Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

(2019) Carlos J Diaz Osterman et al.   eLife

Click Chemistry in Sphingolipid Research

(2018) Eduardo Izquierdo et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5

(2018) Benjamin Newcomb et al.   JOURNAL OF LIPID RESEARCH

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7

(2018) Svenja Bockelmann et al.   JOURNAL OF LIPID RESEARCH

LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling

(2018) Shanyi Zhang et al.   Cell Death & Disease

Visualizing Bioactive Ceramides

(2018) Daniel Canals et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Flux analysis reveals regulation of the sphingolipid network by doxorubicin in breast cancer cells

(2018) Justin M. Snider et al.   JOURNAL OF LIPID RESEARCH

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Research Techniques Made Simple: Analysis of Collective Cell Migration Using the Wound Healing Assay

(2017) Ayman Grada et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

(2017) George S. Karagiannis et al.   Science Translational Medicine

DiffSLC: A graph centrality method to detect essential proteins of a protein-protein interaction network

(2017) Divya Mistry et al.   PLoS One

Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence

(2016) Yan Li et al.   BMC CANCER

Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility

(2016) S. R. Piccolo et al.   Molecular Systems Biology

The Comparative Toxicogenomics Database: update 2017

(2016) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells

(2015) Ebtihal H Mustafa et al.   Asian Pacific Journal of Cancer Prevention

Ceramide and sphingosine in pulmonary infections

(2015) Aaron P. Seitz et al.   BIOLOGICAL CHEMISTRY

Acid Sphingomyelinase–Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

(2015) Melissa A. Lopes Pinheiro et al.   JOURNAL OF IMMUNOLOGY

Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy

(2015) Jenny Jaramillo-Gómez et al.   NEUROSCIENCE LETTERS

KEGG as a reference resource for gene and protein annotation

(2015) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance

(2013) J. M. L. Roodhart et al.   BLOOD

Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1

(2013) Zhaokang Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A tutorial in displaying mass spectrometry-based proteomic data using heat maps

(2012) Melissa Key   BMC BIOINFORMATICS

graphite - a Bioconductor package to convert pathway topology to gene network

(2012) Gabriele Sales et al.   BMC BIOINFORMATICS

Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation

(2012) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice

(2012) Jimmy Rotolo et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular simulation of rapid translocation of cholesterol, diacylglycerol, and ceramide in model raft and nonraft membranes

(2012) W. F. Drew Bennett et al.   JOURNAL OF LIPID RESEARCH

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

(2012) Karin Breuer et al.   NUCLEIC ACIDS RESEARCH

Identification of C6-ceramide-interacting proteins in D6P2T Schwannoma cells

(2012) Venkatesh Kota et al.   PROTEOMICS

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

(2011) Daniel Canals et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NumPy Array: A Structure for Efficient Numerical Computation

(2011) Stéfan van der Walt et al.   COMPUTING IN SCIENCE & ENGINEERING

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

(2011) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide channels and their role in mitochondria-mediated apoptosis

(2010) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane

(2010) Delphine Milhas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells

(2010) Amélie Rebillard et al.   EUROPEAN JOURNAL OF CANCER

Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation

(2010) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomic Analysis Reveals the Perturbation of Multiple Cellular Pathways in Jurkat-T Cells Induced by Doxorubicin

(2010) Xiaoli Dong et al.   JOURNAL OF PROTEOME RESEARCH

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

A role for ceramide in driving cancer cell resistance to doxorubicin

(2008) Yong-Yu Liu et al.   FASEB JOURNAL

Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity

(2008) Daria A. Chudakova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

(2008) Youssef H. Zeidan et al.   JOURNAL OF CELL BIOLOGY

Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development

(2008) Guanghu Wang et al.   JOURNAL OF NEUROCHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY