RHO GTPases in cancer: known facts, open questions, and therapeutic challenges
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
RHO GTPases in cancer: known facts, open questions, and therapeutic challenges
Authors
Keywords
-
Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 46, Issue 3, Pages 741-760
Publisher
Portland Press Ltd.
Online
2018-06-05
DOI
10.1042/bst20170531
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
- (2018) Jose R. Cortes et al. CANCER CELL
- Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
- (2018) Rona Yaeger et al. CANCER CELL
- Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers
- (2017) Soo Young Cho et al. GASTROENTEROLOGY
- In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2 ) in ErbB2 (Neu ) oncogene induced mouse mammary tumors
- (2017) Pratima Basak et al. GENES CHROMOSOMES & CANCER
- Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response
- (2017) Daniel Reimer et al. INTERNATIONAL JOURNAL OF CANCER
- Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis
- (2017) Shengbing Zang et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma
- (2017) M Fujisawa et al. LEUKEMIA
- PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
- (2017) Hezhe Lu et al. NATURE
- Whole-genome landscapes of major melanoma subtypes
- (2017) Nicholas K. Hayward et al. NATURE
- Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
- (2017) Sjors M Kas et al. NATURE GENETICS
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
- (2017) Ahmet Zehir et al. NATURE MEDICINE
- Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
- (2017) A García-Mariscal et al. ONCOGENE
- SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression
- (2017) P Gonyo et al. ONCOGENE
- Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas
- (2017) Francesco Abate et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
- (2017) Jiqiu Cheng et al. Nature Communications
- Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies
- (2017) Emmet J. Jordan et al. Cancer Discovery
- Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
- (2017) Yelena Y. Janjigian et al. Cancer Discovery
- Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo
- (2017) Yun-Ju Lai et al. Oncotarget
- The Functional Impact of Alternative Splicing in Cancer
- (2017) Héctor Climente-González et al. Cell Reports
- 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
- (2017) Jianjiong Gao et al. Genome Medicine
- The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers
- (2017) Luc G. T. Morris et al. JAMA Oncology
- Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma
- (2016) R. L. Boddicker et al. BLOOD
- Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas
- (2016) D. Vallois et al. BLOOD
- Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration
- (2016) Fabien Binamé et al. JOURNAL OF CELL BIOLOGY
- Comprehensive mutation profiling of mucinous gastric carcinoma
- (2016) Hirofumi Rokutan et al. JOURNAL OF PATHOLOGY
- Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
- (2016) Amro Aboukameel et al. MOLECULAR CANCER THERAPEUTICS
- Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- (2016) Serena Nik-Zainal et al. NATURE
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
- (2016) Joshua D Campbell et al. NATURE GENETICS
- Unsupervised detection of cancer driver mutations with parsimony-guided learning
- (2016) Runjun D Kumar et al. NATURE GENETICS
- Regulating Rho GTPases and their regulators
- (2016) Richard G. Hodge et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ROCK2/ras Ha co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression
- (2016) S F Masre et al. ONCOGENE
- Rho GTPases: Anti- or pro-neoplastic targets?
- (2016) I Zandvakili et al. ONCOGENE
- Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation
- (2016) Antonio Castro-Castro et al. PLoS One
- Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
- (2016) Yonathan Lissanu Deribe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
- (2016) Jieqiong Wang et al. Nature Communications
- A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression
- (2016) Victoria Casado-Medrano et al. Oncotarget
- Variegated RHOA mutations in adult T-cell leukemia/lymphoma
- (2015) Y. Nagata et al. BLOOD
- Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1
- (2015) Jun Rao et al. CANCER LETTERS
- The Molecular Taxonomy of Primary Prostate Cancer
- (2015) Adam Abeshouse et al. CELL
- Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
- (2015) Giovanni Ciriello et al. CELL
- Approaches of targeting Rho GTPases in cancer drug discovery
- (2015) Yuan Lin et al. Expert Opinion on Drug Discovery
- Whole genomes redefine the mutational landscape of pancreatic cancer
- (2015) Nicola Waddell et al. NATURE
- Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
- (2015) Matthew T Chang et al. NATURE BIOTECHNOLOGY
- Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway
- (2015) A Hunter Shain et al. NATURE GENETICS
- Integrated molecular analysis of adult T cell leukemia/lymphoma
- (2015) Keisuke Kataoka et al. NATURE GENETICS
- A role for Rac1 activity in malignant progression of sebaceous skin tumors
- (2015) D Frances et al. ONCOGENE
- RAC1 P29S regulates PD-L1 expression in melanoma
- (2015) Ha Linh Vu et al. Pigment Cell & Melanoma Research
- Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice
- (2015) Inuk Zandvakili et al. PLoS One
- Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2
- (2015) Marta E. Capala et al. PLoS One
- Genomic alterations inBCL2L1andDLC1contribute to drug sensitivity in gastric cancer
- (2015) Hansoo Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
- (2015) Helen J. Whalley et al. Nature Communications
- Regulation and functional significance of CDC42 alternative splicing in ovarian cancer
- (2015) Xiaolong He et al. Oncotarget
- Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma
- (2015) Mary Anne Conti et al. Scientific Reports
- Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
- (2014) S. W. Hofbauer et al. BLOOD
- The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1
- (2014) Jane Cullis et al. CANCER CELL
- CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
- (2014) R. Sakamori et al. CANCER RESEARCH
- The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
- (2014) Ian R. Watson et al. CANCER RESEARCH
- Arhgef7 promotes activation of the Hippo pathway core kinase Lats
- (2014) Emad Heidary Arash et al. EMBO JOURNAL
- PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
- (2014) Chia-Yen C. Wu et al. GASTROENTEROLOGY
- Comprehensive molecular characterization of gastric adenocarcinoma
- (2014) Adam J. Bass et al. NATURE
- Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
- (2014) Miwako Kakiuchi et al. NATURE GENETICS
- A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma
- (2014) Hae Yong Yoo et al. NATURE GENETICS
- Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
- (2014) Mamiko Sakata-Yanagimoto et al. NATURE GENETICS
- Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
- (2014) Kai Wang et al. NATURE GENETICS
- Downregulation of ROCK2 through Nanocomplex Sensitizes the Cytotoxic Effect of Temozolomide in U251 Glioma Cells
- (2014) Xiaojun Wen et al. PLoS One
- RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3
- (2014) Mozaffarul Islam et al. PLoS One
- Arhgap36-dependent activation of Gli transcription factors
- (2014) P. G. Rack et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas
- (2014) D. Schramek et al. SCIENCE
- RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
- (2014) Paulo Rodrigues et al. Nature Communications
- Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
- (2014) E. M. Van Allen et al. Cancer Discovery
- Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation
- (2014) Jianghong Man et al. Cell Reports
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
- (2014) Glenn S Cowley et al. Scientific Data
- RNA-aptamers that modulate the RhoGEF activity of Tiam1
- (2013) Björn Niebel et al. BIOORGANIC & MEDICINAL CHEMISTRY
- GAP-independent functions of DLC1 in metastasis
- (2013) David Barras et al. CANCER AND METASTASIS REVIEWS
- Pak1 Kinase Links ErbB2 to -Catenin in Transformation of Breast Epithelial Cells
- (2013) L. E. Arias-Romero et al. CANCER RESEARCH
- RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
- (2013) Ralph Fritsch et al. CELL
- A new signaling paradigm to control the prenylation and trafficking of small GTPases
- (2013) Carol Williams CELL CYCLE
- ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
- (2013) Kevin B. Myant et al. Cell Stem Cell
- PAK1 Mediates Resistance to PI3K Inhibition in Lymphomas
- (2013) K. Walsh et al. CLINICAL CANCER RESEARCH
- The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes
- (2013) M. D. David et al. JOURNAL OF CELL SCIENCE
- Pak and Rac GTPases promote oncogenic KIT–induced neoplasms
- (2013) Holly Martin et al. JOURNAL OF CLINICAL INVESTIGATION
- Constitutive Rac Activation Is Not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression
- (2013) Lucy E. Dalton et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- RhoB Promotes Cancer Initiation by Protecting Keratinocytes from UVB-Induced Apoptosis but Limits Tumor Aggressiveness
- (2013) Nicolas Meyer et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
- (2013) Guangwu Guo et al. NATURE GENETICS
- Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models
- (2013) T W Chew et al. ONCOGENE
- Tiam1 Transgenic Mice Display Increased Tumor Invasive and Metastatic Potential of Colorectal Cancer after 1,2-Dimethylhydrazine Treatment
- (2013) Li-Na Yu et al. PLoS One
- XPLN is an endogenous inhibitor of mTORC2
- (2013) N. Khanna et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
- (2013) X. Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transforming mutations of RAC guanosine triphosphatases in human cancers
- (2013) M. Kawazu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RAC1P29S is a spontaneously activating cancer-associated GTPase
- (2013) M. J. Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops
- (2013) Mauricio Menacho-Márquez et al. PLOS BIOLOGY
- Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival
- (2012) K. H. Chang et al. BLOOD
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
- (2012) Nicola Rath et al. EMBO REPORTS
- Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
- (2012) I Tala et al. LEUKEMIA
- Recurrent R-spondin fusions in colon cancer
- (2012) Somasekar Seshagiri et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Melanoma genome sequencing reveals frequent PREX2 mutations
- (2012) Michael F. Berger et al. NATURE
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
- (2012) C Zhou et al. ONCOGENE
- The Role of Dlc1 Isoform 2 in K-Ras2G12D Induced Thymic Cancer
- (2012) Mohammad Golam Sabbir et al. PLoS One
- RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells
- (2012) Devin T. Rosenthal et al. PLoS One
- The Rho Exchange Factors Vav2 and Vav3 Control a Lung Metastasis-Specific Transcriptional Program in Breast Cancer Cells
- (2012) C. Citterio et al. Science Signaling
- Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression
- (2012) M. L. Stallings-Mann et al. Science Translational Medicine
- Rho GTPase regulation by miRNAs and covalent modifications
- (2012) Ming Liu et al. TRENDS IN CELL BIOLOGY
- Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
- (2011) B. Mizukawa et al. BLOOD
- Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
- (2011) Michael S. Samuel et al. CANCER CELL
- Signaling circuitries controlling stem cell fate: to be or not to be
- (2011) Ramiro Iglesias-Bartolome et al. CURRENT OPINION IN CELL BIOLOGY
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation
- (2011) Antonio Castro-Castro et al. EMBO JOURNAL
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
- (2011) S Rao et al. ONCOGENE
- K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity
- (2011) Michael S. Samuel et al. PLoS One
- Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity
- (2011) Shailaja Akunuru et al. PLoS One
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- (2011) N. Stransky et al. SCIENCE
- P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
- (2011) Colin R. Lindsay et al. Nature Communications
- Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo
- (2010) A. Sengupta et al. BLOOD
- Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression
- (2010) Simon A. Woodcock et al. CURRENT BIOLOGY
- Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors
- (2010) C. M. Robbins et al. GENOME RESEARCH
- The role of Rho protein signaling in hypertension
- (2010) Gervaise Loirand et al. Nature Reviews Cardiology
- Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
- (2010) Z Wang et al. ONCOGENE
- Activating ROCK1 somatic mutations in human cancer
- (2010) P A Lochhead et al. ONCOGENE
- Rho GTPases in hematopoiesis and hemopathies
- (2009) J. C. Mulloy et al. BLOOD
- Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat
- (2009) Nathalie Bouquier et al. CHEMISTRY & BIOLOGY
- The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+mice
- (2009) Yoshihiro Kawasaki et al. EMBO REPORTS
- The Rho/Rac exchange factor Vav2 controls nitric oxide–dependent responses in mouse vascular smooth muscle cells
- (2009) Vincent Sauzeau et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
- (2009) B. Fine et al. SCIENCE
- Continuous Cell Injury Promotes Hepatic Tumorigenesis in Cdc42-Deficient Mouse Liver
- (2008) Jolanda van Hengel et al. GASTROENTEROLOGY
- Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice
- (2008) K. Strumane et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Scaffolding function of PAK in the PDK1–Akt pathway
- (2008) Maiko Higuchi et al. NATURE CELL BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now