OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

Optogenetic versus Electrical Stimulation of Human Cardiomyocytes: Modeling Insights

(2015) John C. Williams et al.   BIOPHYSICAL JOURNAL

Optical control of excitation waves in cardiac tissue

(2015) Rebecca A. B. Burton et al.   Nature Photonics

Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability

(2015) Christina M. Ambrosi et al.   Scientific Reports

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

(2014) Daniel R Hochbaum et al.   NATURE METHODS

Cardiac applications of optogenetics

(2014) Christina M. Ambrosi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Rapid Cellular Phenotyping of Human Pluripotent Stem Cell-Derived Cardiomyocytes using a Genetically Encoded Fluorescent Voltage Sensor

(2014) Jordan S. Leyton-Mange et al.   Stem Cell Reports

Cardiac optogenetics

(2013) Emilia Entcheva   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2013) Björn C. Knollmann   CIRCULATION RESEARCH

Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model

(2013) John C. Williams et al.   PLoS Computational Biology

The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening

(2012) Jaffar M Khan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After β-Adrenergic Stimulation

(2012) Daniel M. Johnson et al.   CIRCULATION RESEARCH

Induced pluripotent stem cells: the new patient?

(2012) Milena Bellin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Stimulating Cardiac Muscle by Light

(2011) Zhiheng Jia et al.   Circulation-Arrhythmia and Electrophysiology

A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms

(2011) J. D. Moreno et al.   Science Translational Medicine

The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

(2010) B Rodriguez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization

(2010) Chiung-yin Chung et al.   FASEB JOURNAL

Renaissance of ion channel research and drug discovery by patch clamp automation

(2010) Niels Fertig et al.   Future Medicinal Chemistry

Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

(2009) Jonathan P. Piccini et al.   AMERICAN HEART JOURNAL

Effect of Voltage Sensitive Fluorescent Proteins on Neuronal Excitability

(2009) Walther Akemann et al.   BIOPHYSICAL JOURNAL

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

(2008) Mark Bowlby et al.   CURRENT DRUG METABOLISM

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY