The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E

(2016) Shoib Siddiqui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness

(2016) Stevan A. Springer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

(2016) Manuel A. Rivas et al.   Nature Communications

Commentary: is Alzheimer's disease uniquely human?

(2015) Caleb E. Finch et al.   NEUROBIOLOGY OF AGING

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

(2015) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Oxidative Stress during the Progression ofβ-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

(2015) Sara Porcellotti et al.   Oxidative Medicine and Cellular Longevity

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

(2015) Dorothée Diogo et al.   PLoS One

Human-specific derived alleles ofCD33and other genes protect against postreproductive cognitive decline

(2015) Flavio Schwarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of prolonged life after reproduction

(2015) Darren P. Croft et al.   TRENDS IN ECOLOGY & EVOLUTION

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

(2014) Anders Berg Jørgensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

(2014) Elaine T. Lim et al.   PLoS Genetics

Brain peroxisomes

(2013) D. Trompier et al.   BIOCHIMIE

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

(2013) Francesca Fanelli et al.   Molecular Neurodegeneration

Diversity of ageing across the tree of life

(2013) Owen R. Jones et al.   NATURE

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics

(2010) Natasha L. Grimsey et al.   BIOCHEMICAL PHARMACOLOGY

BLAST-EXPLORER helps you building datasets for phylogenetic analysis

(2010) Alexis Dereeper et al.   BMC EVOLUTIONARY BIOLOGY

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activation of Gαi3 triggers cell migration via regulation of GIV

(2008) Pradipta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Tauopathy with paired helical filaments in an aged chimpanzee

(2008) Rebecca F. Rosen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH