p53 signaling in cancer progression and therapy

FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma

(2021) Lin Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells

(2021) Luisa Klemke et al.   Frontiers in Oncology

Editorial: Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments

(2021) Oleg Timofeev   Frontiers in Oncology

Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway

(2020) Scott Bang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

(2020) Arjelle Decasa Agupitan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

(2020) Nicola Alessio et al.   eLife

Role of p53 in the Regulation of Cellular Senescence

(2020) Mahmut Mijit et al.   Biomolecules

Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms

(2020) Jessica Beck et al.   CARCINOGENESIS

Targeting p53 for the treatment of cancer

(2020) Michael J. Duffy et al.   SEMINARS IN CANCER BIOLOGY

p53 Affects PGC1α Stability Through AKT/GSK-3β to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer

(2020) Xinyue Deng et al.   Frontiers in Oncology

Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

(2020) Moshe Lapidot et al.   Cancers

SETD3 is a positive regulator of DNA-damage-induced apoptosis

(2019) Elina Abaev-Schneiderman et al.   Cell Death & Disease

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Suppressor p53-Mediated Structural Reorganization of the Transcriptional Coactivator p300

(2019) Raka Ghosh et al.   BIOCHEMISTRY

Inflammatory signaling in genomically instable cancers

(2019) Francien Talens et al.   CELL CYCLE

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

TP53 Mutations Promote Immunogenic Activity in Breast Cancer

(2019) Zhixian Liu et al.   Journal of Oncology

Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

(2019) Tianyi Liu et al.   Frontiers in Cell and Developmental Biology

Multiple functions of DYRK2 in cancer and tissue development

(2019) Saishu Yoshida et al.   FEBS LETTERS

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

(2019) Alexander Thiem et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road

(2019) Magdalena C. Liebl et al.   BIOESSAYS

The role of acetylation sites in the regulation of p53 activity

(2019) Yun Wang et al.   MOLECULAR BIOLOGY REPORTS

Mutant p53 in breast cancer: potential as a therapeutic target and biomarker

(2018) Michael J. Duffy et al.   BREAST CANCER RESEARCH AND TREATMENT

p53 as the focus of gene therapy: past, present and future

(2018) Joana FA Valente et al.   CURRENT DRUG TARGETS

The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic

(2018) Wei-Wei Zhang et al.   HUMAN GENE THERAPY

Protein arginine methylation: an emerging regulator of the cell cycle

(2018) Anita E. Raposo et al.   Cell Division

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

(2018) Ramona Schulz-Heddergott et al.   CANCER CELL

Awakening the “guardian of genome”: reactivation of mutant p53

(2018) Akshay Binayke et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

(2018) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 as a target for cancer treatment

(2017) Michael J. Duffy et al.   EUROPEAN JOURNAL OF CANCER

Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer

(2017) D Ashikari et al.   ONCOGENE

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence

(2017) Nicola Alessio et al.   NEOPLASIA

Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer

(2017) Erika S. Dahl et al.   Frontiers in Oncology

Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events

(2016) Kyung-Sun Heo et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

(2016) Yan Cui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

The regulation of radiosensitivity by p53 and its acetylation

(2015) Jing Zhang et al.   CANCER LETTERS

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways

(2015) Maria Shatz et al.   Oncotarget

MiR expression profiles of paired primary colorectal cancer and metastases by next-generation sequencing

(2015) M Neerincx et al.   Oncogenesis

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages

(2014) Julie M. Lowe et al.   CANCER RESEARCH

Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53

(2014) David Quigley et al.   MOLECULAR CANCER RESEARCH

Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes

(2014) Che-Pei Kung et al.   MOLECULAR CANCER RESEARCH

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

(2014) Jayne Loughery et al.   NUCLEIC ACIDS RESEARCH

Toll-Like Receptor 4 Prompts Human Breast Cancer Cells Invasiveness via Lipopolysaccharide Stimulation and Is Overexpressed in Patients with Lymph Node Metastasis

(2014) Huan Yang et al.   PLoS One

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

(2014) Matthias Drosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

The Yin and Yang of Toll-like receptors in cancer

(2013) J-P Pradere et al.   ONCOGENE

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

(2013) Shalom Madar et al.   PLoS One

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

(2013) Fabricio Loayza-Puch et al.   GENOME BIOLOGY

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy

(2012) Samisubbu R. Naidu et al.   CELL CYCLE

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

The substitutions G245C and G245D in the Zn2+-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain

(2012) S.S. Pintus et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration

(2012) Elena Rainero et al.   JOURNAL OF CELL BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

(2012) Maria V. Chiantore et al.   PLoS One

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Multiple Stress Signals Activate Mutant p53 In Vivo

(2011) Y.-A. Suh et al.   CANCER RESEARCH

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53

(2011) Sébastien Gillotin et al.   FEBS LETTERS

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73

(2011) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

(2011) J E Noll et al.   ONCOGENE

Curaxins: Anticancer Compounds That Simultaneously Suppress NF- B and Activate p53 by Targeting FACT

(2011) A. V. Gasparian et al.   Science Translational Medicine

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer

(2010) E L Wang et al.   BRITISH JOURNAL OF CANCER

TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis

(2010) Manabu Taura et al.   CANCER SCIENCE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death

(2010) Elizabeth Garner et al.   CELL CYCLE

The missing Zinc: p53 misfolding and cancer

(2010) Stewart N. Loh   Metallomics

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

(2009) J. Boros et al.   GENOME RESEARCH

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

(2008) A. Restle et al.   NUCLEIC ACIDS RESEARCH