Biomechanical factors in the biology of aortic wall and aortic valve diseases

Spatial orientation of collagen fibers in the abdominal aortic aneurysm’s wall and its relation to wall mechanics

(2012) T. Christian Gasser et al.   Acta Biomaterialia

The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface

(2012) Choon Hwai Yap et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity

(2012) Edit Nagy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation

(2012) Wei-dong Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease

(2012) Santanu Chandra et al.   Biomechanics and Modeling in Mechanobiology

Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis

(2012) Edit Nagy et al.   FEBS LETTERS

Impact of aortic regurgitation on the prognosis of severe aortic stenosis

(2012) Satoshi Honda et al.   HEART

An Integrated Fluid-Chemical Model Toward Modeling the Formation of Intra-Luminal Thrombus in Abdominal Aortic Aneurysms

(2012) Jacopo Biasetti et al.   Frontiers in Physiology

Differences in valvular and vascular cell responses to strain in osteogenic media

(2011) Zannatul Ferdous et al.   BIOMATERIALS

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts

(2011) Edit Nagy et al.   CIRCULATION

Cardiovascular Calcification

(2011) Sophie E. P. New et al.   CIRCULATION JOURNAL

Early Atheroma-Derived Agonists of Peroxisome Proliferator–Activated Receptor-γ Trigger Intramedial Angiogenesis in a Smooth Muscle Cell–Dependent Manner

(2011) Benoît Ho-Tin-Noé et al.   CIRCULATION RESEARCH

The Role of Matrix Metalloproteinases in Atherothrombosis

(2011) Daniel F. J. Ketelhuth et al.   Current Atherosclerosis Reports

Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intra-luminal thrombus formation

(2011) J. Biasetti et al.   Journal of the Royal Society Interface

Restricted cusp motion in right-left type of bicuspid aortic valves: A new risk marker for aortopathy

(2011) Alessandro Della Corte et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

(2010) J.-B. Michel et al.   CARDIOVASCULAR RESEARCH

Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms: Model Complexity versus Predictability of Finite Element Simulations

(2010) T.C. Gasser et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta

(2010) Luciano F Borges et al.   HISTOPATHOLOGY

The epigenetic mechanism of mechanically induced osteogenic differentiation

(2010) Emily J. Arnsdorf et al.   JOURNAL OF BIOMECHANICS

Micromechanical Characterization of Intra-luminal Thrombus Tissue from Abdominal Aortic Aneurysms

(2009) T. Christian Gasser et al.   ANNALS OF BIOMEDICAL ENGINEERING

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells

(2009) Kathryn E. Smith et al.   Biomechanics and Modeling in Mechanobiology

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus

(2009) Xavier Houard et al.   FASEB JOURNAL

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY

Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps

(2009) Ismail El-Hamamsy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Will the Real Plaque Vasculature Please Stand Up? Why We Need to Distinguish the Vasa Plaquorum From the Vasa Vasorum

(2009) Zorina S. Galis et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm

(2008) Ziad Touat et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenovirus-Mediated VEGF Gene Therapy Enhances Venous Thrombus Recanalization and Resolution

(2008) B. Modarai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Discovery of the Role of Wall Shear in Atherosclerosis

(2008) C.G. Caro   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Histological features of human abdominal aortic aneurysm are not related to clinical characteristics

(2008) Femke A.M.V.I. Hellenthal et al.   CARDIOVASCULAR PATHOLOGY

The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape

(2008) B M Schaefer et al.   HEART

Failure properties of intraluminal thrombus in abdominal aortic aneurysm under static and pulsating mechanical loads

(2008) T. Christian Gasser et al.   JOURNAL OF VASCULAR SURGERY

Low-density lipoprotein (LDL) transport in an artery – A simplified analytical solution

(2007) Ning Yang et al.   INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER