Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
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Title
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
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Journal
CARDIOVASCULAR RESEARCH
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2022-01-05
DOI
10.1093/cvr/cvab370
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Note: Only part of the references are listed.- Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
- (2021) Maike Schuldt et al. Circulation-Heart Failure
- Cellular and molecular pathobiology of heart failure with preserved ejection fraction
- (2021) Sumita Mishra et al. Nature Reviews Cardiology
- Human heart-forming organoids recapitulate early heart and foregut development
- (2021) Lika Drakhlis et al. NATURE BIOTECHNOLOGY
- Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms
- (2021) Natalija Bogunovic et al. JOURNAL OF ENDOVASCULAR THERAPY
- A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature
- (2021) Benjamin Fook Lun Lai et al. Nature Protocols
- Experimental animal models of coronary microvascular dysfunction
- (2020) Oana Sorop et al. CARDIOVASCULAR RESEARCH
- Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction
- (2020) Katharina Schimmel et al. CIRCULATION
- The ‘Digital Twin’ to enable the vision of precision cardiology
- (2020) Jorge Corral-Acero et al. EUROPEAN HEART JOURNAL
- How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
- (2020) Burkert Pieske et al. EUROPEAN JOURNAL OF HEART FAILURE
- Peripartum Cardiomyopathy
- (2020) Melinda B. Davis et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
- (2020) A. Moretti et al. NATURE MEDICINE
- Canine Dilated Cardiomyopathy: Diffuse Remodeling, Focal Lesions, and the Involvement of Macrophages and New Vessel Formation
- (2020) Stefania Gasparini et al. VETERINARY PATHOLOGY
- Preclinical development of a miR-132 inhibitor for heart failure treatment
- (2020) Ariana Foinquinos et al. Nature Communications
- Deriving disease modules from the compressed transcriptional space embedded in a deep autoencoder
- (2020) Sanjiv K. Dwivedi et al. Nature Communications
- A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures
- (2020) András Makkos et al. Frontiers in Physiology
- Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency
- (2020) Umber Saleem et al. Stem Cell Reports
- Deep learning approach based on dimensionality reduction for designing electromagnetic nanostructures
- (2020) Yashar Kiarashinejad et al. npj Computational Materials
- The Network Medicine Imperative and the Need for an International Network Medicine Consortium
- (2020) Paolo Parini et al. AMERICAN JOURNAL OF MEDICINE
- Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction
- (2020) Natalie A. Noll et al. AMERICAN JOURNAL OF PATHOLOGY
- Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function
- (2020) Serena Zacchigna et al. CARDIOVASCULAR RESEARCH
- Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
- (2020) Elisa Giacomelli et al. Cell Stem Cell
- The role of genetics in cardiovascular disease: arrhythmogenic cardiomyopathy
- (2020) Cynthia A James et al. EUROPEAN HEART JOURNAL
- Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics
- (2020) Fotios G. Pitoulis et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction
- (2020) Paul W. Armstrong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy
- (2020) Louise L. A. M. Nijenkamp et al. PLoS One
- Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
- (2020) Henry Sutanto et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Efficient targeted integration directed by short homology in zebrafish and mammalian cells
- (2020) Wesley A Wierson et al. eLife
- Computational Hemodynamic Modeling of Arterial Aneurysms: A Mini-Review
- (2020) Sarah N. Lipp et al. Frontiers in Physiology
- Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation
- (2020) Marit Wiersma et al. Cells
- Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
- (2020) Dylan J. Richards et al. Nature Biomedical Engineering
- Mutation-specific pathology and treatment of hypertrophic cardiomyopathy in patients, mouse models and human engineered heart tissue
- (2020) Paul J.M. Wijnker et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
- (2020) Carlo G Tocchetti et al. CARDIOVASCULAR RESEARCH
- Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
- (2020) Jan W. Buikema et al. Cell Stem Cell
- Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation
- (2020) Antoinette F. van Ouwerkerk et al. CIRCULATION RESEARCH
- SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control
- (2020) Martin R. Cowie et al. Nature Reviews Cardiology
- Toward acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices
- (2020) Katja Findeisen et al. XENOTRANSPLANTATION
- Large animals as models of atrial fibrillation
- (2020) Piotr Frydrychowski et al. Advances in Clinical and Experimental Medicine
- A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection
- (2020) Mario Rienzo et al. Scientific Reports
- Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement
- (2020) Ilkka Heinonen et al. Scientific Reports
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- (2020) Edgar E. Nollet et al. Frontiers in Physiology
- A practical guide for investigating cardiac physiology using living myocardial slices
- (2020) S. A. Watson et al. BASIC RESEARCH IN CARDIOLOGY
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- (2020) Jiayin Fu et al. BIOMATERIALS
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- (2020) Job A.J. Verdonschot et al. CIRCULATION
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- (2020) Marie AC Depuydt et al. CIRCULATION RESEARCH
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- (2020) Sandor Batkai et al. EUROPEAN HEART JOURNAL
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- (2020) Jasmeet S. Reyat et al. JCI Insight
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- (2020) Martijn F. Hoes et al. CIRCULATION
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- (2020) Mariana S. Parahuleva et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2019) Elizabeth Min et al. EXPERIMENTAL CELL RESEARCH
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- (2019) Carola Fischer et al. Nature Communications
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- (2019) Rajat Vashistha et al. Journal of Biological Engineering
- In Situ Generated Medical Devices
- (2019) Daniel Cohn et al. Advanced Healthcare Materials
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- (2019) Deli Zhang et al. Nature Communications
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- (2019) Taha Rehmani et al. MOLECULES
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- (2019) Carlos Galán-Arriola et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2019) Kathryn M. Meurs et al. HUMAN GENETICS
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- (2019) Mark McClellan et al. CIRCULATION
- Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
- (2019) Richard J. Mills et al. Cell Stem Cell
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- (2019) Lorna R. Fiedler et al. Cell Stem Cell
- Dr.VAE: Improving drug response prediction via modeling of drug perturbation effects
- (2019) Ladislav Rampášek et al. BIOINFORMATICS
- Early Insight into In-vivo recellularization of cell-free allogenic heart valves
- (2019) Samir Sarikouch et al. ANNALS OF THORACIC SURGERY
- Tunable and Reversible Substrate Stiffness Reveals Dynamic Mechanosensitivity of Cardiomyocytes
- (2019) Elise Corbin et al. ACS Applied Materials & Interfaces
- Nitrosative stress drives heart failure with preserved ejection fraction
- (2019) Gabriele G. Schiattarella et al. NATURE
- Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long term chronic canine atrial fibrillation model
- (2019) Kennosuke Yamashita et al. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
- Renal Sympathetic Denervation Improves Outcomes in a Canine Myocardial Infarction Model
- (2019) Buajieer-guli Nasi-Er et al. MEDICAL SCIENCE MONITOR
- A multilayer micromechanical elastic modulus measuring method in ex vivo human aneurysmal abdominal aortas
- (2019) Jorn P. Meekel et al. Acta Biomaterialia
- The Cardiovascular Research community calls for action to address the growing burden of cardiovascular disease
- (2019) Jeremy Pearson et al. CARDIOVASCULAR RESEARCH
- Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose-dependent manner: implications for inotropy
- (2019) Panagiotis Efentakis et al. CARDIOVASCULAR RESEARCH
- Small animal models of heart failure
- (2019) Christian Riehle et al. CARDIOVASCULAR RESEARCH
- Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue
- (2019) Sung-Jin Park et al. CIRCULATION
- A feline orthologue of the human MYH7 c.5647G>A (p.(Glu1883Lys)) variant causes hypertrophic cardiomyopathy in a Domestic Shorthair cat
- (2019) Tom Schipper et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo
- (2019) Nikita Ved et al. LABORATORY ANIMALS
- GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
- (2019) Peter R. T. Bowman et al. PLoS One
- Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
- (2019) Samuel A. Watson et al. Nature Communications
- Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications
- (2019) Sandra Pina et al. Materials
- Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology
- (2019) Natalija Bogunovic et al. Scientific Reports
- Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile
- (2019) Ayla Hoogendoorn et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Design and protocol of a comprehensive multicentre biobank for abdominal aortic aneurysms
- (2019) Hamid Jalalzadeh et al. BMJ Open
- Atherosclerosis
- (2019) Peter Libby et al. Nature Reviews Disease Primers
- Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes
- (2019) Yuichi Horikoshi et al. Cells
- Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems
- (2019) Simon P. Wells et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Development of a new mouse model for coxsackievirus-induced myocarditis by attenuating coxsackievirus B3 virulence in the pancreas
- (2019) Sandra Pinkert et al. CARDIOVASCULAR RESEARCH
- Peripartum cardiomyopathy: basic mechanisms and hope for new therapies
- (2019) Melanie Ricke-Hoch et al. CARDIOVASCULAR RESEARCH
- HFpEF—Time to Explore the Role of Genetic Heterogeneity in Phenotypic Variability
- (2019) Enzo R. Porrello et al. CIRCULATION
- An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
- (2019) Wenxuan Cai et al. CIRCULATION RESEARCH
- Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
- (2019) Maksymilian Prondzynski et al. EMBO Molecular Medicine
- Living myocardial slices: a novel multicellular model for cardiac translational research
- (2019) Filippo Perbellini et al. EUROPEAN HEART JOURNAL
- P1229Massive expansion of native human atrial cardiomyocytes through immortogenetics: generation of the hiAM cell lines
- (2019) N Harlaar et al. EUROPEAN HEART JOURNAL
- Single-cell immune landscape of human atherosclerotic plaques
- (2019) Dawn M. Fernandez et al. NATURE MEDICINE
- Genetics of dilated cardiomyopathy: practical implications for heart failure management
- (2019) Andrew N. Rosenbaum et al. Nature Reviews Cardiology
- Simultaneous measurement of contraction, voltage and calcium in HIPSC-CMS for the detection of inotropic effects under blinded conditions
- (2019) Tessa de Korte et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Refining animal research: The Animal Study Registry
- (2019) Bettina Bert et al. PLOS BIOLOGY
- Selective chemical ablation of transient receptor potential vanilloid 1 expressing neurons in the left stellate ganglion protects against ischemia-induced ventricular arrhythmias in dogs
- (2019) Mingmin Zhou et al. BIOMEDICINE & PHARMACOTHERAPY
- Myocardial slices come to age: an intermediate complexity in vitro cardiac model for translational research
- (2019) Fotios G Pitoulis et al. CARDIOVASCULAR RESEARCH
- Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
- (2018) Amy Cochrane et al. ADVANCED DRUG DELIVERY REVIEWS
- Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity
- (2018) Jia Liu et al. CARDIOVASCULAR RESEARCH
- Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
- (2018) Oana Sorop et al. CARDIOVASCULAR RESEARCH
- Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
- (2018) Antoine Bondue et al. CARDIOVASCULAR RESEARCH
- H19 Induces Abdominal Aortic Aneurysm Development and Progression
- (2018) Daniel Y. Li et al. CIRCULATION
- Teasing Apart Heart Failure With Preserved Ejection Fraction Phenotypes With Echocardiographic Imaging
- (2018) Edgar Argulian et al. CIRCULATION RESEARCH
- Pathobiology of cardiac dyssynchrony and resynchronization therapy
- (2018) Uyên Châu Nguyên et al. EUROPACE
- The Future Treatment of Heart Failure?
- (2018) Milton Packer EUROPEAN HEART JOURNAL
- Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion
- (2018) Albert Busch et al. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
- Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues
- (2018) Andrea Leonard et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Aortic valve cell seeding into decellularized animal pericardium by perfusion-assisted bioreactor
- (2018) Francesco Amadeo et al. Journal of Tissue Engineering and Regenerative Medicine
- Multi-ethnic genome-wide association study for atrial fibrillation
- (2018) Carolina Roselli et al. NATURE GENETICS
- Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure
- (2018) Christina Yingxian Chen et al. NATURE MEDICINE
- Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
- (2018) Maximilian Y. Emmert et al. Science Translational Medicine
- Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model
- (2018) Ahmad F. Hedayat et al. Translational Research
- Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
- (2018) David Pamies ALTEX-Alternatives to Animal Experimentation
- miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway
- (2018) Marta Diez-Cuñado et al. Cell Reports
- Predicting Aging of Brain Metabolic Topography Using Variational Autoencoder
- (2018) Hongyoon Choi et al. Frontiers in Aging Neuroscience
- Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive—A New Preclinical Model
- (2018) Claire L. Curl et al. Journal of the American Heart Association
- Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture
- (2018) Menno E. Groeneveld et al. Journal of the American Heart Association
- Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture
- (2018) Ruth Olmer et al. Stem Cell Reports
- Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation
- (2018) Miguel Castilho et al. ADVANCED FUNCTIONAL MATERIALS
- Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
- (2018) Hans Erik Bøtker et al. BASIC RESEARCH IN CARDIOLOGY
- Activation of human aortic valve interstitial cells by local stiffness involves YAP-dependent transcriptional signaling
- (2018) Rosaria Santoro et al. BIOMATERIALS
- Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans
- (2018) Yoshito Yamashiro et al. CIRCULATION RESEARCH
- 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
- (2018) Vera Regitz-Zagrosek et al. EUROPEAN HEART JOURNAL
- Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
- (2018) Maria Kotini et al. Nature Communications
- MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium
- (2018) Bence Ágg et al. Scientific Reports
- Molecular Cytogenetics and Quality Control: Clinical Guardians for Pluripotent Stem Cells
- (2018) Leili Rohani et al. Stem Cells Translational Medicine
- Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload
- (2018) Zhen Ma et al. Nature Biomedical Engineering
- Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA
- (2018) Dongjian Hu et al. CIRCULATION RESEARCH
- The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM
- (2018) Nicoletta Piroddi et al. JOURNAL OF GENERAL PHYSIOLOGY
- Consistent success in life-supporting porcine cardiac xenotransplantation
- (2018) Matthias Längin et al. NATURE
- Computational models in cardiology
- (2018) Steven A. Niederer et al. Nature Reviews Cardiology
- Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium
- (2018) Marta Lemme et al. Stem Cell Reports
- Abdominal aortic aneurysms
- (2018) Natzi Sakalihasan et al. Nature Reviews Disease Primers
- Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
- (2017) Gregory A. Roth et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension
- (2017) Mariann Gyöngyösi et al. Journal of Translational Medicine
- In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature
- (2017) Tamás Baranyai et al. Journal of Translational Medicine
- A novel chronic advanced stage abdominal aortic aneurysm murine model
- (2017) Guanyi Lu et al. JOURNAL OF VASCULAR SURGERY
- Heart failure
- (2017) Marco Metra et al. LANCET
- Preparation of viable adult ventricular myocardial slices from large and small mammals
- (2017) Samuel A Watson et al. Nature Protocols
- Feeling the right force: How to contextualize the cell mechanical behavior in physiologic turnover and pathologic evolution of the cardiovascular system
- (2017) Maurizio Pesce et al. PHARMACOLOGY & THERAPEUTICS
- Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease
- (2017) Ana M. Porras et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
- (2017) Arun Sharma et al. Science Translational Medicine
- Status of Therapeutic Gene Transfer to Treat Cardiovascular Disease in Dogs and Cats
- (2017) Meg M. Sleeper VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
- A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function
- (2017) Markus Wallner et al. Scientific Reports
- Large animal model of functional tricuspid regurgitation in pacing induced end-stage heart failure
- (2017) Marcin Malinowski et al. Interactive Cardiovascular and Thoracic Surgery
- Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
- (2017) Elisa Passini et al. Frontiers in Physiology
- Heart failure with reduced ejection fraction
- (2017) Michelle W. Bloom et al. Nature Reviews Disease Primers
- Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling
- (2017) Noemi Pavo et al. Scientific Reports
- Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density
- (2017) Marc D. Lemoine et al. Scientific Reports
- hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen
- (2017) André Monteiro da Rocha et al. Scientific Reports
- The canine era: the rise of a biomedical model
- (2016) F. G. van Steenbeek et al. ANIMAL GENETICS
- The Virtual Physiological Human: Ten Years After
- (2016) Marco Viceconti et al. Annual Review of Biomedical Engineering
- High throughput physiological screening of iPSC-derived cardiomyocytes for drug development
- (2016) Juan C. del Álamo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
- (2016) Chris Denning et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Large animal models of cardiovascular disease
- (2016) H. G. Tsang et al. CELL BIOCHEMISTRY AND FUNCTION
- Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction
- (2016) Sanjiv J. Shah et al. CIRCULATION
- Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases
- (2016) Yigal M. Pinto et al. EUROPEAN HEART JOURNAL
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
- (2016) Piotr Ponikowski et al. EUROPEAN HEART JOURNAL
- European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions
- (2016) Maria G. Crespo-Leiro et al. EUROPEAN JOURNAL OF HEART FAILURE
- Animal Models Used to Explore Abdominal Aortic Aneurysms: A Systematic Review
- (2016) J. Lysgaard Poulsen et al. EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
- Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging
- (2016) Brian G. Reid et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Telemetry for small animal physiology
- (2016) James E. Niemeyer LAB ANIMAL
- Bioprinted thrombosis-on-a-chip
- (2016) Yu Shrike Zhang et al. LAB ON A CHIP
- Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
- (2016) Jérôme Nicod et al. NATURE GENETICS
- Cardioprotection and lifespan extension by the natural polyamine spermidine
- (2016) Tobias Eisenberg et al. NATURE MEDICINE
- Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
- (2016) James S. Ware et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Prospective Study of Sudden Cardiac Death among Children and Young Adults
- (2016) Richard D. Bagnall et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes
- (2016) Alison J. Kriegel et al. Journal of Cardiovascular Translational Research
- Animal models of heart failure with preserved ejection fraction
- (2016) G. Conceição et al. Netherlands Heart Journal
- OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology
- (2016) Aleksandra Klimas et al. Nature Communications
- Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models
- (2016) Hermenegild J. Arevalo et al. Nature Communications
- Patient involvement in clinical research: why, when, and how
- (2016) Jose A Sacristan et al. Patient Preference and Adherence
- Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction
- (2016) Constantijn Franssen et al. JACC-Heart Failure
- The FAIR Guiding Principles for scientific data management and stewardship
- (2016) Mark D. Wilkinson et al. Scientific Data
- Cardiac tissue slices: preparation, handling, and successful optical mapping
- (2015) Ken Wang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction
- (2015) Michael Schwarzl et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A Mouse Model of Heart Failure with Preserved Ejection Fraction due to Chronic Infusion of a Low Subpressor Dose of Angiotensin II
- (2015) Jessica A Regan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models
- (2015) Gerardus P. J. van Hout et al. CARDIOVASCULAR RESEARCH
- Animal and in silico models for the study of sarcomeric cardiomyopathies
- (2015) D. J. Duncker et al. CARDIOVASCULAR RESEARCH
- Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
- (2015) Tromondae K Feaster et al. CIRCULATION RESEARCH
- Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology
- (2015) H. D. Devalla et al. EMBO Molecular Medicine
- Heart failure: when form fails to follow function
- (2015) Arnold M. Katz et al. EUROPEAN HEART JOURNAL
- Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions
- (2015) Daniel Y Cheung et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Large animal models of atherosclerosis - new tools for persistent problems in cardiovascular medicine
- (2015) J Shim et al. JOURNAL OF PATHOLOGY
- Arrhythmogenic right ventricular cardiomyopathy coincided with the cardiac fibrosis in the inner muscle layer of the left ventricular wall in a boxer dog
- (2015) Naoaki YAMADA et al. JOURNAL OF VETERINARY MEDICAL SCIENCE
- A review of: Application of synthetic scaffold in tissue engineering heart valves
- (2015) Ehsan Fallahiarezoudar et al. Materials Science & Engineering C-Materials for Biological Applications
- Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment
- (2015) Larissa Fabritz et al. Nature Reviews Cardiology
- Zebrafish as tools for drug discovery
- (2015) Calum A. MacRae et al. NATURE REVIEWS DRUG DISCOVERY
- Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types
- (2015) Kimberly R. Doherty et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Genetics of Human and Canine Dilated Cardiomyopathy
- (2015) Siobhan Simpson et al. International Journal of Genomics
- Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)
- (2015) Jessie Rose Payne et al. Journal of Veterinary Cardiology
- Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters
- (2015) Rami Shinnawi et al. Stem Cell Reports
- Atherosclerotic Plaque Destabilization in Mice: A Comparative Study
- (2015) Helene Hartwig et al. PLoS One
- The influence of physiological matrix conditions on permanent culture of induced pluripotent stem cell-derived cardiomyocytes
- (2014) Carlos O. Heras-Bautista et al. BIOMATERIALS
- Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes
- (2014) Max R. Salick et al. BIOMATERIALS
- Evaluation of a porcine model of early aortic valve sclerosis
- (2014) Krista L. Sider et al. CARDIOVASCULAR PATHOLOGY
- Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform
- (2014) Arun Sharma et al. CIRCULATION RESEARCH
- Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation
- (2014) Jun Mori et al. Circulation-Heart Failure
- New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes
- (2014) M. Senni et al. EUROPEAN HEART JOURNAL
- Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
- (2014) Carole Van der Donckt et al. EUROPEAN HEART JOURNAL
- Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy
- (2014) K. Y. van Spaendonck-Zwarts et al. EUROPEAN HEART JOURNAL
- 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
- (2014) EUROPEAN HEART JOURNAL
- Atlas of the clinical genetics of human dilated cardiomyopathy
- (2014) Jan Haas et al. EUROPEAN HEART JOURNAL
- All preclinical trials should be registered in advance in an online registry
- (2014) Sanne J. Jansen of Lorkeers et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Meta-Analyses of Animal Studies: An Introduction of a Valuable Instrument to Further Improve Healthcare
- (2014) C. R. Hooijmans et al. ILAR JOURNAL
- Murine Models of Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction
- (2014) S. Horgan et al. JOURNAL OF CARDIAC FAILURE
- Inhibition of miR-25 improves cardiac contractility in the failing heart
- (2014) Christine Wahlquist et al. NATURE
- Pathophysiology and epidemiology of peripartum cardiomyopathy
- (2014) Denise Hilfiker-Kleiner et al. Nature Reviews Cardiology
- Cardiac valve cells and their microenvironment—insights from in vitro studies
- (2014) Huan Wang et al. Nature Reviews Cardiology
- Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice
- (2014) Marc van Bilsen et al. PLoS One
- Mechanoregulation of valvular interstitial cell phenotype in the third dimension
- (2013) Mehmet H. Kural et al. BIOMATERIALS
- Biomechanical factors in the biology of aortic wall and aortic valve diseases
- (2013) Magnus Bäck et al. CARDIOVASCULAR RESEARCH
- Molecular Changes After Left Ventricular Assist Device Support for Heart Failure
- (2013) Emma J. Birks CIRCULATION RESEARCH
- Epidemiology of Heart Failure
- (2013) Véronique L. Roger CIRCULATION RESEARCH
- Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model
- (2013) Nazha Hamdani et al. Circulation-Heart Failure
- Forecasting the Impact of Heart Failure in the United States
- (2013) Paul A. Heidenreich et al. Circulation-Heart Failure
- Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans
- (2013) Peter Libby et al. IMMUNITY
- The annual global economic burden of heart failure
- (2013) Christopher Cook et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Computational Fluid Dynamics Applied to Cardiac Computed Tomography for Noninvasive Quantification of Fractional Flow Reserve
- (2013) Charles A. Taylor et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
- (2013) Walter J. Paulus et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Glucose Metabolism, Hyperosmotic Stress, and Reprogramming of Somatic Cells
- (2013) Rosalinda Madonna et al. MOLECULAR BIOTECHNOLOGY
- A systematic genome-wide analysis of zebrafish protein-coding gene function
- (2013) Ross N. W. Kettleborough et al. NATURE
- Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
- (2013) Marcel den Hoed et al. NATURE GENETICS
- Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway
- (2013) H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Age- and Gender-Related Changes in Ventricular Performance in Wild-Type FVB/N Mice as Evaluated by Conventional and Vector Velocity Echocardiography Imaging: A Retrospective Study
- (2013) Sheryl E. Koch et al. ULTRASOUND IN MEDICINE AND BIOLOGY
- Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia
- (2013) Damir Hamamdzic et al. Journal of Diabetes Research
- Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis
- (2012) Zi-Lun Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The calcium chloride-induced rodent model of abdominal aortic aneurysm
- (2012) Yutang Wang et al. ATHEROSCLEROSIS
- Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy
- (2012) Raffaele Coppini et al. CIRCULATION
- Lost in Transgenesis
- (2012) Jennifer Davis et al. CIRCULATION RESEARCH
- Animal Models of Heart Failure
- (2012) Steven R. Houser et al. CIRCULATION RESEARCH
- Cellular Mechanisms of Aortic Valve Calcification
- (2012) Jane A. Leopold Circulation-Cardiovascular Interventions
- Polymeric trileaflet prosthetic heart valves: evolution and path to clinical reality
- (2012) Thomas E Claiborne et al. Expert Review of Medical Devices
- A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher
- (2012) Kathryn M. Meurs et al. HUMAN GENETICS
- Calcific Aortic Stenosis
- (2012) Marc R. Dweck et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Bicuspid aortic valves undergo excessive strain during opening: A simulation study
- (2012) Susumu Katayama et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Functional screening identifies miRNAs inducing cardiac regeneration
- (2012) Ana Eulalio et al. NATURE
- Heat Shock Protein–Inducing Compounds as Therapeutics to Restore Proteostasis in Atrial Fibrillation
- (2012) Femke Hoogstra-Berends et al. TRENDS IN CARDIOVASCULAR MEDICINE
- The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
- (2012) Ahmet Ucar et al. Nature Communications
- Performance of SynerGraft Decellularized Pulmonary Homograft in Patients Undergoing a Ross Procedure
- (2011) John W. Brown et al. ANNALS OF THORACIC SURGERY
- Zebrafish as a model to study cardiac development and human cardiac disease
- (2011) J. Bakkers CARDIOVASCULAR RESEARCH
- Heart Failure With Preserved Ejection Fraction
- (2011) James E. Udelson CIRCULATION
- Cardiac remodeling and diastolic dysfunction in DahlS.Z-Lepr fa /Lepr fa rats: a new animal model of metabolic syndrome
- (2011) Tamayo Murase et al. HYPERTENSION RESEARCH
- A minimally-invasive closed chest myocardial occlusion-reperfusion model in rhesus monkeys (Macaca mulatta): monitoring by contrast-enhanced ultrasound imaging
- (2011) Hugues Contamin et al. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
- Atherosclerosis and Thrombosis: Insights from Large Animal Models
- (2011) Gemma Vilahur et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis
- (2011) Elza D. van Deel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes
- (2011) Claudia Jentzsch et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Myocarditis
- (2011) Sandeep Sagar et al. LANCET
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
- (2011) Ulrich Schotten et al. PHYSIOLOGICAL REVIEWS
- Animal Models of Dyssynchrony
- (2011) Marc Strik et al. Journal of Cardiovascular Translational Research
- Data reduction for spectral clustering to analyze high throughput flow cytometry data
- (2010) Habil Zare et al. BMC BIOINFORMATICS
- Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
- (2010) Gad A. Silberman et al. CIRCULATION
- Systolic Heart Failure
- (2010) John J.V. McMurray NEW ENGLAND JOURNAL OF MEDICINE
- Large animal models for diastolic dysfunction and diastolic heart failure—a review of the literature
- (2009) Shay Dubi et al. CARDIOVASCULAR PATHOLOGY
- Notch1 represses osteogenic pathways in aortic valve cells
- (2009) Vishal Nigam et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Substrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes
- (2008) Jeffrey G. Jacot et al. BIOPHYSICAL JOURNAL
- Insulin signalling in the heart
- (2008) L. Bertrand et al. CARDIOVASCULAR RESEARCH
- Drug-Eluting Stents in Preclinical Studies
- (2008) Robert S. Schwartz et al. Circulation-Cardiovascular Interventions
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