Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes

(2017) Najah Abi-Gerges et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

(2017) Oliver J. Britton et al.   Frontiers in Physiology

Computational Tool for Fast in silico Evaluation of hERG K+ Channel Affinity

(2017) Giulia Chemi et al.   Frontiers in Chemistry

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

(2016) M Cummins Lancaster et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias

(2016) Hong-Gang Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

(2016) Sara Dutta et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept

(2016) Mitra Abbasi et al.   TOXICOLOGY MECHANISMS AND METHODS

Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept

(2016) Mitra Abbasi et al.   TOXICOLOGY MECHANISMS AND METHODS

Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes

(2016) Haoyu Zeng et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model

(2016) Hua Rong Lu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance

(2015) Hugo M Vargas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

(2015) Blanca Rodriguez et al.   EUROPACE

The genetics underlying acquired long QT syndrome: impact for genetic screening

(2015) Hideki Itoh et al.   EUROPEAN HEART JOURNAL

Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells

(2015) Jong J. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pred-hERG: A Novel web-Accessible Computational Tool for Predicting Cardiac Toxicity

(2015) Rodolpho C. Braga et al.   Molecular Informatics

High Throughput Measurement of Ca++Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds

(2015) Hua Rong Lu et al.   TOXICOLOGICAL SCIENCES

Representing Variability and Transmural Differences in a Model of Human Heart Failure

(2015) Mohamed M. Elshrif et al.   IEEE Journal of Biomedical and Health Informatics

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

(2014) Christopher E. Dempsey et al.   Journal of Chemical Information and Modeling

Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

(2014) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electrophysiological and Structural Remodeling in Heart Failure Modulate Arrhythmogenesis. 1D Simulation Study

(2014) Juan F. Gomez et al.   PLoS One

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

(2014) Gary R. Mirams et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia

(2014) C. Ian Spencer et al.   Stem Cell Reports

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Electrophysiological changes in heart failure and their implications for arrhythmogenesis

(2013) R. Coronel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Ecologists should not use statistical significance tests to interpret simulation model results

(2013) J. Wilson White et al.   OIKOS

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

(2013) John Walmsley et al.   PLoS One

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

(2013) Kylie A. Beattie et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Toward an Integrative Computational Model of the Guinea Pig Cardiac Myocyte

(2012) Laura Doyle Gauthier et al.   Frontiers in Physiology

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment

(2011) M. R. Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species

(2011) Thomas O'Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism of Reverse Rate-Dependent Action of Cardioactive Agents

(2011) T. Banyasz et al.   CURRENT MEDICINAL CHEMISTRY

Combined Receptor and Ligand-Based Approach to the Universal Pharmacophore Model Development for Studies of Drug Blockade to the hERG1 Pore Domain

(2011) Serdar Durdagi et al.   Journal of Chemical Information and Modeling

Virtual population generator for human cardiomyocytes parameters:in silicodrug cardiotoxicity assessment

(2011) Sebastian Polak et al.   TOXICOLOGY MECHANISMS AND METHODS

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

(2011) D.J. Leishman et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Integrated risk assessment and predictive value to humans of non-clinical repolarization assays

(2009) Robert M Wallis   BRITISH JOURNAL OF PHARMACOLOGY

Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development

(2009) Vaibhav Salvi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

A framework to assess the translation of safety pharmacology data to humans

(2009) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

In vitromodels of proarrhythmia

(2008) C L Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sensitive and reliable proarrhythmiain vivoanimal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

(2008) A Sugiyama   BRITISH JOURNAL OF PHARMACOLOGY

Chaste: using agile programming techniques to develop computational biology software

(2008) J. Pitt-Francis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES