Review
Plant Sciences
Xiao-Le Wang, Ya-Ting Wang, Zhen-Yu Guo, Ning-Ning Zhang, Yuan-Yuan Wang, Die Hu, Zhen-Zhen Wang, Yi Zhang
Summary: This study systematically reviewed and meta-analyzed the effectiveness of paeoniflorin in relieving depressive-like behaviors in animal models. The results showed that paeoniflorin significantly improved depressive-like symptoms in animals, suggesting its potential as a therapy for depression in the future.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xing-Bo Bian, Peng-Cheng Yu, Xiao-Hang Yang, Liu Han, Qi-Yao Wang, Li Zhang, Lian-Xue Zhang, Xin Sun
Summary: Ginsenosides have significant efficacy against liver injury, targeting antioxidant, anti-inflammatory, and apoptotic-related pathways. However, current studies have low methodological quality, and more high-quality research is needed to further confirm their effects and mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angelo Luis, Helena Marcelino, Fernanda Domingues, Luisa Pereira, Jose Francisco Cascalheira
Summary: Current research on resveratrol treatment for gliomas suggests that resveratrol can slow down tumor growth in animal glioma models. Combination therapy with temozolomide is more effective than temozolomide alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Multidisciplinary
Nan Zhang, Jianfei Nao, Xiaoyu Dong
Summary: This meta-analysis investigates the possible mechanisms of salidroside in treating Alzheimer's disease. The results show that salidroside improves behavioral abnormalities in animal models and has antioxidant, anti-inflammatory, and neuroprotective effects. However, further studies are needed to confirm its therapeutic potential.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Clinical Neurology
Adilson Marques, Andreas Ihle, Alcir Souza, Miguel Peralta, Margarida Gaspar de Matos
Summary: Religious-based interventions have shown positive effects in reducing depressive symptoms among various populations, such as patients with chronic illnesses, pregnant women, and elderly nursing home residents.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Plant Sciences
Jing-Fang Luo, Yu Dong, Jia-Yue Chen, Jia-Hong Lu
Summary: Rectal squamous cell carcinoma is quite common and dangerous once it occurs. Patients with rectal squamous cell carcinoma often put a financial burden on their families and society, and may face challenges in receiving treatment and continuing work. This increase in cases also adds pressure on medical resources in society.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Fanjing Kong, Tianyu Wu, Jingyi Dai, Zhenwei Zhai, Jie Cai, Zhishan Zhu, Ying Xu, Tao Sun
Summary: This systematic review and meta-analysis evaluated the effects and potential mechanisms of GLP-1 RAs in AD animal models. The results showed that GLP-1 RAs could improve learning and memory abilities, and reduce Aβ deposition and phosphorylated tau levels in the brains of AD rodents.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Yi-Bo He, Yong-Lin Liu, Zheng-Dong Yang, Jia-Hong Lu, Yao Song, Yan-Ming Guan, Yi-Min Chen
Summary: The study findings indicated that G-Rg1 has positive effects in improving dopaminergic neurons and Nissl-positive cells in PD models, as well as reducing pole test time and increasing dopamine levels in the striatum.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Engineering, Biomedical
Jinwei Yang, Yuhao Kang, Wanlu Zhao, Jia Jiang, Yanbiao Jiang, Bing Zhao, Mingyue Jiao, Bo Yuan, Jinzhong Zhao, Bin Ma
Summary: This study evaluated the outcomes of various materials for rotator cuff repair in animal models and found that naturally derived biomaterials showed better biomechanical properties in the rabbit model.
BIOACTIVE MATERIALS
(2022)
Review
Nutrition & Dietetics
Tommaso Filippini, Susan Fairweather-Tait, Marco Vinceti
Summary: This systematic review and meta-analysis on the effects of selenium supplementation on immune function in healthy people concludes that the overall impact is inconsistent and heterogeneous. The evidence does not support the need to supplement selenium beyond the recommended dietary intake for beneficial effects on immune function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Medicine, Research & Experimental
Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan-Mueller, Christian Bonde Pedersen, Tiit Mathiesen, Christian Mawrin, Martin Wirenfeldt, Bjarne Winther Kristensen, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen
Summary: This systematic review found high consistent tumor take rates (TTRs) in established cell line models and varying TTRs in primary patient-derived models and genetically engineered models. However, there were several issues identified regarding the quality of reporting and methodological approach, which reduced the validity, transparency, and reproducibility of the studies and suggested a high risk of publication bias. Finally, each tumor model type has specific roles in research based on their advantages (and disadvantages).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Jing Li, Haiyan Zhang, Zhu Dai
Summary: The systematic review and meta-analysis indicated that ketogenic diet supplementation significantly prolonged survival time, reduced tumor weight and volume, and showed remarkable effects in animals with limited tumor types.
FRONTIERS IN NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Shuangyuan Hu, Pengfei Wei, Wei Li, Qingsong Liu, Shuanglan Chen, Caiyu Hu, Xiaochuan Guo, Xiao Ma, Jinhao Zeng, Yi Zhang
Summary: Berberine (BBR) has therapeutic effects in ulcerative colitis (UC) by reducing disease activity, preventing colon damage and weight loss. It modulates multiple mechanisms including inflammation, oxidative stress, and barrier function.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Engineering, Biomedical
Jiazhen Zhang, Yanbiao Jiang, Zhizhong Shang, Bing Zhao, Mingyue Jiao, Wenbo Liu, Maobo Cheng, Bao Zhai, Yajuan Guo, Bin Liu, Xinli Shi, Bin Ma
Summary: The study reviewed animal studies on biodegradable metals for bone defect repair and found mixed effects on repair and degradation compared to traditional biomaterials. However, there were limitations in experimental design and overall evidence quality, highlighting the need for further evidence-based research for clinical translation.
BIOACTIVE MATERIALS
(2021)
Review
Anesthesiology
Monique van Velzen, Jack D. C. Dahan, Eveline L. A. van Dorp, Jeffrey S. Mogil, Carlijn R. Hooijmans, Albert Dahan
Summary: Ketamine shows significant antiallodynic effects in mouse and rat models of nerve injury, with chronic administration resulting in lasting relief of allodynia. However, a single administration does not provide sustained relief, indicating a need for further research into the long-term efficacy of ketamine treatment in neuropathic pain.
Review
Health Care Sciences & Services
Kas Woudstra, Rob Reuzel, Maroeska Rovers, Marcia Tummers
Summary: This study provides an overview of participatory approaches in the development of medical devices, categorizing them into collaboration, involvement, and consultation levels. Patients and healthcare professionals are commonly engaged, with workshops and interviews being the most frequently used methods. Challenges include issues related to sampling, analysis, social dynamics, feasibility, and topic scope.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Obstetrics & Gynecology
Malou E. Gelderblom, Veerle Jaspers, Reinier P. Akkermans, Brigitte Slangen, Angele L. M. Oei, Alexandra A. van Ginkel, Huy Ngo, Joanna IntHout, Rosella P. M. G. Hermens, Joanne A. de Hullu, Jurgen M. J. Piek
Summary: This study aimed to determine the implementation of counseling and performance of opportunistic salpingectomy (OS) between 2015 and 2018, and its patient, surgical, physician, and hospital characteristics. The results showed that the proportion of counseling and performance increased over the years, but there were still variations. Therefore, an implementation strategy tailored to associated determinants is recommended.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, General & Internal
Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P. Daskalopoulos, Maddalena Fratelli, Bjoern Gerlach, Peter M. A. Groenen, Sabine M. Holter, Julia M. L. Menon, Ali Mobasheri, Nikki Osborne, Merel Ritskes-Hoitinga, Bettina Ryll, Elmar Schmitt, Anton Ussi, Antonio L. Andreu, Emmet McCormack
Summary: Personalized medicine aims to provide tailor-made prevention and treatment strategies for specific groups, but there are challenges in clinical relevance and model validity. Researchers have developed a set of recommendations to improve the robustness of preclinical methods in translational research for personalized medicine through literature review, expert discussions, and consensus meetings.
Review
Obstetrics & Gynecology
Majke H. D. van Bommel, Joanna IntHout, Guus Veldmate, C. Marleen Kets, Joanne A. de Hullu, Anne M. van Altena, Marline G. Harmsen
Summary: The use of oral contraceptive pills may increase the risk of breast cancer but decrease the risk of ovarian cancer in BRCA1/2-PV carriers. Tubal ligation also offers protection against ovarian cancer. Counselling for BRCA1/2-PV carriers should be personalized, taking into account genetic and non-genetic factors as well as patient preferences.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Kirsten B. Kluivers, Metteke Kamping, Alfredo L. Milani, Joanna IntHout, Mariella I. Withagen
Summary: This study is an extended follow-up study after 12 years, focusing on the subjective outcomes of women who underwent surgery for recurrent pelvic organ prolapse. The results showed no difference in subjective outcomes between the groups, but there was a statistically significant higher number of women who required further operations in the mesh group.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Review
Obstetrics & Gynecology
Cecile C. Hulshoff, Aniek Hofstede, Joanna Inthout, Ralph R. Scholten, Marc E. A. Spaanderman, Hanna Wollaars, Joris van Drongelen
Summary: This systematic review and meta-analysis compared the outcomes of laparoscopic and open laparotomy abdominal cerclage approaches in women with cervical insufficiency. The results showed that both methods had similar survival rates and gestational age at delivery. However, there were some differences in perioperative care, surgical complications, and complications during pregnancy.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Neurosciences
Elise J. Heesbeen, Elisabeth Y. Bijlsma, P. Monika Verdouw, Caspar van Lissa, Carlijn Hooijmans, Lucianne Groenink
Summary: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat anxiety disorders, but their effects on fear learning are not well understood.
PSYCHOPHARMACOLOGY
(2023)
Review
Cell & Tissue Engineering
Melissa J. J. van Velthoven, Aksel N. Gudde, Frederique Struijs, Egbert Oosterwijk, Jan-Paul Roovers, Zeliha Guler, Carlijn R. Hooijmans, Paul H. J. Kouwer
Summary: Growth factors, especially basic fibroblast growth factor, promote vaginal wound healing in vitro, but the effects are less prominent in vivo. More research is needed to improve surgical outcomes for pelvic organ prolapse, including improved preclinical models.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Medicine, Research & Experimental
Niels van Beuningen, Sinne Alkema, Nils Hijlkema, Brun Ulfhake, Rafael Frias, Merel Ritskes-Hoitinga, Wynand Alkema
Summary: This paper introduces a fast algorithm called 3Ranker for finding non-animal alternative methods in biomedical research. By utilizing machine learning and expert-curated data, the algorithm is able to accurately identify potential alternatives to animal use in a large number of articles. The algorithm performs well with Area Under the Curve (AUC) values ranging from 0.85-0.95 and demonstrates differences in the early implementation of the Three Rs principles across different research domains.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
(2023)
Article
Infectious Diseases
Denis R. Katundu, Desderius Chussi, Christa E. van der Gaast-de Jongh, Maroeska M. Rovers, Marien I. de Jonge, Gerjon Hannink, Niels van Heerbeek
Summary: Despite the lack of effectiveness, prophylactic antibiotics are still frequently used in children after tonsillectomy. This study investigated the effect of prophylactic amoxicillin and found no significant difference compared to placebo in terms of tonsillitis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Sebastian Franik, Kathrin Fleischer, Barbara Kortmann, Nike M. Stikkelbroeck, Kathleen D'Hauwers, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Solange Grunenwald, Tim van de Grift, Audrey Cartault, Annette Richter-Unruh, Nicole Reisch, Ute Thyen, Joanna IntHout, Hedi L. Claahsen-van der Grinten, Dsd LIFE Grp
Summary: The study investigated the quality of life (QOL) in men with Klinefelter syndrome (KS) and found lower scores in the physical, psychological, and social domains compared to a healthy reference population. Discrimination, reduced social activities, and chronic health problems were associated with decreased QOL.
ENDOCRINE CONNECTIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Birgitte S. Kousholt, Kirstine F. Praestegaard, Jennifer C. Stone, Anders F. Thomsen, Thea T. Johansen, Merel Ritskes-Hoitinga, Gregers Wegener, Johnny Roughan, Laura Calvillo
Summary: Currently, there is insufficient reporting of 3Rs approaches in preclinical publications to guide researchers. Other strategies such as education, interdisciplinary collaboration, and 3Rs funding initiatives are needed.
Article
Clinical Neurology
Ilaria Viozzi, Maroeska M. Rovers, Christiaan G. Overduin, Mark ter Laan
Summary: Introduction: The application of stereotactic laser ablation (SLA) for intra-cranial tumours has been growing, but comparative trials are lacking. This study investigated the familiarity with SLA and opinion on potential indications of European neurosurgeons. Results showed that most respondents considered SLA as a treatment option for recurrent glioblastoma, recurrent metastases, and newly diagnosed deep-seated glioblastoma.
Article
Oncology
Ilaria Viozzi, Christiaan G. Overduin, Anne Rijpma, Maroeska M. Rovers, Mark ter Laan
Summary: This study aimed to investigate the effectiveness of laser interstitial thermal therapy (LITT) in the treatment of newly diagnosed glioblastoma (nGBM) that cannot be surgically removed. The findings suggest that conducting a randomized controlled trial (RCT) on LITT in patients with irresectable nGBM is feasible, and initial safety data is acceptable.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Engineering, Biomedical
Thomas R. F. van Steenbergen, Han Nijsink, Thomas G. E. Eggen, Dennis Janssen, Maroeska M. Rovers, Ingrid C. M. van der Geest, J. J. Futterer
Summary: In this exploratory study on 20 cadaveric bone tumor models, navigated curettage was not found to be more accurate than freehand curettage. However, the presence of remaining tumor indicates that there is still room for improvement in curettage procedures. The novice user was less accurate with navigation compared to freehand, which could be attributed to the learning curve. Furthermore, the expert user employed a different surgical approach, focusing more on complete tumor removal rather than preserving the surrounding bone.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
