Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer

Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system

(2016) K Wang et al.   Cell Death & Disease

Lipidome in colorectal cancer

(2016) Guifang Yan et al.   Oncotarget

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

(2016) Mette M. B. Nielsen et al.   Scientific Reports

Tumor suppressive functions of ceramide: evidence and mechanisms

(2015) Sehamuddin Galadari et al.   APOPTOSIS

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

(2015) M Taniguchi et al.   Cell Death & Disease

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

(2015) Leonhard X. Heinz et al.   Cell Reports

Sphingomyelin Synthase 2, but Not Sphingomyelin Synthase 1, Is Involved in HIV-1 Envelope-mediated Membrane Fusion

(2014) Yasuhiro Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

(2014) Emilie Degagné et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Colonic Tumorigenesis in Alkaline Sphingomyelinase (NPP7) Knockout Mice

(2014) Y. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Sphingolipids in colon cancer

(2013) Mónica García-Barros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders

(2013) Makoto Taniguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice

(2012) L. Dong et al.   INTERNATIONAL IMMUNOLOGY

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

(2012) Joel D. Schilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-Related Inflammation

(2012) Juliana Candido et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice

(2012) Mei-Hong Lu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway

(2012) S. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

p38  and p38  kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

(2012) A. Risco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

The effect of sphingomyelin synthase 2 (SMS2) deficiency on the expression of drug transporters in mouse brain

(2011) Yu Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Sphingolipids in cancer

(2011) Hideki Furuya et al.   CANCER AND METASTASIS REVIEWS

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

(2011) Susumu Mitsutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation

(2011) Abo Bakr Abdel Shakor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury

(2010) Satish Gowda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis

(2010) Yifan Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis

(2010) A. Fischbeck et al.   GUT

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

(2009) Jacqueline Bromberg et al.   CANCER CELL

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

(2009) Jing Liu et al.   CIRCULATION RESEARCH

Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis

(2009) Annika Braun et al.   INFLAMMATORY BOWEL DISEASES

New insights into the aetiology of colorectal cancer from genome-wide association studies

(2009) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Lipid Alterations in Experimental Murine Colitis: Role of Ceramide and Imipramine for Matrix Metalloproteinase-1 Expression

(2009) Jessica Bauer et al.   PLoS One

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

(2008) Ashley J. Snider et al.   FASEB JOURNAL

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

(2008) Peter Laszlo Lakatos et al.   WORLD JOURNAL OF GASTROENTEROLOGY