Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Macrophage Death as a Pharmacological Target in Atherosclerosis

(2019) Wim Martinet et al.   Frontiers in Pharmacology

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

(2019) Celeste M. Karch et al.   Stem Cell Reports

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

A Tale of Two Genes: Microglial Apoe and Trem2

(2017) Anna A. Pimenova et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Transcriptional control of microglia phenotypes in health and disease

(2017) Inge R. Holtman et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

Microglial Priming as Trained Immunity in the Brain

(2017) Michael J. Haley et al.   NEUROSCIENCE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

(2017) Divya Raj et al.   Frontiers in Molecular Neuroscience

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model

(2016) Sung Hoon Baik et al.   GLIA

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

The transcription factor PU.1 is critical for viability and function of human brain microglia

(2013) Amy M. Smith et al.   GLIA

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

(2010) Noelia A-González et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Leukoencephalopathy With Vanishing White Matter: A Review

(2010) Marianna Bugiani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY