Journal
JOURNAL OF LIPID RESEARCH
Volume 60, Issue 5, Pages 913-918Publisher
ELSEVIER
DOI: 10.1194/jlr.S092874
Keywords
lipid signaling; lipidomics; membrane; fluidity; receptors; plasma membrane; animal models; cancer; aging; obesity; heart disease; multiple sclerosis
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Funding
- National Institutes of Health [GM062887, P01CA097132]
- Veterans Affairs Merit Award
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Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins. Advances over the past decade have improved our understanding of ceramide as a bioactive lipid. Generation and characterization of ceramide-metabolizing enzyme KO mice, development of specific inhibitors and ceramide-specific antibodies, use of advanced microscopy and mass spectrometry, and design of synthetic ceramide derivatives have all provided insight into the signaling mechanisms of ceramide and its implications in disease. As a result, the role of ceramide in biological functions and disease are now better understood, with promise for development of therapeutic strategies to treat ceramide-regulated diseases.
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