Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities
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Title
Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 14, Pages 3436
Publisher
MDPI AG
Online
2019-07-12
DOI
10.3390/ijms20143436
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Note: Only part of the references are listed.- Atg2 mediates direct lipid transfer between membranes for autophagosome formation
- (2019) Takuo Osawa et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Co-delivery of Doxorubicin and Ceramide in a Liposomal Formulation Enhances Cytotoxicity in Murine B16BL6 Melanoma Cell Lines
- (2019) Li Chen et al. AAPS PHARMSCITECH
- Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-kB-dependent P-glycoprotein upregulation
- (2019) Su-Fern Tan et al. JOURNAL OF LIPID RESEARCH
- Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- (2018) Mario Mauthe et al. Autophagy
- Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and β1 integrin/FAK−mediated signalling
- (2018) Marko Klobučar et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Autophagosome Formation: Cutting the Gordian Knot at the ER
- (2018) Bhawana Bissa et al. CURRENT BIOLOGY
- Expression of autophagy-related markers at the surgical margin of oral squamous cell carcinoma correlates with poor prognosis and tumor recurrence
- (2018) Takehito Terabe et al. HUMAN PATHOLOGY
- Role of sphingolipids in senescence: implication in aging and age-related diseases
- (2018) Magali Trayssac et al. JOURNAL OF CLINICAL INVESTIGATION
- New therapeutic strategies to treat human cancers expressing mutant p53 proteins
- (2018) Giovanni Blandino et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges
- (2018) Ha Nguyen et al. Pharmaceutics
- Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells
- (2018) Justine Leclerc et al. ONCOGENE
- Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur
- (2018) Alexey Dementiev et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting the sphingosine 1-phosphate axis exerts potent antitumor activity in BRAFi-resistant melanomas
- (2018) David Garandeau et al. MOLECULAR CANCER THERAPEUTICS
- Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics
- (2017) Anna Chiara Nascimbeni et al. FEBS Journal
- Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells
- (2017) Jose Antonio Ortega et al. JOURNAL OF MEDICINAL CHEMISTRY
- Emerging roles of lipid metabolism in cancer metastasis
- (2017) Xiangjian Luo et al. Molecular Cancer
- Targeted agents and immunotherapies: optimizing outcomes in melanoma
- (2017) Jason J. Luke et al. Nature Reviews Clinical Oncology
- Sphingolipids and their metabolism in physiology and disease
- (2017) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Acid ceramidase confers radioresistance to glioblastoma cells
- (2017) Ninh B. Doan et al. ONCOLOGY REPORTS
- BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy
- (2017) Douglas B. Johnson et al. Pigment Cell & Melanoma Research
- Acid ceramidase is a novel drug target for pediatric brain tumors
- (2017) Ninh B. Doan et al. Oncotarget
- Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency
- (2017) Ninh B. Doan et al. Oncotarget
- The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck
- (2017) et al. Genes
- Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells
- (2017) Michele Lai et al. Scientific Reports
- Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy
- (2016) Bing Liang et al. BIOMEDICINE & PHARMACOTHERAPY
- Recent insights into the function of autophagy in cancer: Table 1.
- (2016) Ravi Amaravadi et al. GENES & DEVELOPMENT
- Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma
- (2015) D. C. Gibbs et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Acid Ceramidase in Melanoma
- (2015) Natalia Realini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure–Activity Relationship (SAR) Studies
- (2015) Anders Bach et al. JOURNAL OF MEDICINAL CHEMISTRY
- Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance
- (2015) Xiao Su et al. Nanomedicine
- A Biomimic Reconstituted High-Density-Lipoprotein-Based Drug and p53 Gene Co-delivery System for Effective Antiangiogenesis Therapy of Bladder Cancer
- (2015) Qiaohong Ouyang et al. Nanoscale Research Letters
- A Biomimic Reconstituted High-Density-Lipoprotein-Based Drug and p53 Gene Co-delivery System for Effective Antiangiogenesis Therapy of Bladder Cancer
- (2015) Qiaohong Ouyang et al. Nanoscale Research Letters
- Sphingosine-1-Phosphate Promotes Extravillous Trophoblast Cell Invasion by Activating MEK/ERK/MMP-2 Signaling Pathways via S1P/S1PR1 Axis Activation
- (2014) Weiwei Yang et al. PLoS One
- Endocytosis and Autophagy: Exploitation or Cooperation?
- (2014) S. A. Tooze et al. Cold Spring Harbor Perspectives in Biology
- Correlation of Altered Expression of the Autophagy Marker LC3B with Poor Prognosis in Astrocytoma
- (2014) Daniel Winardi et al. Biomed Research International
- Sphingolipids in colon cancer
- (2013) Mónica García-Barros et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Autophagy paradox and ceramide
- (2013) Wenhui Jiang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- A current perspective of autophagosome biogenesis
- (2013) Shusaku T Shibutani et al. CELL RESEARCH
- Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
- (2013) Ikuko Maejima et al. EMBO JOURNAL
- Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1
- (2013) Jacob M. Gump et al. NATURE CELL BIOLOGY
- Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
- (2013) Natalia Realini et al. Scientific Reports
- Regulation of Autophagy by Sphingolipids
- (2012) Carmen Bedia et al. Anti-Cancer Agents in Medicinal Chemistry
- Ceramide stress in survival versus lethal autophagy paradox
- (2012) Wenhui Jiang et al. Autophagy
- MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN
- (2012) Li-Yi Zhang et al. CARCINOGENESIS
- Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”
- (2012) Makoto Taniguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingolipids: regulators of crosstalk between apoptosis and autophagy
- (2012) Megan M. Young et al. JOURNAL OF LIPID RESEARCH
- Autophagy in clear cell ovarian cancer, a potential marker for hypoxia and poor prognosis?#
- (2012) Spencer B Gibson JOURNAL OF PATHOLOGY
- MAP Kinase Pathways
- (2012) D. K. Morrison Cold Spring Harbor Perspectives in Biology
- Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine
- (2011) Carmen Bedia et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Many Ceramides
- (2011) Yusuf A. Hannun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
- (2010) N Walsh et al. BRITISH JOURNAL OF CANCER
- Ceramide Produces Apoptosis Through Induction of p27kip1by Protein Phosphatase 2A-dependent Akt Dephosphorylation in PC-3 Prostate Cancer Cells
- (2010) Sang Woo Kim et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide
- (2010) L S Turner et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Epidemiology of invasive cutaneous melanoma
- (2009) R. M. MacKie et al. ANNALS OF ONCOLOGY
- Genetic risk factors for melanoma
- (2009) Kathrine Damm Meyle et al. HUMAN GENETICS
- The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado
- (2009) Ashley L. Juhl et al. MELANOMA RESEARCH
- ABCB8 Mediates Doxorubicin Resistance in Melanoma Cells by Protecting the Mitochondrial Genome
- (2009) Aaron M. Elliott et al. MOLECULAR CANCER RESEARCH
- BrafV600E cooperates with Pten loss to induce metastatic melanoma
- (2009) David Dankort et al. NATURE GENETICS
- Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
- (2008) C MAO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma
- (2008) Z.-B. Ding et al. CANCER RESEARCH
- Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer
- (2008) Ayman EM Mahdy et al. MOLECULAR THERAPY
- Principles of bioactive lipid signalling: lessons from sphingolipids
- (2008) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Multidrug Transporter P-Glycoprotein: A Mediator of Melanoma Invasion?
- (2007) Marisa Colone et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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