Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems

Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative

(2021) Anna Zettergren et al.   Alzheimers Research & Therapy

Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease

(2021) Yu-Hui Liu et al.   Science Advances

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

(2021) Jeremy Schwartzentruber et al.   NATURE GENETICS

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

The most prevalent rare coding variants of TREM2 conferring risk of Alzheimer's disease: A systematic review and meta‑analysis

(2021) Rong Li et al.   Experimental and Therapeutic Medicine

Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

(2021) Gloriia Novikova et al.   Nature Communications

Whole‐genome sequencing reveals new Alzheimer's disease–associated rare variants in loci related to synaptic function and neuronal development

(2021) Dmitry Prokopenko et al.   Alzheimers & Dementia

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

(2021) Abhishek Bhattacherjee et al.   Molecular Neurodegeneration

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

Weighted burden analysis of exome‐sequenced late‐onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK‐3β and WNT signalling pathways

(2020) David Curtis et al.   ANNALS OF HUMAN GENETICS

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

(2020) Annerieke Sierksma et al.   EMBO Molecular Medicine

Contributions of DNA Damage to Alzheimer’s Disease

(2020) Xiaozeng Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

(2020) Shea J Andrews et al.   LANCET NEUROLOGY

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

(2020) Luca Kleineidam et al.   ACTA NEUROPATHOLOGICA

Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years

(2020) H. Stocker et al.   MOLECULAR PSYCHIATRY

Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

(2020) Tuancheng Feng et al.   EMBO REPORTS

The role of innate immunity in Alzheimer's disease

(2020) Hannah E. Ennerfelt et al.   IMMUNOLOGICAL REVIEWS

Whole-Exome Sequencing Analysis of Alzheimer’s Disease in Non-APOE*4 Carriers

(2020) Kang-Hsien Fan et al.   JOURNAL OF ALZHEIMERS DISEASE

Tutorial: a guide to performing polygenic risk score analyses

(2020) Shing Wan Choi et al.   Nature Protocols

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

(2020) Karpagam Srinivasan et al.   Cell Reports

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease

(2020) Ruinan Shen et al.   Translational Neurodegeneration

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ 1‐42

(2020) Daniel L. Kober et al.   Alzheimers & Dementia

Interaction of microglia with infiltrating immune cells in the different phases of stroke

(2020) Daniel Berchtold et al.   BRAIN PATHOLOGY

Genetic architecture of Alzheimer's disease

(2020) Sarah M. Neuner et al.   NEUROBIOLOGY OF DISEASE

Somatic mutations in neurodegeneration: An update

(2020) Christos Proukakis   NEUROBIOLOGY OF DISEASE

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

(2020) Hana Saddiki et al.   PLOS MEDICINE

Association of rare variants in neurodegenerative genes with familial Alzheimer’s disease

(2020) Weiwei Zhang et al.   Annals of Clinical and Translational Neurology

Exome sequencing identifies three novel AD‐associated genes

(2020) Henne Holstege et al.   Alzheimers & Dementia

Microglial autophagy‐mediated clearance of amyloid‐beta plaques is dysfunctional in Alzheimer’s disease mice

(2020) Kylene P. Daily et al.   Alzheimers & Dementia

Synonymous variant rs2405442 in PILRA is associated with Alzheimer's disease and affects RNA expression by destroying a ramp sequence

(2020) Justin Miller et al.   Alzheimers & Dementia

Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response

(2020) Anna A. Pimenova et al.   NEUROBIOLOGY OF DISEASE

Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics

(2020) Anna Podleśny-Drabiniok et al.   TRENDS IN NEUROSCIENCES

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

(2020) Marta Olah et al.   Nature Communications

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases

(2019) Anarmaa Mendsaikhan et al.   Cells

Polygenic risk and hazard scores for Alzheimer's disease prediction

(2019) Ganna Leonenko et al.   Annals of Clinical and Translational Neurology

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk

(2019) Amanda McQuade et al.   JOURNAL OF MOLECULAR BIOLOGY

KAT8 selectively inhibits antiviral immunity by acetylating IRF3

(2019) Wanwan Huai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data

(2019) Dominique Campion et al.   ACTA NEUROPATHOLOGICA

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

(2019) Sohaib Nizami et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development

(2019) Laura E. Kuil et al.   GLIA

Somatic mutation that affects transcription factor binding upstream of CD55 in the temporal cortex of a late-onset Alzheimer disease patient

(2019) Hafdis T Helgadottir et al.   HUMAN MOLECULAR GENETICS

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation

(2019) Justin Miron et al.   Alzheimers & Dementia

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

(2019) Rashmi Das et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer’s Disease

(2019) Simone Agostini et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

(2019) Jun Sung Park et al.   Nature Communications

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

(2019) Michael G. Dorrington et al.   Frontiers in Immunology

Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

(2019) Michael A Lodato et al.   HUMAN MOLECULAR GENETICS

SCIMP is a universal Toll‐like receptor adaptor in macrophages

(2019) Lin Luo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms

(2018) Carlos Cruchaga et al.   Alzheimers & Dementia

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Cathepsins: Proteases that are vital for survival but can also be fatal

(2018) Seema Patel et al.   BIOMEDICINE & PHARMACOTHERAPY

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Worldwide distribution of common IDUA pathogenic variants

(2018) E. Poletto et al.   CLINICAL GENETICS

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

(2018) Ashley S. Harms et al.   EXPERIMENTAL NEUROLOGY

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

(2018) Susana Carmona et al.   LANCET NEUROLOGY

FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology

(2018) M. Yasuda-Yamahara et al.   MATRIX BIOLOGY

Use of an Alzheimer’s disease polygenic risk score to identify mild cognitive impairment in adults in their 50s

(2018) Mark W. Logue et al.   MOLECULAR PSYCHIATRY

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Review: Somatic mutations in neurodegeneration

(2018) M. Leija-Salazar et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

(2018) Katherine E. Tansey et al.   Genome Medicine

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection

(2018) Saravanan Raju et al.   PLoS Pathogens

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease

(2018) Badri N. Vardarajan et al.   Annals of Clinical and Translational Neurology

Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease

(2018) Neha S. Raghavan et al.   Annals of Clinical and Translational Neurology

Frequency and signature of somatic variants in 1461 human brain exomes

(2018) Wei Wei et al.   GENETICS IN MEDICINE

Somatic Signature of Brain-Specific Single Nucleotide Variations in Sporadic Alzheimer's Disease

(2018) Antoni Parcerisas et al.   JOURNAL OF ALZHEIMERS DISEASE

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

(2018) Joshua C. Bis et al.   MOLECULAR PSYCHIATRY

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

(2018) Towfique Raj et al.   NATURE GENETICS

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

(2018) Alexandra K. Davies et al.   Nature Communications

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease

(2018) Gaël Nicolas et al.   Alzheimers & Dementia

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

(2018) Christian B Lessard et al.   EMBO Molecular Medicine

CD33 in Alzheimer’s Disease – Biology, Pathogenesis, and Therapeutics: A Mini-Review

(2018) Lingzhi Zhao   GERONTOLOGY

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

(2018) Erik C. B. Johnson et al.   Molecular Neurodegeneration

ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

(2018) Olivia J Conway et al.   Molecular Neurodegeneration

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

High prevalence of focal and multi-focal somatic genetic variants in the human brain

(2018) Michael J. Keogh et al.   Nature Communications

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

(2018) Nisha Rathore et al.   PLoS Genetics

The mucolipin-1 TRPML1 ion channel transmembrane-163 TMEM163 protein and lysosomal zinc handling

(2017) Kirill Kiselyov   Frontiers in Bioscience-Landmark

ABC Transporters Are Key Players in Alzheimer’s Disease

(2017) Cátia D. Pereira et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool

(2017) Shoib S. Siddiqui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

(2017) Valentina Escott-Price et al.   NEUROBIOLOGY OF AGING

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

(2017) Michael J. McConnell et al.   SCIENCE

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

(2017) Lin Luo et al.   Nature Communications

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

(2017) Perry G. Ridge et al.   Genome Medicine

Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease

(2016) Ben J. Gu et al.   ACTA NEUROPATHOLOGICA

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects

(2016) Teng Jiang et al.   CURRENT NEUROVASCULAR RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

(2016) Celeste Sassi et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

(2016) Luxi Shen et al.   Neuroscience Bulletin

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

(2016) Sarah A. Gagliano et al.   Annals of Clinical and Translational Neurology

Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

(2016) Daniel W. Sirkis et al.   Acta Neuropathologica Communications

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

(2016) Maria I. Fonseca et al.   PLoS One

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients

(2015) Carlo Sala Frigerio et al.   Alzheimers & Dementia

Human Umbilical Cord Blood-Derived Monocytes Improve Cognitive Deficits and Reduce Amyloid-β Pathology in PSAPP Mice

(2015) Donna Darlington et al.   CELL TRANSPLANTATION

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

(2015) Sheng Chih Jin et al.   Molecular Neurodegeneration

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Alzheimer's disease is associated with low density of the long CR1 isoform

(2015) Rachid Mahmoudi et al.   NEUROBIOLOGY OF AGING

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

(2015) Diane M Bushman et al.   eLife

Astrocytes and neuroinflammation in Alzheimer's disease

(2014) Emma C. Phillips et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

(2014) M. Ruas et al.   MOLECULAR AND CELLULAR BIOLOGY

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

A genomic view of mosaicism and human disease

(2013) Leslie G. Biesecker et al.   NATURE REVIEWS GENETICS

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling

(2011) P. Draber et al.   MOLECULAR AND CELLULAR BIOLOGY

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY