Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases
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Title
Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases
Authors
Keywords
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Journal
Cells
Volume 8, Issue 3, Pages 230
Publisher
MDPI AG
Online
2019-03-12
DOI
10.3390/cells8030230
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Note: Only part of the references are listed.- The lysosomal function of progranulin, a guardian against neurodegeneration
- (2018) Daniel H. Paushter et al. ACTA NEUROPATHOLOGICA
- Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
- (2018) Aleksandra Deczkowska et al. CELL
- Progranulin: A key player in autoimmune diseases
- (2018) Jinlong Jian et al. CYTOKINE
- Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
- (2018) Masato Hosokawa et al. EXPERIMENTAL ANIMALS
- Alzheimer’s Disease: Advances in Drug Development
- (2018) Morgane Piton et al. JOURNAL OF ALZHEIMERS DISEASE
- Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis
- (2018) Akio Kimura et al. JOURNAL OF NEURO-ONCOLOGY
- Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
- (2018) Andrew E. Arrant et al. JOURNAL OF NEUROSCIENCE
- Progranulin plasma levels predict the presence of GRN mutations in asymptomatic subjects and do not correlate with brain atrophy: results from the GENFI study
- (2018) Daniela Galimberti et al. NEUROBIOLOGY OF AGING
- Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques
- (2018) Feng-Qin Zhou et al. Alzheimers Research & Therapy
- Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies
- (2018) Isabell Lang et al. Frontiers in Immunology
- Astrocytes, Microglia, and Parkinson's Disease
- (2018) Eun-Hye Joe et al. Experimental Neurobiology
- Progranulin is a novel biomarker for predicting an acute exacerbation of chronic obstructive pulmonary disease
- (2018) Xiaoyan Chen et al. Clinical Respiratory Journal
- Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains
- (2018) Douglas G. Walker et al. EXPERIMENTAL NEUROLOGY
- Serum Progranulin Levels in Patients with Frontotemporal Lobar Degeneration and Alzheimer's Disease: Detection of GRN Mutations in a Spanish Cohort
- (2018) Anna Antonell et al. JOURNAL OF ALZHEIMERS DISEASE
- GRN Variant rs5848 Reduces Plasma and Brain Levels of Granulin in Alzheimer's Disease Patients
- (2018) Anna Kämäläinen et al. JOURNAL OF ALZHEIMERS DISEASE
- Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
- (2018) Julia K. Götzl et al. Molecular Neurodegeneration
- Association between progranulin serum levels and dietary intake
- (2018) Bruna Bellincanta Nicoletto et al. PLoS One
- Progranulin aggravates pulmonary immunopathology during influenza virus infection
- (2018) Qin Luo et al. THORAX
- Recent advances in multi-target anti-Alzheimer disease compounds (2013 up to present)
- (2018) Ning Wang et al. CURRENT MEDICINAL CHEMISTRY
- CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
- (2018) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- Immune system responses in Parkinson's disease: Early and dynamic
- (2018) Malú G. Tansey et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis
- (2018) Md. Sahab Uddin et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
- (2018) Sander Beel et al. Molecular Neurodegeneration
- AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity
- (2018) Defne A. Amado et al. MOLECULAR THERAPY
- Translating the biology of aging into novel therapeutics for Alzheimer disease
- (2018) Yuko Hara et al. NEUROLOGY
- Prognostic Value of Progranulin in Patients with Colorectal Cancer Treated with Curative Resection
- (2018) Dong-Hoe Koo et al. PATHOLOGY & ONCOLOGY RESEARCH
- Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice
- (2018) Andrew E. Arrant et al. NEUROBIOLOGY OF DISEASE
- Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
- (2017) Yoshinori Tanaka et al. HUMAN MOLECULAR GENETICS
- The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C
- (2017) Xiaolai Zhou et al. JOURNAL OF NEUROCHEMISTRY
- Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation
- (2017) Terri L. Petkau et al. Journal of Neuroinflammation
- Serum progranulin levels in relation to insulin resistance in childhood obesity
- (2017) Eman M. Alissa et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Nocturnal levels of chemerin and progranulin in adolescents: influence of sex, body mass index, glucose metabolism and sleep
- (2017) Johann Daxer et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- The lysosomal protein cathepsin L is a progranulin protease
- (2017) Chris W. Lee et al. Molecular Neurodegeneration
- Progranulin, lysosomal regulation and neurodegenerative disease
- (2017) Aimee W. Kao et al. NATURE REVIEWS NEUROSCIENCE
- Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice
- (2017) Zoe A. Klein et al. NEURON
- Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
- (2017) Grietje Krabbe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis
- (2017) Michael E. Ward et al. Science Translational Medicine
- Efficacy and safety of anti-amyloid-β immunotherapy for Alzheimer's disease: a systematic review and network meta-analysis
- (2017) Jia-Jie Mo et al. Annals of Clinical and Translational Neurology
- Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency
- (2017) Xiaolai Zhou et al. Acta Neuropathologica Communications
- Rs5848 Variant Influences GRN mRNA Levels in Brain and Peripheral Mononuclear Cells in Patients with Alzheimer's Disease
- (2017) Chiara Fenoglio et al. JOURNAL OF ALZHEIMERS DISEASE
- Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease
- (2017) Jackalina M. Van Kampen et al. PLoS One
- The endocytic pathway in microglia during health, aging and Alzheimer’s disease
- (2016) Santiago Solé-Domènech et al. AGEING RESEARCH REVIEWS
- The role of progranulin in arthritis
- (2016) Jianlu Wei et al. Annals of the New York Academy of Sciences
- Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
- (2016) Elizabeth E. Spangenberg et al. BRAIN
- Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
- (2016) Hansen Lui et al. CELL
- Serum progranulin levels in Hispanic rheumatoid arthritis patients treated with TNF antagonists: a prospective, observational study
- (2016) Jennifer Johnson et al. CLINICAL RHEUMATOLOGY
- Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
- (2016) Carlo Wilke et al. Current Alzheimer Research
- CatacLysMic specificity when targeting myeloid cells?
- (2016) Thomas Blank et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- EphA2 is a functional receptor for the growth factor progranulin
- (2016) Thomas Neill et al. JOURNAL OF CELL BIOLOGY
- Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
- (2016) Christopher J. Holler et al. Molecular Neurodegeneration
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
- (2016) Sebastian R. Nielsen et al. NATURE CELL BIOLOGY
- Loss of exosomes in progranulin-associated frontotemporal dementia
- (2016) Luisa Benussi et al. NEUROBIOLOGY OF AGING
- Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia
- (2016) Carlo Wilke et al. Neurodegenerative Diseases
- Prosaposin is a regulator of progranulin levels and oligomerization
- (2016) Alexandra M. Nicholson et al. Nature Communications
- Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin
- (2016) Simone Buraschi et al. Oncotarget
- Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling
- (2016) Feng Liu et al. Scientific Reports
- Association Between Progranulin and Gaucher Disease
- (2016) Jinlong Jian et al. EBioMedicine
- Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner
- (2016) Jyoti Joshi Mundra et al. Scientific Reports
- Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect
- (2015) Marina Miguel-Álvarez et al. DRUGS & AGING
- Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
- (2015) Xiaolai Zhou et al. JOURNAL OF CELL BIOLOGY
- Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis
- (2015) Yongdui Chen et al. JOURNAL OF NEUROLOGY
- Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice
- (2015) Masato Hosokawa et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels
- (2015) D. A. Salazar et al. JOURNAL OF NEUROSCIENCE
- Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques
- (2015) Swetha Gowrishankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New discovery rarely runs smooth: an update on progranulin/TNFR interactions
- (2015) Betty C. Wang et al. Protein & Cell
- The Evolution of the Secreted Regulatory Protein Progranulin
- (2015) Roger G. E. Palfree et al. PLoS One
- Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis
- (2014) Julia K. Götzl et al. ACTA NEUROPATHOLOGICA
- Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity
- (2014) Qingyun Tian Frontiers in Bioscience-Landmark
- Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease
- (2014) Jinghao Sheng et al. GENE
- Genetic targeting of microglia
- (2014) Peter Wieghofer et al. GLIA
- Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis
- (2014) Yasuko Yamamoto et al. INFLAMMATION
- Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells
- (2014) LI LUO et al. Molecular Medicine Reports
- Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
- (2014) S Sakura Minami et al. NATURE MEDICINE
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
- (2014) Jackalina M. Van Kampen et al. PLoS One
- PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
- (2014) Fanhua Wei et al. Scientific Reports
- TMEM106B expression is reduced in Alzheimer’s disease brains
- (2014) Jun-ichi Satoh et al. Alzheimers Research & Therapy
- Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation
- (2014) Henrieta Scholtzova et al. Acta Neuropathologica Communications
- Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD
- (2013) Michael J. Ungurs et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus
- (2013) Shanshan Zhu et al. BRAIN RESEARCH
- Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice
- (2013) Ryota Kawase et al. CARDIOVASCULAR RESEARCH
- Reduced serum progranulin level might be associated with Parkinson's disease risk
- (2013) I. Mateo et al. EUROPEAN JOURNAL OF NEUROLOGY
- Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)
- (2013) Andrew D. Nguyen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activity-dependent secretion of progranulin from synapses
- (2013) E. Petoukhov et al. JOURNAL OF CELL SCIENCE
- Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
- (2013) Jian Luo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Potential Roles of Microglial Cell Progranulin in HIV-Associated CNS Pathologies and Neurocognitive Impairment
- (2013) Hyeon-Sook Suh et al. Journal of Neuroimmune Pharmacology
- The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
- (2013) Yusuke Egashira et al. Journal of Neuroinflammation
- Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells
- (2013) X. Chen et al. JOURNAL OF NEUROSCIENCE
- Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice
- (2013) Y. Tanaka et al. NEUROSCIENCE
- Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model
- (2013) Huishi Toh et al. PLoS One
- Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage
- (2012) Katherine R. Smith et al. AMERICAN JOURNAL OF HUMAN GENETICS
- PKC Signaling is Involved in the Regulation of Progranulin (Acrogranin/PC-Cell-Derived Growth Factor/Granulin-Epithelin Precursor) Protein Expression in Human Ovarian Cancer Cell Lines
- (2012) Laura Diaz-Cueto et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration
- (2012) Basar Cenik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
- (2012) Lauren Herl Martens et al. JOURNAL OF CLINICAL INVESTIGATION
- Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)
- (2012) Hyeon-Sook Suh et al. PLoS One
- Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity
- (2011) Fiona Pickford et al. AMERICAN JOURNAL OF PATHOLOGY
- Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations
- (2011) Jannet Kocerha et al. BMC GENOMICS
- New vistas on TLR9 activation
- (2011) Hermann Wagner EUROPEAN JOURNAL OF IMMUNOLOGY
- Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling
- (2011) Boyoun Park et al. IMMUNITY
- Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis
- (2011) Marco Vercellino et al. Multiple Sclerosis Journal
- Synaptic dysfunction in progranulin-deficient mice
- (2011) Terri L. Petkau et al. NEUROBIOLOGY OF DISEASE
- C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking
- (2011) Yanqiu Zheng et al. PLoS One
- Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins
- (2011) Sandra Almeida et al. PLoS One
- The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
- (2011) W. Tang et al. SCIENCE
- Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging
- (2010) Zeshan Ahmed et al. AMERICAN JOURNAL OF PATHOLOGY
- Dysregulation of the Mitogen Granulin in Human Cancer through the miR-15/107 microRNA Gene Group
- (2010) W.-X. Wang et al. CANCER RESEARCH
- Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia
- (2010) Fangfang Yin et al. FASEB JOURNAL
- Progranulin expression in the developing and adult murine brain
- (2010) Terri L. Petkau et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration
- (2010) Thomas Philips et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Age-Dependent Changes in Progranulin Expression in the Mouse Brain
- (2010) Takashi MATSUWAKI et al. JOURNAL OF REPRODUCTION AND DEVELOPMENT
- Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines
- (2010) Paola Piscopo et al. NEUROCHEMISTRY INTERNATIONAL
- Update on Frontotemporal Dementia
- (2010) Zoe Arvanitakis NEUROLOGIST
- TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers
- (2010) N. Finch et al. NEUROLOGY
- Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
- (2010) Fenghua Hu et al. NEURON
- MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia
- (2010) Jian Jiao et al. PLoS One
- Progranulin expression is upregulated after spinal contusion in mice
- (2009) Swati B. Naphade et al. ACTA NEUROPATHOLOGICA
- Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
- (2009) Alice S. Chen-Plotkin et al. ACTA NEUROPATHOLOGICA
- Progranulin and β-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation Carrier
- (2009) Gediminas Gliebus et al. American Journal of Alzheimers Disease and Other Dementias
- Progranulin expression in advanced human atherosclerotic plaque
- (2009) Yoji Kojima et al. ATHEROSCLEROSIS
- Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models
- (2009) Sandra Pereson et al. JOURNAL OF PATHOLOGY
- Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease
- (2009) Miryam Carecchio et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Gene expression study on peripheral blood identifies progranulin mutations
- (2008) Giovanni Coppola et al. ANNALS OF NEUROLOGY
- Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury
- (2008) Katie Moisse et al. BRAIN RESEARCH
- Prominent phenotypic variability associated with mutations in Progranulin
- (2007) Brendan J. Kelley et al. NEUROBIOLOGY OF AGING
- Expression patterns in alternative splicing forms of prosaposin mRNA in the rat facial nerve nucleus after facial nerve transection
- (2007) Jie Chen et al. NEUROSCIENCE RESEARCH
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