4.6 Article

Refining animal research: The Animal Study Registry

Journal

PLOS BIOLOGY
Volume 17, Issue 10, Pages -

Publisher

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3000463

Keywords

-

Funding

  1. German Federal Institute for Risk Assessment (BfR)

Ask authors/readers for more resources

The Animal Study Registry (ASR; www.animalstudyregistry.org) was launched in January 2019 for preregistration of animal studies in order to increase transparency and reproducibility of bioscience research and to promote animal welfare. The registry is free of charge and is designed for exploratory and confirmatory studies within applied science as well as basic and preclinical research. The registration form helps scientists plan their study thoroughly by asking detailed questions concerning study design, methods, and statistics. With registration, the study automatically receives a digital object identifier (DOI) that marks it as intellectual property of the researcher. To accommodate the researchers concerns about theft of ideas, users can restrict the visibility of their registered studies for up to 5 years. The full content of the study becomes publicly accessible at the end of the embargo period. Because the platform is embedded in the infrastructure of the German Federal Government, continuity and data security are provided. By registering a study in the ASR, researchers can show their commitment to transparency and data quality to reviewers and editors, to third-party donors, and to the general public.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Reproductive Biology

25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth

Philip Marx-Stoelting, Marize de L. M. Solano, Hiroaki Aoyama, Ralf H. Adams, Anna Bal-Price, Jochen Buschmann, Ibrahim Chahoud, Ruth Clark, Tian Fang, Michio Fujiwara, Michael Gelinsky, Konstanze Grote, Masao Horimoto, Susanne Hougaard Bennekou, Rupert Kellner, Makiko Kuwagata, Marcel Leist, Annemarie Lang, Weihua Li, Alberto Mantovani, Susan L. Makris, Francisco Paumgartten, Monique Perron, Magdalini Sachana, Anne Schmitt, Steffen Schneider, Gilbert Schoenfelder, Frank Schulze, Kohei Shiota, Roland Solecki

Summary: The 10th Berlin Workshop aimed to discuss scientific, methodologic and regulatory aspects in risk assessment of developmental toxicity and to debate alternative strategies in testing developmental effects in the future. Recommendations for improvement of categorization, database update, and development of adverse outcome pathways related to DNT were discussed. Collaboration with the medical community was suggested to enhance relevance of test results to humans and accelerate the development of new technologies for identifying developmental health risks.

REPRODUCTIVE TOXICOLOGY (2021)

Article Environmental Sciences

The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells

Marja Kornhuber, Sebastian Dunst, Gilbert Schoenfelder, Michael Oelgeschlaeger

Summary: This study introduces a novel high-throughput screening-compatible assay, E-Morph Assay, that accurately predicts the estrogenic potential of environmental chemicals by quantifying changes in the cell contact morphology of human breast cancer cells. The assay classifies substances into four main categories of estrogenic activity based on a classification model developed using reference substances.

ENVIRONMENT INTERNATIONAL (2021)

Review Neurosciences

Current Methods to Investigate Nociception and Pain in Zebrafish

Nils Ohnesorge, Celine Heinl, Lars Lewejohann

Summary: Pain is a challenging negative emotion to manage, and recent research has shown the potential for studying nociception and pain in fish models. The zebrafish, already well-established in various research areas, presents a powerful tool for pain research with the combination of different methodologies. Observing complex behavior and neuronal activity in zebrafish larvae offers new opportunities for studying pain.

FRONTIERS IN NEUROSCIENCE (2021)

Editorial Material Biochemistry & Molecular Biology

How many animals are used for SARS-CoV-2 research?

Philipp Schwedhelm, Johanna Kusnick, Celine Heinl, Gilbert Schonfelder, Bettina Bert

EMBO REPORTS (2021)

Article Environmental Sciences

Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions

Saskia Klutzny, Marja Kornhuber, Andrea Morger, Gilbert Schoenfelder, Andrea Volkamer, Michael Oelgeschlaeger, Sebastian Dunst

Summary: This study successfully identified substances with potential estrogenic activities through the further development and application of the E-Morph assay, and evaluated and analyzed the results using computational methods and models. The combination of in vitro HTS approaches with in silico methods proved to be effective in prioritizing substances for subsequent testing against higher tier human endpoints.

ENVIRONMENT INTERNATIONAL (2022)

Review Developmental Biology

In vitro models of human development and their potential application in developmental toxicity testing

Mirjam Niethammer, Tanja Burgdorf, Elisa Wistorf, Gilbert Schoenfelder, Mandy Kleinsorge

Summary: This article discusses the application of in vitro models in developmental toxicity testing, questioning the relevance of adverse reactions in animals to humans. It also points out that the currently developed cell culture-based models of embryo-fetal development lack sufficient levels of standardization and reproducibility.

DEVELOPMENT (2022)

Review Biochemistry & Molecular Biology

A guide to open science practices for animal research

Kai Diederich, Kathrin Schmitt, Philipp Schwedhelm, Bettina Bert, Celine Heinl

Summary: This article highlights the importance of open science practices in translational biomedical research and provides practical methods that can be implemented throughout the research process. These methods contribute to improving the transparency and quality of research, as well as increasing the audience and scientific reach of published work.

PLOS BIOLOGY (2022)

Review Veterinary Sciences

Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice

Paul Mieske, Ute Hobbiesiefken, Carola Fischer-Tenhagen, Celine Heinl, Katharina Hohlbaum, Pia Kahnau, Jennifer Meier, Jenny Wilzopolski, Daniel Butzke, Juliane Rudeck, Lars Lewejohann, Kai Diederich

Summary: Boredom refers to an emotional state where an individual has nothing to do, is not interested in the surrounding, and feels dreary and monotony. This state can have detrimental effects on the mental and physical health of laboratory animals. Providing enrichment in the environment has been recognized as a crucial solution to improve their welfare.

FRONTIERS IN VETERINARY SCIENCE (2022)

Article Mathematical & Computational Biology

Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments

Mariana Neves, Antonina Klippert, Fanny Knoespel, Juliane Rudeck, Ailine Stolz, Zsofia Ban, Markus Becker, Kai Diederich, Barbara Grune, Pia Kahnau, Nils Ohnesorge, Johannes Pucher, Gilbert Schoenfelder, Bettina Bert, Daniel Butzke

Summary: Current animal protection laws require replacement of animal experiments with alternative methods, which can be time-consuming and require careful screening of biomedical publications. In this study, the GoldHamster corpus was developed and annotated to identify experimental models. Machine learning experiments using the corpus demonstrated high agreement and reliable predictive models for classifying biomedical literature. The corpus and classifier will support the retrieval of alternative methods to animal experiments.

JOURNAL OF BIOMEDICAL SEMANTICS (2023)

Article Biochemical Research Methods

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading

Julia Scheinpflug, Chris Tina Hoefer, Sarah S. S. Schmerbeck, Matthias Steinfath, Jennifer Doka, Yonatan Afework Tesfahunegn, Norman Violet, Kostja Renko, Konrad Gulich, Thilo John, Marlon R. R. Schneider, Elisa Wistorf, Gilbert Schoenfelder, Frank Schulze

Summary: Continuous remodelling of human bone depends on physicochemical parameters and mechanical load. A microphysiological system (MPS) was developed for precise control of these parameters and investigation of bone formation. Primary human osteoblasts were cultured in the MPS, allowing monitoring of cell viability, metabolism, and extracellular matrix mineralization. The MPS provides valuable insights into bone biology and (patho-)physiological processes.

LAB ON A CHIP (2023)

Article Multidisciplinary Sciences

Declaration of common standards for the preregistration of animal research-speeding up the scientific progress

Celine Heinl, Anna M. D. Scholman-Vegh, David Mellor, Gilbert Schoenfelder, Daniel Strech, Steven Chamuleau, Bettina Bert

Summary: Preregistration is an effective tool in clinical research to improve research quality and reporting. In preclinical research, preregistration can facilitate the translation of research results into clinical breakthroughs. However, the implementation of preregistration in animal research is slow. Despite this, research institutions, funders, and publishers are recognizing the value of preregistration and paving the way for its broader acceptance in the future.

PNAS NEXUS (2022)

Article Food Science & Technology

A prospective whole-mixture approach to assess risk of the food and chemical exposome

T. Tralau, M. Oelgeschlager, J. Kugler, D. Bloch, A. Braeuning, T. Burgdorf, P. Marx-Stoelting, V Ritz, S. Schmeisser, A. Trubiroha, S. Zellmer, A. Luch, G. Schoenfelder, R. Solecki, A. Hensel

Summary: Current legislation mainly focuses on the toxicological evaluation of single substances, lacking measures for the regulation of chemical mixtures. Researchers propose a proactive approach using the exposome concept and large-scale hazard screens to identify chemicals in mixtures and predict potential health risks. They suggest generating co-exposure patterns for specific consumer groups to assess the risk of identified mixtures, especially those from food, medicine, and cleaning products.

NATURE FOOD (2021)

No Data Available