Journal
CURRENT NEUROVASCULAR RESEARCH
Volume 13, Issue 4, Pages 318-320Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567202613666160808095530
Keywords
TREM2; Alzheimer's disease; meta-analysis; p, H157Y; rs2234255; Variant
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Funding
- National Natural Science Foundation of China [81501092, 81471309]
- Natural Science Foundation of Jiangsu Province [BK20150091]
- China Postdoctoral Science Foundation [2015M580448, 2016T90480]
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We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p. H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p. H157Y was associated with an increased risk of AD (OR= 3.65, 95% CI: 1.61-8.28; P=0.002), further establishing TREM2 as an important susceptibility gene for this disease.
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