complex

(2011) Ronald C Conaway et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin

(2011) N. Xin et al.   DEVELOPMENT

Phosphorylated β-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain

(2011) Dmitri Chilov et al.   DEVELOPMENTAL BIOLOGY

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

(2011) Fen Yang et al.   EMBO JOURNAL

Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity

(2011) Hassina Benchabane et al.   EMBO JOURNAL

The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets

(2011) Chandan Bhambhani et al.   EMBO JOURNAL

BCL9-2 Promotes Early Stages of Intestinal Tumor Progression

(2011) Felix H. Brembeck et al.   GASTROENTEROLOGY

Probing transcription-specific outputs of  -catenin in vivo

(2011) T. Valenta et al.   GENES & DEVELOPMENT

 -catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

(2011) W. van Veelen et al.   GUT

Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2

(2011) Hiroki Hikasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3 by Wnt signalling - two contrasting models

(2011) C. Metcalfe et al.   JOURNAL OF CELL SCIENCE

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

(2011) Natalia Lyashenko et al.   NATURE CELL BIOLOGY

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

(2011) Fei Yi et al.   NATURE CELL BIOLOGY

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin

(2011) Ivana Mirkovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

(2011) G Zhu et al.   ONCOGENE

Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

(2011) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Polarized Epithelium Organized by  - and  -Catenin Predates Cadherin and Metazoan Origins

(2011) D. J. Dickinson et al.   SCIENCE

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling

(2011) E. Eivers et al.   Science Signaling

Homeodomain-interacting protein kinase 2 (HIPK2) targets β-catenin for phosphorylation and proteasomal degradation

(2010) Eun-A Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas

(2010) J. Deka et al.   CANCER RESEARCH

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

(2010) Aaron J. Quyn et al.   Cell Stem Cell

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

(2010) C. Niehrs   DEVELOPMENT

β-catenin plays a central role in setting up the head organizer in hydra

(2010) Lydia Gee et al.   DEVELOPMENTAL BIOLOGY

Conductin/axin2 and Wnt signalling regulates centrosome cohesion

(2010) Michel V Hadjihannas et al.   EMBO REPORTS

Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

(2010) Maja Adamska et al.   EVOLUTION & DEVELOPMENT

Cross-regulation of signaling pathways: An example of nuclear hormone receptors and the canonical Wnt pathway

(2010) Marcy E. Beildeck et al.   EXPERIMENTAL CELL RESEARCH

Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling

(2010) H. Song et al.   GENES & DEVELOPMENT

Requirement of TCF7L2 for TGF-β-dependent Transcriptional Activation of the TMEPAI Gene

(2010) Naoko Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Ubiquitination of β-Catenin by Siah-1 and Regulation by the Exchange Factor TBL1

(2010) Yoana N. Dimitrova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion

(2010) Jacqueline M. Benjamin et al.   JOURNAL OF CELL BIOLOGY

Upregulation of c-MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells

(2010) J. B. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

O2 regulates stem cells through Wnt/β-catenin signalling

(2010) Jolly Mazumdar et al.   NATURE CELL BIOLOGY

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

(2010) Daniel Bottomly et al.   NUCLEIC ACIDS RESEARCH

TWISTing an embryonic transcription factor into an oncoprotein

(2010) S Ansieau et al.   ONCOGENE

Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression

(2010) Ryan T. Wagner et al.   STEM CELLS

A Re-evaluation of the “Oncogenic” Nature of Wnt/β-catenin Signaling in Melanoma and Other Cancers

(2010) Olivia M. Lucero et al.   Current Oncology Reports

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

(2009) Laura Arce et al.   BMC CANCER

BCL9 Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic, and Angiogenic Properties to Cancer Cells

(2009) M. Mani et al.   CANCER RESEARCH

Protein Kinase D1-Mediated Phosphorylation and Subcellular Localization of  -Catenin

(2009) C. Du et al.   CANCER RESEARCH

Wnt Signaling and the Polarity of the Primary Body Axis

(2009) Christian P. Petersen et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

(2009) Rocio Sancho et al.   EMBO JOURNAL

The kinase TNIK is an essential activator of Wnt target genes

(2009) Tokameh Mahmoudi et al.   EMBO JOURNAL

The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway

(2009) Haiyun Song et al.   EMBO REPORTS

Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

(2009) Ser Sue Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

(2009) Bingnan Gu et al.   JOURNAL OF CELL BIOLOGY

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The PHD domain is required to link Drosophila Pygopus to Legless/β-catenin and not to histone H3

(2009) Roman Kessler et al.   MECHANISMS OF DEVELOPMENT

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

WNT/β-Catenin Signalling and Epithelial Patterning in the Homoscleromorph Sponge Oscarella

(2009) Pascal Lapébie et al.   PLoS One

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adherens Junction: Molecular Architecture and Regulation

(2009) W. Meng et al.   Cold Spring Harbor Perspectives in Biology

Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development

(2009) E. Stepniak et al.   Cold Spring Harbor Perspectives in Biology

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells

(2008) Marc de la Roche et al.   BMC CANCER

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

(2008) Tianru Jin et al.   CELLULAR SIGNALLING

Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF

(2008) Mikyung V. Chang et al.   CURRENT BIOLOGY

Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of  -catenin/Arm and stimulation of target gene expression

(2008) W. Lee et al.   DEVELOPMENT

Regulation of the feedback antagonist naked cuticle by Wingless signaling

(2008) Jinhee L. Chang et al.   DEVELOPMENTAL BIOLOGY

The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets

(2008) Yan I. Liu et al.   DEVELOPMENTAL BIOLOGY

The C. elegans SYS-1 Protein Is a Bona Fide β-Catenin

(2008) Jing Liu et al.   DEVELOPMENTAL CELL

O-GlcNAc-glycosylation of β-catenin regulates its nuclear localization and transcriptional activity

(2008) Ria Sayat et al.   EXPERIMENTAL CELL RESEARCH

Regulation of Wnt Signaling by the Nuclear Pore Complex

(2008) Miki Shitashige et al.   GASTROENTEROLOGY

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the β-Catenin-TCF4 Complex

(2008) Liang-Nian Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity

(2008) Feng-Qian Li et al.   JOURNAL OF CELL BIOLOGY

p38 mitogen-activated protein kinase regulates canonical Wnt- -catenin signaling by inactivation of GSK3 

(2008) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Cell-Type-Specific Function of BCL9 Involves a Transcriptional Activation Domain That Synergizes with  -Catenin

(2008) C. Sustmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex

(2008) Marc Fiedler et al.   MOLECULAR CELL

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY

Snail promotes Wnt target gene expression and interacts with β-catenin

(2008) V Stemmer et al.   ONCOGENE

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription

(2008) J. Mieszczanek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

(2008) I. Carrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE

The first five years of the Wnt targetome

(2007) Annica Vlad et al.   CELLULAR SIGNALLING

-Catenin is a Nek2 substrate involved in centrosome separation

(2007) S. Bahmanyar et al.   GENES & DEVELOPMENT