Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

(2014) Amy V Paschall et al.   BMC CANCER

Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

(2014) Jin Cheng et al.   Molecular Oncology

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

(2014) E Kavanagh et al.   Cell Death & Disease

Role of cathepsin B in dengue virus-mediated apoptosis

(2013) Atthapan Morchang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio- and chemoresistance by inhibition of the anti-apoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large

(2013) Claudia Friesen et al.   EUROPEAN JOURNAL OF CANCER

Acid ceramidase as a therapeutic target in metastatic prostate cancer

(2013) Luz Camacho et al.   JOURNAL OF LIPID RESEARCH

Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling

(2013) Thomas H. Beckham et al.   PLoS One

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

(2013) M Granato et al.   Cell Death & Disease

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

(2013) J-Y Yoon et al.   Blood Cancer Journal

Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling

(2013) T H Beckham et al.   Oncogenesis

TGF-β Signaling, Activated Stromal Fibroblasts, and Cysteine Cathepsins B and L Drive the Invasive Growth of Human Melanoma Cells

(2012) Miao Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma

(2012) Hong Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

(2012) Chiara Ullio et al.   JOURNAL OF LIPID RESEARCH

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway

(2012) V R Gogineni et al.   Cell Death & Disease

Lysosomes and lysosomal cathepsins in cell death

(2011) Urška Repnik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma

(2011) V Cheriyath et al.   BRITISH JOURNAL OF CANCER

Doxorubicin-induced cell death requires cathepsin B in HeLa cells

(2010) S. Bien et al.   BIOCHEMICAL PHARMACOLOGY

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity

(2010) Min Luo et al.   CELL RESEARCH

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Cathepsin B-mediated Autophagy Flux Facilitates the Anthrax Toxin Receptor 2-mediated Delivery of Anthrax Lethal Factor into the Cytoplasm

(2009) Soon-Duck Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal ceramide mediates gemcitabine-induced death of glioma cells

(2009) Claudia A. Dumitru et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interaction with XIAP prevents full caspase‐3/‐7 activation in proliferating human T lymphocytes

(2008) Maren Paulsen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY